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Cited by 125Neonatal and fetal brain pathologyAntioxidant Activity and Oxidative StressMetabolism and Genetic Disorders

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Elevated Free Radical Products in the Cerebrospinal Fluid of VLBW Infants with Cerebral White Matter Injury

Inder, Terrie, Mocatta, Tessa, Darlow, Brian, Spencer, Carole, Volpe, Joseph J, Winterbourn, Christine·2002·Pediatric Research
DOI 10.1203/00006450-200208000-00013
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Abstract

Free radical mediated cellular injury has been hypothesized to play a key role in the pathogenesis of white matter injury in the premature infant, although direct evidence is lacking. Between April 1999 and May 2001, 22 very low birthweight infants, 30 term infants, and 17 adults had samples of cerebrospinal fluid (CSF) collected for clinical indications. Only CSF samples without any evidence of meningeal inflammation were analyzed for the levels of the lipid peroxidation products, 8-isoprostane and malondialdehyde (MDA), and protein carbonyls as a measure of protein oxidation. Chlorotyrosine was monitored as a measure of neutrophil oxidative activity. In the premature infants with subsequent evidence of white matter injury on magnetic resonance imaging at term, there was a significant elevation in the CSF level of protein carbonyls in comparison with the level in healthy premature infants, term infants, and adult controls (all p < 0.001). A significant difference in the levels of the lipid peroxidation products, 8-isoprostane and MDA, was apparent between premature infants with white matter injury and adult controls (isoprostanes p = 0.02, MDA p = 0.014). There was a trend toward higher levels of 8-isoprostane in the premature infants with white matter injury in comparison with those without white matter injury (p = 0.08), with 5 of the 14 infants with white matter injury having levels that were more than 10-fold higher than the top of the adult range. There was no significant difference in the level of chlorotyrosines among any of the groups. These preliminary data provide evidence of an association of elevated oxidative products during the evolution of white matter injury in the human premature infant.

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Crossref · 10.1203/00006450-200208000-00013

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Research works printed but not linked: 2

  1. Armstead WM, 1988, Am J Physiol, 225, H401
  2. Jain M, 2000, Indian Pediatr, 37, 608

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Metadata

Authors
Inder, T., Mocatta, T., Darlow, B., Spencer, C., Volpe, J. J., & Winterbourn, C.
Affiliations
Royal Children's Hospital (AU)
Corresponding author
Inder, Terrie
ORCID
Venue
Pediatric Research
Publisher
Springer Science and Business Media LLC
Published
2002-08
Volume
52
Issue
2
Pages
213-218
ISSN
  • 0031-3998 (ISSN-L)
  • 1530-0447
DOI
10.1203/00006450-200208000-00013
OpenAlex
W2069334549
Cited by
125
References
39
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 6 · 2013: 6 · 2012: 8
FWCI
6.84
Type
journal article
Language
en
Open access
closed
Locations
  • Pediatric Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Neurological Foundation of New Zealand
  • Health Research Council of New Zealand
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
Keywords
very low birth weight infants, cerebral white matter injury, oxidative stress, free radicals, cerebrospinal fluid biomarkers, lipid peroxidation, 8-isoprostane, malondialdehyde, protein carbonyls, chlorotyrosine, neutrophil oxidative activity
MeSH terms
Brain, Free Radicals, Humans, Infant, Newborn, Infant, Premature, Magnetic Resonance Imaging, Nerve Fibers, Lipid Peroxidation, Biomarkers, Linear Models, Oxidative Stress, Infant, Very Low Birth Weight

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