The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Bayesian Adaptive Randomization Trial of Passive Scattering Proton Therapy and Intensity-Modulated Photon Radiotherapy for Locally Advanced Non–Small-Cell Lung Cancer
Open accessAbstract
Purpose: This randomized trial compared outcomes of passive scattering proton therapy (PSPT) versus intensity-modulated (photon) radiotherapy (IMRT), both with concurrent chemotherapy, for inoperable non–small-cell lung cancer (NSCLC). We hypothesized that PSPT exposes less lung tissue to radiation than IMRT and thereby reduces toxicity without compromising tumor control. The primary end points were grade ≥ 3 radiation pneumonitis (RP) and local failure (LF). Patients and Methods: Eligible patients had stage IIB to IIIB NSCLC (or stage IV NSCLC with a single brain metastasis or recurrent lung or mediastinal disease after surgery) who were candidates for concurrent chemoradiation therapy. Pairs of treatment plans for IMRT and PSPT were created for each patient. Patients were eligible for random assignment only if both plans satisfied the same prespecified dose-volume constraints for at-risk organs at the same tumor dose. Results: Compared with IMRT (n = 92), PSPT (n = 57) exposed less lung tissue to doses of 5 to 10 Gy(RBE), which is the absorbed Gy dose multiplied by the relative biologic effectiveness (RBE) factor for protons; exposed more lung tissue to ≥ 20 Gy(RBE), but exposed less heart tissue at all dose levels between 5 and 80 Gy(RBE). The grade ≥ 3 RP rate for all patients was 8.1% (IMRT, 6.5%; PSPT, 10.5%); corresponding LF rates were 10.7% (all), 10.9% (IMRT), and 10.5% (PSPT). The posterior probability of IMRT being better than PSPT was 0.54. Exploratory analysis showed that the RP and LF rates at 12 months for patients enrolled before versus after the trial midpoint were 21.1% (before) versus 18.2% (after) for the IMRT group (P = .047) and 31.0% (before) versus 13.1% (after) for the PSPT group (P = .027). Conclusion: PSPT did not improve dose-volume indices for lung but did for heart. No benefit was noted in RP or LF after PSPT. Improvements in both end points were observed over the course of the trial.
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Self-citationRadiation Dose–Volume Effects in the Lung
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Self-citationLiao, Z. X., Komaki, R. R., Thames, H. D., Liu, H. H., Tucker, S. L., Mohan, R., Martel, M. K., Wei, X., Yang, K., Kim, E. S., et al. (2010) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.02.032 · Cited by 282
Self-citationThe Emergence of the Randomized, Controlled Trial
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Self-citationA methodology for automatic intensity-modulated radiation treatment planning for lung cancer
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Exploring treatment options in cancer: tumor treatment strategies
Liu, B., Zhou, H., Tan, L., Siu, K. T. H., & Guan, X.-Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01856-7 · Cited by 1,201
Contemporary radiotherapy: present and future
Chandra, R. A., Keane, F. K., Voncken, F. E. M., & Thomas, C. R. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00233-6 · Cited by 380
Automatic multiorgan segmentation in thorax CT images using U‐net‐ GAN
Dong, X., Lei, Y., Wang, T., Thomas, M., Tang, L., Curran, W. J., Liu, T., & Yang, X. (2019) · Medical Physics · doi:10.1002/mp.13458 · Cited by 275
Metadata
- Authors
- Liao, Z., Lee, J. J., Komaki, R., Gomez, D. R., O’Reilly, M. S., Fossella, F. V., Blumenschein, G. R., Heymach, J. V., Vaporciyan, A. A., Swisher, S. G., Allen, P. K., Choi, N. C., DeLaney, T. F., Hahn, S. M., Cox, J. D., Lu, C. S., & Mohan, R.
- Venue
- Journal of Clinical Oncology
- Published
- 2018-06-20
- Volume
- 36
- Issue
- 18
- Pages
- 1813-1822
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2781965877
- Cited by
- 336
- References
- 12
- FWCI
- 27.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Liao, Z., Lee, J. J., Komaki, R., Gomez, D. R., O’Reilly, M. S., Fossella, F. V., Blumenschein, G. R., Heymach, J. V., Vaporciyan, A. A., Swisher, S. G., Allen, P. K., Choi, N. C., DeLaney, T. F., Hahn, S. M., Cox, J. D., Lu, C. S., & Mohan, R. (2018). Bayesian Adaptive Randomization Trial of Passive Scattering Proton Therapy and Intensity-Modulated Photon Radiotherapy for Locally Advanced Non–Small-Cell Lung Cancer. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2017.74.0720
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
