The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Management of locally recurrent nasopharyngeal carcinoma
Open accessAbstract
As a consequence of the current excellent loco-regional control rates attained using the generally accepted treatment paradigms involving intensity-modulated radiotherapy for nasopharyngeal carcinoma (NPC), only 10-20% of patients will suffer from local and/or nodal recurrence after primary treatment. Early detection of recurrence is important as localized recurrent disease is still potentially salvageable, but this treatment often incurs a high risk of major toxicities. Due to the possibility of radio-resistance of tumors which persist or recur despite adequate prior irradiation and the limited tolerance of adjacent normal tissues to sustain further additional treatment, the management of local failures remains one of the greatest challenges in this disease. Both surgical approaches for radical resection and specialized re-irradiation modalities have been explored. Unfortunately, available data are based on retrospective studies, and the majority of them are based on a small number of patients or relatively short follow-up. In this article, we will review the different salvage treatment options and associated prognostic factors for each of them. We will also propose a treatment algorithm based on the latest available evidence and discuss the future directions of treatment for locally recurrent NPC.
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Self-citationManagement of Nasopharyngeal Carcinoma: Current Practice and Future Perspective
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Self-citationFang, W., Yang, Y., Ma, Y., Hong, S., Lin, L., He, X., Xiong, J., Li, P., Zhao, H., Huang, Y., et al. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30495-9 · Cited by 489
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Bossi, P., Chan, A. T., Licitra, L., Trama, A., Orlandi, E., Hui, E. P., Halámková, J., Mattheis, S., Baujat, B., Hardillo, J., et al. (2021) · Annals of Oncology · doi:10.1016/j.annonc.2020.12.007 · Cited by 447
Jiang, L., Bin, Y., Huang, Y., Wu, L., Qiu, X., Du, Y., Mi, J., Liu, K., Deng, Y., Ning, J., et al. (2026) · Drug Resistance Updates · doi:10.1016/j.drup.2026.101374 · Cited by 1
Metadata
- Authors
- Lee, A. W. M., Ng, W. T., Chan, J. Y. W., Corry, J., Mäkitie, A., Mendenhall, W. M., Rinaldo, A., Rodrigo, J. P., Saba, N. F., Strojan, P., Suárez, C., Vermorken, J. B., Yom, S. S., & Ferlito, A.
- Venue
- Cancer Treatment Reviews
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 79
- Pages
- 101890
- ISSN
- 0305-7372 (ISSN-L)
- OpenAlex
- W2969932016
- Cited by
- 371
- References
- 30
- FWCI
- 26.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lee, A. W. M., Ng, W. T., Chan, J. Y. W., Corry, J., Mäkitie, A., Mendenhall, W. M., Rinaldo, A., Rodrigo, J. P., Saba, N. F., Strojan, P., Suárez, C., Vermorken, J. B., Yom, S. S., & Ferlito, A. (2019). Management of locally recurrent nasopharyngeal carcinoma. Cancer Treatment Reviews. https://doi.org/10.1016/j.ctrv.2019.101890
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