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The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Preservation of Memory With Conformal Avoidance of the Hippocampal Neural Stem-Cell Compartment During Whole-Brain Radiotherapy for Brain Metastases (RTOG 0933): A Phase II Multi-Institutional Trial

Open access
Gondi, Vinai, Pugh, Stephanie L., Tome, Wolfgang A., Caine, Chip, Corn, Ben, Kanner, Andrew, Rowley, Howard, Kundapur, Vijayananda, DeNittis, Albert, Greenspoon, Jeffrey N., Konski, Andre A., Bauman, Glenn S., Shah, Sunjay, Shi, Wenyin, Wendland, Merideth, Kachnic, Lisa, Mehta, Minesh P.·2014·Journal of Clinical Oncology
DOI 10.1200/jco.2014.57.2909
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Abstract

Purpose: Hippocampal neural stem-cell injury during whole-brain radiotherapy (WBRT) may play a role in memory decline. Intensity-modulated radiotherapy can be used to avoid conformally the hippocampal neural stem-cell compartment during WBRT (HA-WBRT). RTOG 0933 was a single-arm phase II study of HA-WBRT for brain metastases with prespecified comparison with a historical control of patients treated with WBRT without hippocampal avoidance. Patients and Methods: Eligible adult patients with brain metastases received HA-WBRT to 30 Gy in 10 fractions. Standardized cognitive function and quality-of-life (QOL) assessments were performed at baseline and 2, 4, and 6 months. The primary end point was the Hopkins Verbal Learning Test–Revised Delayed Recall (HVLT-R DR) at 4 months. The historical control demonstrated a 30% mean relative decline in HVLT-R DR from baseline to 4 months. To detect a mean relative decline ≤ 15% in HVLT-R DR after HA-WBRT, 51 analyzable patients were required to ensure 80% statistical power with α = 0.05. Results: Of 113 patients accrued from March 2011 through November 2012, 42 patients were analyzable at 4 months. Mean relative decline in HVLT-R DR from baseline to 4 months was 7.0% (95% CI, −4.7% to 18.7%), significantly lower in comparison with the historical control (P < .001). No decline in QOL scores was observed. Two grade 3 toxicities and no grade 4 to 5 toxicities were reported. Median survival was 6.8 months. Conclusion: Conformal avoidance of the hippocampus during WBRT is associated with preservation of memory and QOL as compared with historical series.

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Metadata

Authors
Gondi, V., Pugh, S. L., Tome, W. A., Caine, C., Corn, B., Kanner, A., Rowley, H., Kundapur, V., DeNittis, A., Greenspoon, J. N., Konski, A. A., Bauman, G. S., Shah, S., Shi, W., Wendland, M., Kachnic, L., & Mehta, M. P.
Venue
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Published
2014-12-01
Volume
32
Issue
34
Pages
3810-3816
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
DOI
10.1200/jco.2014.57.2909
OpenAlex
W2141604895
Cited by
1,148
References
22
FWCI
64.70
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Preservation of Memory With Conformal Avoidance of the Hippocampal Neural Stem-Cell Compartment During Whole-Brain Radiotherapy for Brain Metastases (RTOG 0933): A Phase II Multi-Institutional Trial. https://app.cochat.ai/papers/10.1200/jco.2014.57.2909
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Gondi, V., Pugh, S. L., Tome, W. A., Caine, C., Corn, B., Kanner, A., Rowley, H., Kundapur, V., DeNittis, A., Greenspoon, J. N., Konski, A. A., Bauman, G. S., Shah, S., Shi, W., Wendland, M., Kachnic, L., & Mehta, M. P. (2014). Preservation of Memory With Conformal Avoidance of the Hippocampal Neural Stem-Cell Compartment During Whole-Brain Radiotherapy for Brain Metastases (RTOG 0933): A Phase II Multi-Institutional Trial. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2014.57.2909

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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