The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.
Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer
Open accessAbstract
Purpose: Sonic hedgehog (SHH), an activating ligand of smoothened (SMO), is overexpressed in > 70% of pancreatic cancers (PCs). We investigated the impact of vismodegib, an SHH antagonist, plus gemcitabine (GV) or gemcitabine plus placebo (GP) in a multicenter phase Ib/randomized phase II trial and preclinical PC models. Patients and Methods: Patients with PC not amenable to curative therapy who had received no prior therapy for metastatic disease and had Karnofsky performance score ≥ 80 were enrolled. Patients were randomly assigned in a one-to-one ratio to GV or GP. The primary end point was progression-free-survival (PFS). Exploratory correlative studies included serial SHH serum levels and contrast perfusion computed tomography imaging. To further investigate putative biologic mechanisms of SMO inhibition, two autochthonous pancreatic cancer models (Kras G12D; p16/p19 fl/fl; Pdx1-Cre and Kras G12D; p53 R270H/wt; Pdx1-Cre) were studied. Results: No safety issues were identified in the phase Ib portion (n = 7), and the phase II study enrolled 106 evaluable patients (n = 53 in each arm). Median PFS was 4.0 and 2.5 months for GV and GP arms, respectively (95% CI, 2.5 to 5.3 and 1.9 to 3.8, respectively; adjusted hazard ratio, 0.81; 95% CI, 0.54 to 1.21; P = .30). Median overall survival (OS) was 6.9 and 6.1 months for GV and GP arms, respectively (95% CI, 5.8 to 8.0 and 5.0 to 8.0, respectively; adjusted hazard ratio, 1.04; 95% CI, 0.69 to 1.58; P = .84). Response rates were not significantly different. There were no significant associations between correlative markers and overall response rate, PFS, or OS. Preclinical trials revealed no significant differences with vismodegib in drug delivery, tumor growth rate, or OS in either model. Conclusion: The addition of vismodegib to gemcitabine in an unselected cohort did not improve overall response rate, PFS, or OS in patients with metastatic PC. Our preclinical and clinical results revealed no statistically significant differences with respect to drug delivery or treatment efficacy using vismodegib.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Many of the recent promising clinical signals in PDAC have arisen through rigorous preclinical analyses in syngeneic and autochthonous models that predated the trial and informed its design288.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [288]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Siegel, R., Naishadham, D., & Jemal, A. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21166 · Cited by 11,825
FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer
Conroy, T., Desseigne, F., Ychou, M., Bouché, O., Guimbaud, R., Bécouarn, Y., Adenis, A., Raoul, J.-L., Gourgou-Bourgade, S., de la Fouchardière, C., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1011923 · Cited by 7,810
Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine
Von Hoff, D. D., Ervin, T., Arena, F. P., Chiorean, E. G., Infante, J., Moore, M., Seay, T., Tjulandin, S. A., Ma, W. W., Saleh, M. N., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1304369 · Cited by 6,712
Self-citationBurris, H. A., Moore, M. J., Andersen, J., Green, M. R., Rothenberg, M. L., Modiano, M., Cripps, M. C., Portenoy, R. K., Storniolo, A. M., Tarassoff, P. G., et al. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.6.2403 · Cited by 5,895
Moore, M. J., Goldstein, D., Hamm, J., Figer, A., Hecht, J. R., Gallinger, S., Au, H. J., Murawa, P., Walde, D., Wolff, R. A., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.9525 · Cited by 3,848
Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759
Olive, K. P., Jacobetz, M. A., Davidson, C. J., Gopinathan, A., McIntyre, D., Honess, D., Madhu, B., Goldgraben, M. A., Caldwell, M. E., Allard, D., et al. (2009) · Science · doi:10.1126/science.1171362 · Cited by 3,170
Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609
Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
Rhim, A. D., Oberstein, P. E., Thomas, D. H., Mirek, E. T., Palermo, C. F., Sastra, S. A., Dekleva, E. N., Saunders, T., Becerra, C. P., Tattersall, I. W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.021 · Cited by 2,085
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
Thayer, S. P., di Magliano, M. P., Heiser, P. W., Nielsen, C. M., Roberts, D. J., Lauwers, G. Y., Qi, Y., Gysin, S., Castillo, C. F. F.-D., Yajnik, V., et al. (2003) · Nature · doi:10.1038/nature02009 · Cited by 1,479
Flagged first, then by citations
1 of the 55 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Abe H, 2005, Radiat Med, 23, 364
- Jesus-Acosta A, 2014, J Clin Oncol, 32
Cited by
Sorted by citations
Items 201–300 of 560
SHH pathway inhibition is protumourigenic in adamantinomatous craniopharyngioma
Carreno, G., Boult, J. K. R., Apps, J. R., González-Meljem, J. M., Haston, S., Guiho, R., Stache, C., Danielson, L. S., Koers, A., Smith, L. M., et al. (2019) · Endocrine Related Cancer · doi:10.1530/erc-18-0538 · Cited by 40
Stroma-targeting strategies in pancreatic cancer: Past lessons, challenges and prospects
Polani, F., Grierson, P. M., & Lim, K. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i18.2105 · Cited by 42
Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer
Suchors, C., & Kim, J. (2022) · Cells · doi:10.3390/cells11162523 · Cited by 45
Latest Advances in the Use of Therapeutic Focused Ultrasound in the Treatment of Pancreatic Cancer
Mouratidis, P., & ter Haar, G. (2022) · Cancers · doi:10.3390/cancers14030638 · Cited by 40
Enhancing the Efficacy of CAR T Cells in the Tumor Microenvironment of Pancreatic Cancer
Henze, J., Tacke, F., Hardt, O., Alves, F., & Rawashdeh, W. A. (2020) · Cancers · doi:10.3390/cancers12061389 · Cited by 39
Hedgehog Signaling in Colorectal Cancer: All in the Stroma?
Geyer, N., & Gerling, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031025 · Cited by 40
Therapeutic advances in metastatic pancreatic cancer: a focus on targeted therapies
Turpin, A., Neuzillet, C., Colle, E., Dusetti, N., Nicolle, R., Cros, J. F., de Mestier, L., Bachet, J., & Hammel, P. R. (2022) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359221118019 · Cited by 41
Cancer-Associated Fibroblasts: Lessons from Pancreatic Cancer
Sherman, M. H., & di Magliano, M. P. (2023) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-061421-035400 · Cited by 39
Liang, C., Shi, S., Meng, Q., Liang, D., Ji, S., Zhang, B., Qin, Y., Xu, J., Ni, Q., & Yu, X. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2678-7 · Cited by 39
Fibroblast-derived prolargin is a tumor suppressor in hepatocellular carcinoma
Chiavarina, B., Ronca, R., Otaka, Y., Sutton, R. B., Rezzola, S., Yokobori, T., Chiodelli, P., Souche, F.-R., Pourquier, D., Maraver, A., et al. (2022) · Oncogene · doi:10.1038/s41388-021-02171-z · Cited by 39
Recent advances in targeted therapy for pancreatic adenocarcinoma
Fang, Y., Yang, W., Niu, Y., & Sun, Y. (2023) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v15.i4.571 · Cited by 40
Ellenrieder, V., König, A. O., & Seufferlein, T. T. W. (2016) · Digestion · doi:10.1159/000447739 · Cited by 38
Kumazoe, M., Takai, M., Hiroi, S., Takeuchi, C., Yamanouchi, M., Nojiri, T., Onda, H., Bae, J., Huang, Y., Takamatsu, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02162-9 · Cited by 38
Zhou, Q., Zhou, Y., Liu, X., & Shen, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-13869-0 · Cited by 38
Novel agents for pancreatic ductal adenocarcinoma: emerging therapeutics and future directions
Zhang, Y., Yang, C., Cheng, H., Fan, Z., Huang, Q., Yu, L., Fan, K., Luo, G., Jin, K., Wang, Z., et al. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0551-7 · Cited by 41
Metastatic pancreatic cancer: Mechanisms and detection (Review)
Chen, X., Liu, F., Xue, Q., Weng, X., & Xu, F. (2021) · Oncology Reports · doi:10.3892/or.2021.8182 · Cited by 38
Murphy, K. J., Chambers, C. R., Herrmann, D., Timpson, P., & Pereira, B. (2021) · Cancers · doi:10.3390/cancers13143481 · Cited by 37
Tanaka, H. Y., Nakazawa, T., Enomoto, A., Masamune, A., & Kano, M. R. (2023) · Cancers · doi:10.3390/cancers15030724 · Cited by 42
Yan, J., Wang, M., Lv, S., Chen, D., Wu, Z., Zhou, D., Zhang, S., Lv, J., Xu, K., Xu, C., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.01.055 · Cited by 37
Cao, J., Pickup, S., Clendenin, C. J., Blouw, B., Choi, H., Kang, D. W., Rosen, M. A., O'Dwyer, P. J., & Zhou, R. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-2276 · Cited by 37
Mellone, M., Piotrowska, K., Venturi, G., James, L., Bzura, A., Lopez, M. A., James, S., Wang, C., Ellis, M. J., Hanley, C. J., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-0435 · Cited by 36
EVI1 modulates oncogenic role of GPC1 in pancreatic carcinogenesis
Tanaka, M. H., Ishikawa, S., Ushiku, T., Morikawa, T., Isagawa, T., Yamagishi, M., Yamamoto, H., Katoh, H., Takeshita, K., Arita, J., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.20601 · Cited by 36
Abrams, S. L., Lertpiriyapong, K., Yang, L. V., Martelli, A. M., Cocco, L., Ratti, S., Falasca, M., Murata, R. M., Rosalen, P. L., Lombardi, P., et al. (2018) · Advances in Biological Regulation · doi:10.1016/j.jbior.2018.06.002 · Cited by 36
Nanomedicine for Imaging and Therapy of Pancreatic Adenocarcinoma
Brachi, G., Bussolino, F., Ciardelli, G., & Mattu, C. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00307 · Cited by 36
Targeting hedgehog signaling in pancreatic ductal adenocarcinoma
Quatannens, D., Verhoeven, Y., van Dam, P. A., Lardon, F., Prenen, H., Roeyen, G., Peeters, M., Smits, E., & Audenaerde, J. R. M. V. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108107 · Cited by 37
Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer
Scales, M. K., Velez-Delgado, A., Steele, N. G., Schrader, H. E., Stabnick, A. M., Yan, W., Mercado-Soto, N. M., Nwosu, Z., Johnson, C. N., Zhang, Y.-Q., et al. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010315 · Cited by 28
Transcriptome Landscape of Cancer‐Associated Fibroblasts in Human PDAC
Tao, M., Liu, W., Chen, J., Liu, R., Zou, J., Yu, B., Wang, C., Huang, M., Chen, Q., Zhang, Z., et al. (2025) · Advanced Science · doi:10.1002/advs.202415196 · Cited by 50
Edwards, B. J.-A., Raisch, D. W., Saraykar, S., Sun, M., Hammel, J. A., Tran, H. T., Wehr, N. H., Arabyat, R. M., & West, D. P. (2017) · Drugs in R&D · doi:10.1007/s40268-016-0168-2 · Cited by 35
Therapeutic Targeting Strategies of Cancer Stem Cells in Gastrointestinal Malignancies
Sonbol, M. B., Ahn, D. H., & Bekaii‐Saab, T. (2019) · Biomedicines · doi:10.3390/biomedicines7010017 · Cited by 35
Rahi, S., & Mehan, S. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-01010-1 · Cited by 38
Moving the Needle on Precision Medicine in Pancreatic Cancer
O'Kane, G. M., & Lowery, M. A. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.21.02514 · Cited by 34
Cancer-Associated Fibroblasts in Pancreatic Cancer: Should They Be Deleted or Reeducated?
Qu, C., Wang, Q., Meng, Z., & Wang, P. (2018) · Integrative Cancer Therapies · doi:10.1177/1534735418794884 · Cited by 34
Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma
Skorupan, N., Domínguez, M. P., Ricci, S. L., & Alewine, C. (2022) · Cancers · doi:10.3390/cancers14174209 · Cited by 35
What treatment in 2017 for inoperable pancreatic cancers?
Taı̈eb, J., Pointet, A., Laethem, J. V., Laquente, B., Pernot, S., Lordick, F., & Reni, M. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx174 · Cited by 33
Wang, J., Chan, D. K. W., Sen, A., Ma, W. W., & Straubinger, R. M. (2019) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-0354 · Cited by 32
From Genetic Alterations to Tumor Microenvironment: The Ariadne’s String in Pancreatic Cancer
Bazzichetto, C., Conciatori, F., Luchini, C., Simionato, F., Santoro, R., Vaccaro, V., Corbo, V., Falcone, I., Ferretti, G., Cognetti, F., et al. (2020) · Cells · doi:10.3390/cells9020309 · Cited by 32
Turaga, R. C., Sharma, M., Mishra, F., Krasinskas, A. M., Yuan, Y., Yang, J. J., Wang, S., Liu, C., Li, S., & Liu, Z. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.08.004 · Cited by 33
Samain, R., Brunel, A., Douché, T., Fanjul, M., Cassant‐Sourdy, S., Rochotte, J., Cros, J. F., Neuzillet, C., Raffenne, J., Duluc, C., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.01.008 · Cited by 32
Hassan, S., Awasthi, N., Ponna, S., & von Holzen, U. W. (2023) · Biomedicines · doi:10.3390/biomedicines11072000 · Cited by 31
Stathis, A., Hess, D., von Moos, R., Homicskó, K., Griguolo, G., Joerger, M., Mark, M. T., Ackermann, C. J., Allegrini, S., Catapano, C. V., et al. (2017) · Investigational New Drugs · doi:10.1007/s10637-017-0454-z · Cited by 32
Sun, Y., Wang, R., Qiao, M., Yan-chun, X., Guan, W., & Wang, L. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26433 · Cited by 32
Stress responses in stromal cells and tumor homeostasis
Vitale, I., Manic, G., Galassi, C., & Galluzzi, L. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.04.004 · Cited by 33
Desmoplasia and Biophysics in Pancreatic Ductal Adenocarcinoma
Maggio, F. D., & El-Shakankery, K. H. (2020) · Pancreas · doi:10.1097/mpa.0000000000001504 · Cited by 33
Yu, S., Lu, Y., Su, A., Chen, J., Li, J., Zhou, B., Liu, X., Xia, Q., Li, Y., Li, J., et al. (2021) · Advanced Science · doi:10.1002/advs.202101848 · Cited by 32
Self-citationIdentification, Culture and Targeting of Cancer Stem Cells
Herreros‐Pomares, A. (2022) · Life · doi:10.3390/life12020184 · Cited by 34
Ligand-dependent Hedgehog pathway activation in Rhabdomyosarcoma: the oncogenic role of the ligands
Almazán-Moga, A., Zarzosa, P., Molist, C., Velasco, P., Pyczek, J., Simon‐Keller, K., Giralt, I., Vidal, I., Navarro, N., Segura, M. F., et al. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.305 · Cited by 32
Overcoming the Fibrotic Fortress in Pancreatic Ductal Adenocarcinoma: Challenges and Opportunities
Min, K. K. M., Ffrench, C. B., Jessup, C. F., Shepherdson, M., Barreto, S. G., & Bonder, C. S. (2023) · Cancers · doi:10.3390/cancers15082354 · Cited by 35
Novel agents for advanced pancreatic cancer
Akinleye, A., Iragavarapu, C., Furqan, M., Cang, S., & Liu, D. (2015) · Oncotarget · doi:10.18632/oncotarget.3999 · Cited by 31
Han, L., Jiang, J., Ma, Q., Wu, Z., & Wang, Z. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4363 · Cited by 31
Shattering the castle walls: Anti-stromal therapy for pancreatic cancer
Kanat, Ö., & Ertaş, H. (2018) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v10.i8.202 · Cited by 31
Han, X., Zhang, W.-H., Wang, W., Yu, X., & Liu, L. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188444 · Cited by 31
Askan, G., Şahin, İ. H., Chou, J. F., Yavas, A., Capanu, M., Iacobuzio–Donahue, C. A., Baştürk, O., & O'Reilly, E. M. (2021) · BMC Cancer · doi:10.1186/s12885-021-08123-w · Cited by 31
Curran, T. (2018) · Open Biology · doi:10.1098/rsob.180098 · Cited by 30
Fibroblast Reprogramming in Gastrointestinal Cancer
Melissari, M., Chalkidi, N., Sarris, M. E., & Koliaraki, V. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00630 · Cited by 30
Strapcova, S., Takáčová, M., Csáderová, L., Martinelli, P., Lukáčiková, Ľ., Gál, V., Kopáček, J., & Švastová, E. (2020) · Cancers · doi:10.3390/cancers12082005 · Cited by 30
Nanoparticle combination for precise stroma modulation and improved delivery for pancreatic cancer
Tarannum, M., Holtzman, K., Dréau, D., Mukherjee, P., & Vivero-Escoto, J. L. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.019 · Cited by 30
Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies
Galperin, I., Dempwolff, L., Diederich, W. E., & Lauth, M. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00188 · Cited by 29
GPCRs in pancreatic adenocarcinoma: Contributors to tumour biology and novel therapeutic targets
Sriram, K., Salmerón, C., Wiley, S. Z., & Insel, P. A. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15028 · Cited by 29
Stoica, A.-F., Chang, C., & Pauklin, S. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.09.008 · Cited by 30
Advances in Targeted Therapy and Immunotherapy for Pancreatic Cancer
Liu, X., Li, Z., & Wang, Y. (2021) · Advanced Biology · doi:10.1002/adbi.201900236 · Cited by 29
Yu, Q., Jobin, C., & Thomas, R. M. (2021) · Neoplasia · doi:10.1016/j.neo.2020.12.008 · Cited by 31
Targeting Tumour-Associated Fibroblasts in Cancers
Shah, K., Mallik, S. B., Gupta, P. K., & Iyer, A. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.908156 · Cited by 31
Shi, Y.-H., Xu, Q., Zhu, Y., Liu, Z., Zhao, G., Liu, Q., Wang, X.-Y., Wang, J., Xu, X. S., Su, Q., et al. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.11.004 · Cited by 29
Self-citationHPV+ve/−ve oral-tongue cancer stem cells: A potential target for relapse-free therapy
Gupta, S., Kumar, P., & Das, B. C. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100919 · Cited by 29
Self-citationMiyabayashi, K., Nakagawa, H., & Koike, K. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.682872 · Cited by 28
Thiery, J. (2022) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2022.00103 · Cited by 29
Micelle Mixtures for Coadministration of Gemcitabine and GDC-0449 To Treat Pancreatic Cancer
Karaca, M., Dutta, R., Özsoy, Y., & Mahato, R. I. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00971 · Cited by 28
Emerging from their burrow: Hedgehog pathway inhibitors for cancer
Gan, G. N., & Jimeno, A. (2016) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2016.1216973 · Cited by 28
Onishi, H., Fujimura, A., Oyama, Y., Yamasaki, A., Imaizumi, A., Kawamoto, M., Katano, M., Umebayashi, M., & Morisaki, T. (2016) · Cellular Immunology · doi:10.1016/j.cellimm.2016.08.003 · Cited by 28
Pharmacotherapeutic strategies for treating pancreatic cancer: advances and challenges
Diab, M., Azmi, A. S., Mohammad, R. M., & Philip, P. A. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1561869 · Cited by 28
Olaoba, O. T., Yang, M. J., Adelusi, T. I., Maidens, T., Kimchi, E. T., Staveley-O’Carroll, K. F., & Li, G. (2024) · Cancers · doi:10.3390/cancers16081470 · Cited by 28
Pancreatic cancer from bench to bedside: molecular pathways and treatment options
Kosmidis, C. S., Sapalidis, K. G., Kotidis, E. V., Mixalopoulos, N., Zarogoulidis, P., Tsavlis, D., Baka, S., Man, Y.-G., & Kanellos, J. (2016) · Annals of Translational Medicine · doi:10.21037/atm.2016.05.11 · Cited by 26
Deciphering the Role of Innate Immune NF-ĸB Pathway in Pancreatic Cancer
Khurana, N., Dodhiawala, P. B., Bulle, A. S., & Lim, K. (2020) · Cancers · doi:10.3390/cancers12092675 · Cited by 27
Chai, J. Y., Sugumar, V., Al-Shanon, A. F., Wong, W. F., Fung, S. Y., & Looi, C. Y. (2021) · Cancers · doi:10.3390/cancers13194746 · Cited by 30
Small molecule tyrosine kinase inhibitors and pancreatic cancer—Trials and troubles
Bhaskar, L. V., Farran, B., Lakkakula, S., Peela, S., Yarla, N. S., Bramhachari, P. V., Kamal, M. A., Saddala, M. S., & Nagaraju, G. P. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.09.011 · Cited by 26
Immunological combination treatment holds the key to improving survival in pancreatic cancer
Sodergren, M. H., Mangal, N., Wasan, H. S., Sadanandam, A., Balachandran, V. P., Jiao, L. R., & Habib, N. (2020) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-020-03332-5 · Cited by 25
Yan, B., Liu, L., Zhao, L., Hinz, U., Luo, Y., An, X., Gladkich, J., Torre, C. D. L., Huang, Z., Schrapel, D., et al. (2022) · Matrix Biology · doi:10.1016/j.matbio.2022.11.002 · Cited by 26
Precision treatment of pancreatic ductal adenocarcinoma
Wei, H., & Ren, H. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216636 · Cited by 25
Maddipati, R. (2025) · Journal of Clinical Investigation · doi:10.1172/jci191943 · Cited by 31
Insights into the relevance of targeting fibroblasts to control cancer
Boeker, V., & Kalluri, R. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102395 · Cited by 25
Stromal Protein-Mediated Immune Regulation in Digestive Cancers
Gamradt, P., de la Fouchardière, C., & Hennino, A. (2021) · Cancers · doi:10.3390/cancers13010146 · Cited by 27
Guo, P., Chen, Q., Peng, K., Xie, J., Liu, J., Ren, W., Tong, Z., Li, M., Xu, J., Zhang, Y., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02308-8 · Cited by 25
Neuzillet, C., Rousseau, B., Kocher, H. M., Bourget, P., & Tournigand, C. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.028 · Cited by 25
How does the tumor microenvironment play a role in hepatobiliary tumors?
Kamil, F., & Rowe, J. H. (2018) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo.2017.06.09 · Cited by 25
Reviewing the Utility of EUS FNA to Advance Precision Medicine in Pancreatic Cancer
Berry, W., Lundy, J., Croagh, D. G., & Jenkins, B. J. (2018) · Cancers · doi:10.3390/cancers10020035 · Cited by 27
Stroma — A Double-Edged Sword in Pancreatic Cancer
Gu, J., Saiyin, H., Fu, D., & Li, J. (2018) · Pancreas · doi:10.1097/mpa.0000000000001023 · Cited by 24
Molecular ZIP codes in targeted drug delivery
Ruoslahti, E. I. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2200183119 · Cited by 28
Mechanoregulation of Metastasis beyond the Matrix
Er, E. E., Tello‐Lafoz, M., & Huse, M. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-0419 · Cited by 22
Kuznetsova, A. V., Попова, О. П., Panchenkov, D. N., Dyuzheva, Т. G., & Aa, I. (2022) · Clinical and Experimental Medicine · doi:10.1007/s10238-022-00886-1 · Cited by 24
KRAS as a Key Oncogene in the Clinical Precision Diagnosis and Treatment of Pancreatic Cancer
Dai, M., Chen, S., Teng, X., Chen, K., & Cheng, W. (2022) · Journal of Cancer · doi:10.7150/jca.76695 · Cited by 28
Gutierrez, N. M. C., Pujol‐Solé, N., Arifi, Q., Coll, J., Clainche, T. L., & Broekgaarden, M. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10064-0 · Cited by 25
Ayasun, R., Saridogan, T., Gaber, O., & Şahin, İ. H. (2022) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2022.11.001 · Cited by 22
Reflections on depletion of tumor stroma in pancreatic cancer
Wang, W.-Q., Liu, L., Xu, J.-Z., & Yu, X. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.01.007 · Cited by 24
Medical management of pancreatic cancer: from personalization to broadening treatment strategies
Dusetti, N., Bachet, J., Chanez, B., Neuzillet, C., de Mestier, L., Williet, N., Frauhoffer, N., Nicolle, R., Boilève, A., Turpin, A., et al. (2025) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2025.102973 · Cited by 28
Phase 1 trial of Vismodegib and Erlotinib combination in metastatic pancreatic cancer
McCleary‐Wheeler, A. L., Carr, R. M., Palmer, S. R., Smyrk, T. C., Allred, J. B., Almada, L. L., Tolosa, E. J., Lamberti, M. J., Marks, D. L., Borad, M. J., et al. (2019) · Pancreatology · doi:10.1016/j.pan.2019.11.011 · Cited by 23
Selecting the optimal parameters for sonoporation of pancreatic cancer in a pre-clinical model
Schultz, C. W., Ponce, G. R. D. G., Langer, A., Liu, J., Dhir, T., Leitch, C., Wessner, C. E., Safont, M. M., Zhang, B., Popa, M. L., et al. (2021) · Cancer Biology & Therapy · doi:10.1080/15384047.2021.1881026 · Cited by 23
Schlick, K., Kiem, D., & Greil, R. (2021) · Biomolecules · doi:10.3390/biom11101469 · Cited by 24
Tanaka, H. Y., Nakazawa, T., Miyazaki, T., Cabral, H., Masamune, A., & Kano, M. R. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.03.041 · Cited by 25
Recent Advances and Prospects for Multimodality Therapy in Pancreatic Cancer
Chadha, A. S., Khoo, A., Aliru, M. L., Arora, H. K., Gunther, J. R., & Krishnan, S. (2016) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2016.05.002 · Cited by 23
Targeting inflammation in pancreatic cancer: Clinical translation
Steele, C. W., Gill, N. A. K., Jamieson, N. B., & Carter, C. R. (2016) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v8.i4.380 · Cited by 23
Metadata
- Authors
- Catenacci, D. V. T., Junttila, M. R., Karrison, T., Bahary, N., Horiba, M. N., Nattam, S. R., Marsh, R., Wallace, J., Kozloff, M., Rajdev, L., Cohen, D., Wade, J., Sleckman, B., Lenz, H.-J., Stiff, P., Kumar, P., Xu, P., Henderson, L., Takebe, N., Salgia, R., Wang, X., Stadler, W. M., de Sauvage, F. J., & Kindler, H. L.
- Affiliations
- Loyola University Medical Center (US)
- Daniel V.T. Catenacci, Theodore Karrison, James Wallace, Mark Kozloff, Peng Xu, Les Henderson, Ravi Salgia, Walter M. Stadler, Hedy L. Kindler, University of Chicago Medical Center; Patrick Stiff, Loyola University Medical Center, Chicago; Robert Marsh, Northshore University Health System, Evanston; James Wallace, Mark Kozloff, Ingalls Hospital, Harvey; James Wade, Decatur Memorial Hospital, Decatur; Pankaj Kumar, Oncology/Hematology Associates, Peoria, IL; Melissa R. Junttila, Xi Wang, and Frederic J....
- Corresponding author
- Catenacci, Daniel V.T.
- ORCID
- Venue
- Journal of Clinical Oncology
- Published
- 2015-12-20
- Volume
- 33
- Issue
- 36
- Pages
- 4284-4292
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- PMC
- PMC4678179
- OpenAlex
- W2137357003
- Cited by
- 561
- References
- 55
- Citations by year
- 2026: 40 · 2025: 36 · 2024: 38 · 2023: 47 · 2022: 71 · 2021: 72 · 2020: 67 · 2019: 65 · 2018: 60 · 2017: 41 · 2016: 20 · 2015: 3
- FWCI
- 18.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Journal of Clinical Oncology (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- European Society for Medical Oncology
- National Institutes of Health (UL1TR000430, n01cm62201-16-0-1)
- Genentech
- National Cancer Institute (N01 CM062201, N01 CM-62201)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- metastatic pancreatic cancer, gemcitabine, vismodegib, sonic hedgehog pathway, Smoothened inhibition, Hedgehog pathway inhibitors, progression-free survival, overall survival, KRAS G12D, p53, drug safety, combination therapy
- MeSH terms
- Gemcitabine, Adult, Aged, Anilides, Animals, Antineoplastic Combined Chemotherapy Protocols, Deoxycytidine, Female, Humans, Male, Middle Aged, Neoplasm Staging, Pancreatic Neoplasms, Pyridines, Signal Transduction, Odds Ratio, Treatment Outcome, Karnofsky Performance Status, Disease-Free Survival, Mice, Kaplan-Meier Estimate, Hedgehog Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review