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Cited by 121Birth, Development, and HealthPregnancy and preeclampsia studiesNeonatal Respiratory Health Research

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Fetal Growth Restriction Has Long-Term Effects on Postnatal Lung Structure in Sheep

Maritz, Gert S, Cock, Megan L, Louey, Samantha, Suzuki, Keiji, Harding, Richard·2004·Pediatric Research
DOI 10.1203/01.pdr.0000106314.99930.65
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Abstract

We have previously shown that fetal growth restriction (FGR) during late gestation in sheep affects lung development in the near-term fetus and at 8 wk after birth. In the present study, our aim was to determine the effects of FGR on the structure of the lungs at 2 y after birth; our hypothesis was that changes observed at 8 wk after birth would persist until maturity. FGR was induced in sheep by umbilicoplacental embolization, which was maintained from 120 d until delivery at term (approximately 147 d); birth weights of FGR lambs were 41% lower than in controls. At 2 y after birth, body and lung weights were not different, but there were 28% fewer alveoli and alveoli were significantly larger than in controls; hence there was a 10% reduction in the internal surface area relative to lung volume in FGR sheep compared with controls. The lungs of FGR sheep, compared with controls, had thicker interalveolar septa as a result of increased extracellular matrix deposition; the alveolar blood-air barrier was also thicker, largely because of an 82% increase in basement membrane thickness. These changes are qualitatively similar to those observed at 8 wk. Our data show that structural alterations in the lungs induced by FGR that were apparent at 8 wk were still evident at 2 y after birth, indicating that FGR may result in permanent changes in the structure of the lungs of the offspring and may affect respiratory health and lung aging later in life.

Overview

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Crossref · 10.1203/01.pdr.0000106314.99930.65

Cites

43 of 43 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 10

  1. Cock ML, 1997, Am J Physiol, 237, R1094
  2. Joyce BJ, 2003, Am J Physiol, 284, L643
  3. Scherle W, 1970, Mikroscopie, 26, 57
  4. Boros V, 1997, Am J Physiol, 272, L433
  5. Butler C, 1976, Am Rev Respir Dis, 114, 347
  6. Zhang HF, 1997, J Hirnforsch, 38, 81
  7. Snider GL, 1985, Am Rev Respir Dis, 132, 182
  8. 1962, Am Rev Respir Dis, 85, 762
  9. Ustiuzhaninova NV, 2002, Morfologiia, 121, 84
  10. Wilkes LK, 1992, Immunology, 75, 535

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Metadata

Authors
Maritz, G. S., Cock, M. L., Louey, S., Suzuki, K., & Harding, R.
Affiliations
  • University of the Western Cape (ZA)
  • Monash University (AU)
Corresponding author
Harding, Richard
ORCID
Venue
Pediatric Research
Publisher
Springer Science and Business Media LLC
Published
2004-02
Volume
55
Issue
2
Pages
287-295
ISSN
  • 0031-3998 (ISSN-L)
  • 1530-0447
DOI
10.1203/01.pdr.0000106314.99930.65
OpenAlex
W2080969687
Cited by
121
References
42
Citations by year
2026: 3 · 2025: 3 · 2024: 9 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 1 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 6 · 2015: 4 · 2014: 17 · 2013: 8 · 2012: 7
FWCI
2.99
Type
journal article
Language
en
Open access
closed
Locations
  • Pediatric Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Medical Research Council
  • National Health and Medical Research Council
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
Keywords
fetal growth restriction, lung development, alveolar structure, alveolar surface area, interalveolar septa, extracellular matrix deposition, basement membrane thickness, sheep model, lung aging, respiratory health
MeSH terms
Age Factors, Animals, DNA, Elastin, Female, Fetal Growth Retardation, Lung Volume Measurements, Microscopy, Electron, Organ Size, Oxygen, Pregnancy, Proteins, Pulmonary Alveoli, Pulmonary Gas Exchange, Sheep, Respiratory Mucosa

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