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Management of Nasopharyngeal Carcinoma: Current Practice and Future Perspective
Abstract
Nasopharyngeal carcinoma of the undifferentiated subtype is endemic to southern China, and patient prognosis has improved significantly over the past three decades because of advances in disease management, diagnostic imaging, radiotherapy technology, and broader application of systemic therapy. Despite the excellent local control with modern radiotherapy, distant failure remains a key challenge. Advances in molecular technology have helped to decipher the molecular pathogenesis of nasopharyngeal carcinoma as well as its etiologic association with the Epstein-Barr virus. This in turn has led to the discovery of novel biomarkers and drug targets, rendering this cancer site a current focus for new drug development. This article reviews and appraises the key literature on the current management of nasopharyngeal carcinoma and future directions in clinical research.
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Citations
Cited by
Chen, Y.-P., Chan, A. T. C., Le, Q.-T., Blanchard, P., Sun, Y., & Ma, J. (2019) · The Lancet · doi:10.1016/s0140-6736(19)30956-0 · Cited by 3,077
Self-citationZhang, L., Huang, Y., Hong, S., Yang, Y., Yu, G., Jia, J., Peng, P., Wu, X., Lin, Q., Xi, X., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31388-5 · Cited by 522
Fang, W., Yang, Y., Ma, Y., Hong, S., Lin, L., He, X., Xiong, J., Li, P., Zhao, H., Huang, Y., et al. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30495-9 · Cited by 489
Management of locally recurrent nasopharyngeal carcinoma
Lee, A. W. M., Ng, W. T., Chan, J. Y. W., Corry, J., Mäkitie, A., Mendenhall, W. M., Rinaldo, A., Rodrigo, J. P., Saba, N. F., Strojan, P., et al. (2019) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2019.101890 · Cited by 371
Self-citationApplication of Artificial Intelligence for Nasopharyngeal Carcinoma Management – A Systematic Review
Ng, W. T., But, B., Choi, H. C., de Bree, R., Lee, A. W., Lee, V. H., López, F., Mäkitie, A. A., Rodrigo, J. P., Saba, N. F., et al. (2022) · Cancer Management and Research · doi:10.2147/cmar.s341583 · Cited by 33
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Metadata
- Authors
- Lee, A. W. M., Ma, B. B. Y., Ng, W. T., & Chan, A. T. C.
- Venue
- Journal of Clinical Oncology
- Published
- 2015-10-10
- Volume
- 33
- Issue
- 29
- Pages
- 3356-3364
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2150434794
- Cited by
- 796
- References
- 0
- FWCI
- 40.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, A. W. M., Ma, B. B. Y., Ng, W. T., & Chan, A. T. C. (2015). Management of Nasopharyngeal Carcinoma: Current Practice and Future Perspective. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2015.60.9347
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