The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Evaluating Cancer of the Central Nervous System Through Next-Generation Sequencing of Cerebrospinal Fluid
Open accessAbstract
Purpose: Cancer spread to the central nervous system (CNS) often is diagnosed late and is unresponsive to therapy. Mechanisms of tumor dissemination and evolution within the CNS are largely unknown because of limited access to tumor tissue. Materials and Methods: We sequenced 341 cancer-associated genes in cell-free DNA from cerebrospinal fluid (CSF) obtained through routine lumbar puncture in 53 patients with suspected or known CNS involvement by cancer. Results: We detected high-confidence somatic alterations in 63% (20 of 32) of patients with CNS metastases of solid tumors, 50% (six of 12) of patients with primary brain tumors, and 0% (zero of nine) of patients without CNS involvement by cancer. Several patients with tumor progression in the CNS during therapy with inhibitors of oncogenic kinases harbored mutations in the kinase target or kinase bypass pathways. In patients with glioma, the most common malignant primary brain tumor in adults, examination of cell-free DNA uncovered patterns of tumor evolution, including temozolomide-associated mutations. Conclusion: The study shows that CSF harbors clinically relevant genomic alterations in patients with CNS cancers and should be considered for liquid biopsies to monitor tumor evolution in the CNS.
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A framework for variation discovery and genotyping using next-generation DNA sequencing data
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Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
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An integrated map of genetic variation from 1,092 human genomes
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Aldape, K., Brindle, K. M., Chesler, L., Chopra, R., Gajjar, A., Gilbert, M. R., Gottardo, N., Gutmann, D. H., Hargrave, D., Holland, E. C., et al. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0177-5 · Cited by 959
Self-citationGlioblastoma targeted therapy: updated approaches from recent biological insights
Touat, M., Idbaih, A., Sanson, M., & Ligon, K. L. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx106 · Cited by 441
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Tivey, A., Church, M., Rothwell, D., Dive, C., & Cook, N. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00660-y · Cited by 321
The Evolving Landscape of Brain Metastasis
Valiente, M., Ahluwalia, M. S., Boire, A., Brastianos, P. K., Goldberg, S. B., Lee, E. Q., Le Rhun, E., Preusser, M., Winkler, F., & Soffietti, R. (2018) · Trends in Cancer · doi:10.1016/j.trecan.2018.01.003 · Cited by 309
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Metadata
- Authors
- Pentsova, E. I., Shah, R. H., Tang, J., Boire, A., You, D., Briggs, S., Omuro, A., Lin, X., Fleisher, M., Grommes, C., Panageas, K. S., Meng, F., Selcuklu, S. D., Ogilvie, S., Distefano, N., Shagabayeva, L., Rosenblum, M., DeAngelis, L. M., Viale, A., Mellinghoff, I. K., & Berger, M. F.
- Venue
- Journal of Clinical Oncology
- Published
- 2016-07-10
- Volume
- 34
- Issue
- 20
- Pages
- 2404-2415
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2373239564
- Cited by
- 417
- References
- 64
- FWCI
- 14.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Pentsova, E. I., Shah, R. H., Tang, J., Boire, A., You, D., Briggs, S., Omuro, A., Lin, X., Fleisher, M., Grommes, C., Panageas, K. S., Meng, F., Selcuklu, S. D., Ogilvie, S., Distefano, N., Shagabayeva, L., Rosenblum, M., DeAngelis, L. M., Viale, A., . . . Berger, M. F. (2016). Evaluating Cancer of the Central Nervous System Through Next-Generation Sequencing of Cerebrospinal Fluid. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2016.66.6487
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
