Challenges to curing primary brain tumours
Open accessAbstract
Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.
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Cites
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
Louis, D. N., Perry, A., Reifenberger, G., von Deimling, A., Figarella‐Branger, D., Cavenee, W. K., Ohgaki, H., Wiestler, O. D., Kleihues, P., & Ellison, D. W. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1545-1 · Cited by 15,703 · see citing works
The 2007 WHO Classification of Tumours of the Central Nervous System
Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., Scheithauer, B. W., & Kleihues, P. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0243-4 · Cited by 15,422 · see citing works
Microenvironmental regulation of tumor progression and metastasis
Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994 · see citing works
Self-citationIdentification of human brain tumour initiating cells
Singh, S. K., Hawkins, C. E., Clarke, I. D., Squire, J. A., Bayani, J., Hide, T., Henkelman, R. M., Cusimano, M. D., & Dirks, P. B. (2004) · Nature · doi:10.1038/nature03128 · Cited by 7,388 · see citing works
Astrocyte-endothelial interactions at the blood-brain barrier
Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595 · see citing works
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175 · see citing works
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Patel, A. P., Tirosh, I., Trombetta, J. J., Shalek, A. K., Gillespie, S. M., Wakimoto, H., Cahill, D. P., Nahed, B. V., Curry, W. T., Martuza, R. L., et al. (2014) · Science · doi:10.1126/science.1254257 · Cited by 5,063 · see citing works
Wen, P. Y., Macdonald, D. R., Reardon, D. A., Cloughesy, T. F., Sorensen, A. G., Galanis, E., DeGroot, J. F., Wick, W., Gilbert, M. R., Lassman, A. B., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.26.3541 · Cited by 3,814 · see citing works
Self-citationDNA methylation-based classification of central nervous system tumours
Capper, D., Jones, D., Sill, M., Hovestadt, V., Schrimpf, D., Sturm, D., Koelsche, C., Sahm, F., Chávez, L., Reuß, D., et al. (2018) · Nature · doi:10.1038/nature26000 · Cited by 3,046 · see citing works
Self-citationA Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma
Gilbert, M. R., Dignam, J. J., Armstrong, T. S., Wefel, J. S., Blumenthal, D. T., Vogelbaum, M. A., Colman, H., Chakravarti, A., Pugh, S., Won, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1308573 · Cited by 2,834 · see citing works
Self-citationLiquid biopsies come of age: Towards implementation of circulating tumour DNA
Wan, J. C. M., Massie, C., Garcia-Corbacho, J., Mouliere, F., Brenton, J. D., Caldas, C., Pacey, S., Baird, R., & Rosenfeld, N. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.7 · Cited by 2,809 · see citing works
The blood-brain barrier/neurovascular unit in health and disease
Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661 · see citing works
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Schwartzentruber, J., Korshunov, A., Liu, X.-Y., Jones, D. T. W., Pfaff, E., Jacob, K., Sturm, D., Fontebasso, A. M., Quang, D.-A. K., Tönjes, M., et al. (2012) · Nature · doi:10.1038/nature10833 · Cited by 2,631 · see citing works
Self-citationBevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma
Chinot, O. L., Wick, W., Mason, W. P., Henriksson, R., Saran, F. H., Nishikawa, R., Carpentier, A. F., Hoang‐Xuan, K., Kavan, P., Cernea, D. M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1308345 · Cited by 2,565 · see citing works
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475 · see citing works
A Perivascular Niche for Brain Tumor Stem Cells
Calabrese, C. R., Poppleton, H., Koçak, M., Hogg, T. L., Fuller, C. E., Hamner, J. B., Oh, E. Y., Gaber, M. W., Finklestein, D., Allen, M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.11.020 · Cited by 2,203 · see citing works
Self-citationPericytes are required for blood–brain barrier integrity during embryogenesis
Daneman, R., Zhou, L., Kebede, A. A., & Barres, B. A. (2010) · Nature · doi:10.1038/nature09513 · Cited by 2,128 · see citing works
A restricted cell population propagates glioblastoma growth after chemotherapy
Chen, J., Li, Y., Yu, T.-S., McKay, R. M., Burns, D. K., Kernie, S. G., & Parada, L. F. (2012) · Nature · doi:10.1038/nature11287 · Cited by 2,096 · see citing works
A molecular atlas of cell types and zonation in the brain vasculature
Vanlandewijck, M., He, L., Mäe, M. A., Andrae, J., Ando, K., Del Gaudio, F., Nahar, K., Lebouvier, T., Laviña, B., Gouveia, L., et al. (2018) · Nature · doi:10.1038/nature25739 · Cited by 2,074 · see citing works
The Microenvironmental Landscape of Brain Tumors
Quail, D. F., & Joyce, J. A. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.02.009 · Cited by 1,875 · see citing works
Self-citationAltered Neural Cell Fates and Medulloblastoma in Mouse <i>patched</i> Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696 · see citing works
The role of microglia and macrophages in glioma maintenance and progression
Hambardzumyan, D., Gutmann, D. H., & Kettenmann, H. (2016) · Nature Neuroscience · doi:10.1038/nn.4185 · Cited by 1,683 · see citing works
Self-citationCancer stem cells in glioblastomaPreprint
Lathia, J. D., Mack, S. C., Mulkearns-Hubert, E. E., Valentim, C. L. L., & Rich, J. N. (2015) · Genes & Development · doi:10.1101/gad.261982.115 · Cited by 1,600 · see citing works
Self-citationDeep mutational scanning: a new style of protein science
Fowler, D. M., & Fields, S. (2014) · Nature Methods · doi:10.1038/nmeth.3027 · Cited by 1,287 · see citing works
Pajtler, K. W., Witt, H., Sill, M., Jones, D., Hovestadt, V., Kratochwil, F., Wani, K., Tatevossian, R., Punchihewa, C., Johann, P. D., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.04.002 · Cited by 1,224 · see citing works
Self-citationSingle-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
Tirosh, I., Venteicher, A. S., Hebert, C. M., Escalante, L. E., Patel, A. P., Yizhak, K., Fisher, J. M., Rodman, C., Mount, C., Filbin, M. G., et al. (2016) · Nature · doi:10.1038/nature20123 · Cited by 1,216 · see citing works
Mackay, A., Burford, A., Carvalho, D., Izquierdo, E., Fazal-Salom, J., Taylor, K. R., Bjerke, L., Clarke, M., Vinci, M., Nandhabalan, M., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.08.017 · Cited by 1,212 · see citing works
Self-citationFrom blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery
Banks, W. A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.21 · Cited by 1,204 · see citing works
Darmanis, S., Sloan, S. A., Croote, D., Mignardi, M., Chernikova, S. B., Samghababi, P., Zhang, Y., Neff, N. F., Kowarsky, M., Caneda, C., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.030 · Cited by 1,004 · see citing works
Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis
Krueger, D. A., Caré, M. M., Holland, K. D., Agricola, K. D., Tudor, C., Mangeshkar, P., Wilson, K. A., Byars, A. W., Sahmoud, T., & Franz, D. N. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1001671 · Cited by 1,003 · see citing works
Ignatova, T. N., Kukekov, V. G., Laywell, E. D., Suslov, O. N., Vrionis, F. D., & Steindler, D. A. (2002) · Glia · doi:10.1002/glia.10094 · Cited by 992 · see citing works
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
Sturm, D., Orr, B. A., Toprak, U. H., Hovestadt, V., Jones, D., Capper, D., Sill, M., Buchhalter, I., Northcott, P. A., Irina, L., et al. (2016) · Cell · doi:10.1016/j.cell.2016.01.015 · Cited by 979 · see citing works
Self-citationDuffner, P. K., Horowitz, M. E., Krischer, J. P., Friedman, H. S., Burger, P. C., Cohen, M. E., Sanford, R. A., Mulhern, R. K., James, H. E., Freeman, C. R., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199306173282401 · Cited by 839 · see citing works
Radial glia cells are candidate stem cells of ependymoma
Taylor, M. D., Poppleton, H., Fuller, C. E., Su, X., Liu, Y., Jensen, P., Magdaleno, S. M., Dalton, J., Calabrese, C. R., Julian Board, et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.09.001 · Cited by 826 · see citing works
Self-citationSubtypes of medulloblastoma have distinct developmental origins
Gibson, P., Tong, Y., Robinson, G. W., Thompson, M. C., Currle, D. S., Eden, C. O., Kranenburg, T. A., Hogg, T. L., Poppleton, H., Martin, J. M., et al. (2010) · Nature · doi:10.1038/nature09587 · Cited by 824 · see citing works
Self-citationTransforming Fusions of FGFR and TACC Genes in Human Glioblastoma
Singh, D., Chan, J., Zoppoli, P., Niola, F., Sullivan, R., Castano, A. M., Liu, E., Reichel, J. B., Porrati, P., Pellegatta, S., et al. (2012) · Science · doi:10.1126/science.1220834 · Cited by 777 · see citing works
Self-citationZacharakis, N., Chinnasamy, H., Black, M. A., Xu, H., Lu, Y., Zheng, Z., Pasetto, A., Langhan, M. M., Shelton, T. E., Prickett, T. D., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0040-8 · Cited by 770 · see citing works
Clonal evolution of glioblastoma under therapy
Wang, J., Cazzato, E., Ladewig, E., Frattini, V., Rosenbloom, D. I. S., Zairis, S., Abate, F., Liu, Z., Elliott, O., Shin, Y., et al. (2016) · Nature Genetics · doi:10.1038/ng.3590 · Cited by 759 · see citing works
Comprehensive Analysis of Hypermutation in Human Cancer
Campbell, B. B., Light, N. D., Fabrizio, D. A., Zatzman, M., Fuligni, F., de Borja, R., Davidson, S., Edwards, M., Elvin, J. A., Hodel, K. P., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.048 · Cited by 759 · see citing works
Self-citationClinical trial of blood-brain barrier disruption by pulsed ultrasound
Carpentier, A., Canney, M., Vignot, A., Reina, V., Beccaria, K., Horodyckid, C., Karachi, C., Leclercq, D., Lafon, C., Chapelon, J.-Y., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf6086 · Cited by 757 · see citing works
Revisiting the Mechanisms of CNS Immune Privilege
Louveau, A., Harris, T. H., & Kipnis, J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.006 · Cited by 682 · see citing works
Hubert, C. G., Rivera, M., Spangler, L. C., Wu, Q., Mack, S. C., Prager, B. C., Couce, M., McLendon, R. E., Sloan, A. E., & Rich, J. N. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2402 · Cited by 673 · see citing works
Self-citationC11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma
Parker, M. D., Mohankumar, K. M., Punchihewa, C., Weinlich, R., Dalton, J., Li, Y., Lee, R. P., Tatevossian, R., Phoenix, T. N., Thiruvenkatam, R., et al. (2014) · Nature · doi:10.1038/nature13109 · Cited by 668 · see citing works
Self-citationMedulloblastomics: the end of the beginning
Northcott, P. A., Jones, D., Kool, M., Robinson, G. W., Gilbertson, R. J., Cho, Y., Pomeroy, S. L., Korshunov, A., Lichter, P., Taylor, M. D., et al. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3410 · Cited by 661 · see citing works
Self-citationEnhancer hijacking activates GFI1 family oncogenes in medulloblastoma
Northcott, P. A., Lee, C., Zichner, T., Stütz, A. M., Erkek, S., Kawauchi, D., Shih, D. J. H., Hovestadt, V., Zapatka, M., Sturm, D., et al. (2014) · Nature · doi:10.1038/nature13379 · Cited by 642 · see citing works
Self-citationGlioblastoma: pathology, molecular mechanisms and markers
Aldape, K., Zadeh, G., Mansouri, S., Reifenberger, G., & von Deimling, A. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1432-1 · Cited by 621 · see citing works
Self-citationPacker, R. J., Goldwein, J. L., Nicholson, H. S., Vezina, L. G., Allen, J. C., Ris, M. D., Muraszko, K. M., RORKE, L. B., Wara, W. M., Cohen, B. H., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.7.2127 · Cited by 616 · see citing works
The Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis
Lim, D. A., & Alvarez-Buylla, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018820 · Cited by 571 · see citing works
Ater, J. L., Zhou, T., Holmes, E. J., Mazewski, C., Booth, T. N., Freyer, D. R., Lazarus, K. H., Packer, R. J., Prados, M. D., Sposto, R., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.36.6054 · Cited by 435 · see citing works
Geyer, J. R., Sposto, R., Jennings, M. T., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.09.095 · Cited by 434 · see citing works
Pentsova, E. I., Shah, R. H., Tang, J., Boire, A. A., You, D., Briggs, S. R., Omuro, A. M. P., Lin, X., Fleisher, M., Grommes, C., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.66.6487 · Cited by 415 · see citing works
Self-citationClonal selection drives genetic divergence of metastatic medulloblastoma
Wu, X., Northcott, P. A., Dubuc, A. M., Dupuy, A. J., Shih, D. J. H., Witt, H., Croul, S. E., Bouffet, É., Fults, D. W., Eberhart, C. G., et al. (2012) · Nature · doi:10.1038/nature10825 · Cited by 408 · see citing works
Self-citationGraeber, M. B., Scheithauer, B. W., & Kreutzberg, G. W. (2002) · Glia · doi:10.1002/glia.10147 · Cited by 387 · see citing works
Corticosteroids compromise survival in glioblastoma
Pitter, K. L., Tamagno, I., Alikhanyan, K., Hosni-Ahmed, A., Pattwell, S. S., Donnola, S. B., Dai, C. S., Ozawa, T., Chang, M., Chan, T. A.-T., et al. (2016) · Brain · doi:10.1093/brain/aww046 · Cited by 364 · see citing works
Self-citationCross-species genomics matches driver mutations and cell compartments to model ependymoma
Johnson, R. A., Wright, K. D., Poppleton, H., Mohankumar, K. M., Finkelstein, D., Pounds, S. B., Rand, V., Leary, S. E. S., White, E. L., Eden, C., et al. (2010) · Nature · doi:10.1038/nature09173 · Cited by 363 · see citing works
Self-citationMedulloblastoma Genotype Dictates Blood Brain Barrier Phenotype
Phoenix, T. N., Patmore, D. M., Boop, S. H., Boulos, N., Jacus, M. O., Patel, Y. T., Roussel, M. F., Finkelstein, D., Goumnerova, L. C., Perreault, S., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.03.002 · Cited by 352 · see citing works
Self-citationPajtler, K. W., Mack, S. C., Ramaswamy, V., Smith, C. A., Witt, H., Smith, A., Hansford, J. R., von Hoff, K., Wright, K. D., Hwang, E. I., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1643-0 · Cited by 337 · see citing works
Self-citationDivergent clonal selection dominates medulloblastoma at recurrence
Morrissy, A. S., Garzia, L., Shih, D. J. H., Zuyderduyn, S., Huang, X., Skowron, P., Remke, M., Cavalli, F. M. G., Ramaswamy, V., Lindsay, P. E., et al. (2016) · Nature · doi:10.1038/nature16478 · Cited by 329 · see citing works
Self-citationGerstner, E. R., & Fine, R. L. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.10.0677 · Cited by 266 · see citing works
Immune Evasion Strategies of Glioblastoma
Razavi, S., Lee, K. E., Jin, B. E., Aujla, P. S., Gholamin, S., & Li, G. (2016) · Frontiers in Surgery · doi:10.3389/fsurg.2016.00011 · Cited by 264 · see citing works
Griveau, A., Seano, G., Shelton, S. J., Kupp, R., Jahangiri, A., Obernier, K., Krishnan, S., Lindberg, O. R., Yuen, T. J., Tien, A., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.020 · Cited by 261 · see citing works
Self-citationAdaptive Global Innovative Learning Environment for Glioblastoma: GBM AGILE
Alexander, B. M., Ba, S., Berger, M. S., Berry, D. A., Cavenee, W. K., Chang, S. M., Cloughesy, T. F., Jiang, T., Khasraw, M., Li, W., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0764 · Cited by 225 · see citing works
Brinkman, T. M., Krasin, M. J., Liu, W., Armstrong, G. T., Ojha, R. P., Sadighi, Z. S., Gupta, P., Kimberg, C., Srivastava, D. K., Merchant, T. E., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.62.2589 · Cited by 212 · see citing works
Self-citationIt Takes a Village: Constructing the Neurogenic Niche
Bjornsson, C. S., Apostolopoulou, M., Tian, Y. I., & Temple, S. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.01.010 · Cited by 210 · see citing works
Toledo, C. M., Ding, Y., Hoellerbauer, P., Davis, R. J., Basom, R., Girard, E. J., Lee, E., Corrin, P. D., Hart, T., Bolouri, H., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.11.021 · Cited by 188 · see citing works
Self-citationC11ORF95-RELA FUSIONS DRIVE ONCOGENIC NF-KB SIGNALING IN EPENDYMOMA
Gilbertson, R. J., Parker, M. D., Mohankumar, K. M., Punchihewa, C., Weinlich, R., Dalton, J. D., Li, Y., Lee, R. P., Tatevossian, R., Phoenix, T. N., et al. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou206.57 · Cited by 173 · see citing works
Self-citationKrishnatry, R., Zhukova, N., Stücklin, A. G., et al. (2016) · Cancer · doi:10.1002/cncr.29907 · Cited by 173 · see citing works
Vaccine-based immunotherapeutic approaches to gliomas and beyond
Weller, M., Roth, P., Preusser, M., Wick, W., Reardon, D. A., Platten, M., & Sampson, J. H. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.64 · Cited by 161 · see citing works
Self-citationRosso, L., Brock, C. S., Gallo, J. M., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2356 · Cited by 160 · see citing works
Day, S. E., Kettunen, M. I., Cherukuri, M. K., et al. (2010) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22698 · Cited by 156 · see citing works
Immunotherapy for Brain Tumors
Sampson, J. H., Maus, M. V., & June, C. H. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.72.8089 · Cited by 155 · see citing works
Self-citationPei, Y., Brun, S. N., Markant, S. L., Lento, W. E., Gibson, P., Taketo, M. M., Giovannini, M., Gilbertson, R. J., & Wechsler‐Reya, R. J. (2012) · Development · doi:10.1242/dev.050104 · Cited by 134 · see citing works
Self-citationCommon variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss
Xu, H., Robinson, G. W., Huang, J., et al. (2015) · Nature Genetics · doi:10.1038/ng.3217 · Cited by 133 · see citing works
Self-citationAdaptive Clinical Trial Design
Chow, S. (2014) · Annual Review of Medicine · doi:10.1146/annurev-med-092012-112310 · Cited by 124 · see citing works
An Integrated In Vitro and In Vivo High-Throughput Screen Identifies Treatment Leads for Ependymoma
Atkinson, J. M., Shelat, A. A., Carcaboso, A. M., Kranenburg, T. A., Arnold, L. A., Boulos, N., Wright, K. D., Johnson, R. A., Poppleton, H., Mohankumar, K. M., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.08.013 · Cited by 115 · see citing works
Self-citationIntellectual Outcome in Molecular Subgroups of Medulloblastoma
Moxon‐Emre, I., Taylor, M. D., Bouffet, É., Hardy, K. K., Campen, C. J., Malkin, D. M., Hawkins, C. E., Laperrière, N., Ramaswamy, V., Bartels, U. K., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.66.9077 · Cited by 94 · see citing works
Self-citationGilbertson, R. (2011) · Cell · doi:10.1016/j.cell.2011.03.019 · Cited by 84 · see citing works
Self-citationAdvances in immunotherapy for the treatment of glioblastoma
Tivnan, A., Heilinger, T., Lavelle, E. C., & Prehn, J. H. M. (2016) · Journal of Neuro-Oncology · doi:10.1007/s11060-016-2299-2 · Cited by 83 · see citing works
Cole, P. D., Finkelstein, Y., Stevenson, K. E., Blonquist, T. M., Vijayanathan, V., Silverman, L. B., Neuberg, D. S., Sallan, S. E., Robaey, P., & Waber, D. P. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.59.0273 · Cited by 76 · see citing works
An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes
Mohankumar, K. M., Currle, D. S., White, E. L., Boulos, N., Dapper, J. D., Eden, C. O., Nimmervoll, B. V., Thiruvenkatam, R., Connelly, M., Kranenburg, T. A., et al. (2015) · Nature Genetics · doi:10.1038/ng.3323 · Cited by 74 · see citing works
Self-citationBrindle, K. M., Izquierdo-García, J. L., Lewis, D. Y., Mair, R. J., & Wright, A. J. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.72.7636 · Cited by 70 · see citing works
Self-citationReinartz, R., Wang, S., Kebir, S., Silver, D. J., Wieland, A., Zheng, T., Kupper, M. D., Rauschenbach, L., Fimmers, R., Shepherd, T. M., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2089 · Cited by 69 · see citing works
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“GBM poses signi fi cant challenges to clinical treatment due to its invasive nature, poor prognosis, and high recurrence rate 231 .”
- Authors
- Aldape, K., Brindle, K. M., Chesler, L., Chopra, R., Gajjar, A., Gilbert, M. R., Gottardo, N., Gutmann, D. H., Hargrave, D., Holland, E. C., Jones, D. T. W., Joyce, J. A., Kearns, P., Kieran, M. W., Mellinghoff, I. K., Merchant, M., Pfister, S. M., Pollard, S. M., Ramaswamy, V., Rich, J. N., Robinson, G. W., Rowitch, D. H., Sampson, J. H., Taylor, M. D., Workman, P., & Gilbertson, R. J.
- Affiliations
- University Health Network (CA)
- Cancer Research UK (GB)
- Institute of Cancer Research (GB)
- St. Jude Children's Research Hospital (US)
- National Institutes of Health (US)
- The Kids Research Institute Australia (AU)
- Washington University in St. Louis (US)
- Great Ormond Street Hospital (GB)
- Fred Hutch Cancer Center (US)
- National Center for Tumor Diseases (DE)
- Ludwig Cancer Research (CH)
- Cancer Research UK Clinical Trials Unit (GB)
- Harvard University (US)
- Memorial Sloan Kettering Cancer Center (US)
- AstraZeneca (United States) (US)
- Edinburgh Cancer Research (GB)
- Hospital for Sick Children (CA)
- University of California San Diego (US)
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- Duke Cancer Institute (US)
- University of Cambridge (GB)
- Corresponding author
- Gilbertson, Richard J.
- ORCID
- Aldape, Kenneth
- Brindle, Kevin M.
- Chesler, Louis
- Gajjar, Amar
- Gilbert, Mark R.
- Gottardo, Nicholas
- Gutmann, David H.
- Hargrave, Darren
- Holland, Eric C.
- Jones, David T. W.
- Joyce, Johanna A.
- Kearns, Pamela
- Kieran, Mark W.
- Mellinghoff, Ingo K.
- Pfister, Stefan M.
- Pollard, Steven M.
- Ramaswamy, Vijay
- Rich, Jeremy N.
- Robinson, Giles W.
- Rowitch, David H.
- Sampson, John H.
- Taylor, Michael D.
- Workman, Paul
- Gilbertson, Richard J.
- Venue
- Nature Reviews Clinical Oncology
- Published
- 2019-02-07
- Volume
- 16
- Issue
- 8
- Pages
- 509-520
- ISSN
- 1759-4774 (ISSN-L)
- 1759-4782
- PMC
- PMC6650350
- OpenAlex
- W2913928134
- Cited by
- 959
- References
- 92
- Citations by year
- 2026: 80 · 2025: 149 · 2024: 155 · 2023: 161 · 2022: 131 · 2021: 161 · 2020: 100 · 2019: 22
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Nature Reviews Clinical Oncology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (acceptedVersion, cc-by)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- UWA Profiles and Research Repository (UWA) (submittedVersion, cc-by)
- UCL Discovery (University College London) (submittedVersion)
- IRIS (submittedVersion, cc-by)
- SERVAL (Université de Lausanne) (submittedVersion, cc-by)
- Apollo (cc-by)
- Funders
- Cancer Research UK (22492, 28667, 26398, 21992, C197/A28667, 17242, 22897, R0CA1129541, 28028, P01CA96832, 28289, 27413, 15958, 17368)
- Brain Tumour Charity (16/193, GN-000358)
- National Institutes of Health (R0CA1129541, Z99 CA999999, P01CA96832)
- Medical Research Council (MC_PC_12009)
- National Cancer Institute (R01CA116659, R35CA197718, R01CA129958, P30CA008748, P01CA096832, P30CA014236)
- National Institute of Neurological Disorders and Stroke (K02NS047409, R01NS089272)
- Topics
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Brain Metastases and Treatment
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- primary brain tumors, treatment resistance, tumor microenvironment, nervous tissue
- MeSH terms
- Brain Neoplasms, Humans
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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