Relation of birth weight and childhood respiratory infection to adult lung function and death from chronic obstructive airways disease
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OBJECTIVE: To examine whether birth weight, infant weight, and childhood respiratory infection are associated with adult lung function and death from chronic obstructive airways disease. DESIGN: Follow up study of men born during 1911-30 whose birth weights, weights at 1 year, and childhood illnesses were recorded at the time by health visitors. SETTING: Hertfordshire, England. SUBJECTS: 5718 men born in the county during 1911-30 and a subgroup of 825 men born in the county during 1920-30 and still living there. MAIN OUTCOME MEASURES: Death from chronic obstructive airways disease, mean forced expiratory volume in one second (FEV1) and forced vital capacity (FVC), and respiratory symptoms. RESULTS: 55 men died of chronic obstructive airways disease. Death rates fell with increasing birth weight and weight at 1 year. Mean FEV1 at age 59 to 70 years, adjusted for height and age, rose by 0.06 litre (95% confidence interval 0.02 to 0.09) with each pound (450 g) increase in birth weight, independently of smoking habit and social class. Bronchitis or pneumonia in infancy was associated with a 0.17 litre (0.02 to 0.32) reduction in adult FEV1 and with an increased odds ratio of wheezing and persistent sputum production in adult life independently of birth weight, smoking habit, and social class. Whooping cough in infancy was associated with a 0.22 litre (0.02 to 0.42) reduction in adult FEV1. CONCLUSIONS: Lower birth weight was associated with worse adult lung function. Intrauterine influences which retard fetal weight gain may irrecoverably constrain the growth of the airways. Bronchitis, pneumonia, or whooping cough in infancy further reduced adult lung function. They also retarded infant weight gain. Consistent with this, death from chronic obstructive airways disease in adult life was associated with lower birth weight and weight at 1 year. Promoting lung growth in fetuses and infants and reducing the incidence of lower respiratory tract infection in infancy may reduce the incidence of chronic obstructive airways disease in the next generation.
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Large population-based studies from the early 1990s showed a 6-7% increased risk of reduced lung capacity after childhood pneumonia.
“These findings are consistent with large population-based studies of children in the early 1990s,46, 47, 48 which showed a 6–7% increased risk of reduced lung capacity after childhood pneumonia.”
From Global burden of childhood pneumonia and diarrhoea (2013) · cites this paper as [47]
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Cites
The natural history of chronic airflow obstruction.
Fletcher, C. M., & Peto, R. (1977) · BMJ · doi:10.1136/bmj.1.6077.1645 · Cited by 2,369 · see citing works
Statistical methods in cancer research. Vol. 1. The analysis of case-control studies
(1983) · Food and Chemical Toxicology · doi:10.1016/0278-6915(83)90281-8 · Cited by 1,726 · see citing works
Cellular Response in Rats during Malnutrition at Various Ages
Winick, M., & Noble, A. (1966) · Journal of Nutrition · doi:10.1093/jn/89.3.300 · Cited by 959 · see citing works
Statistical Methods in Cancer Research. Vol. 1: The Analysis of Case-Control Studies
Schmitz, P. I. M., Breslow, N. E., & Day, N. E. (1981) · Biometrics · doi:10.2307/2530192 · Cited by 625 · see citing works
Thurlbeck, W. M. (1982) · Thorax · doi:10.1136/thx.37.8.564 · Cited by 610 · see citing works
Pullan, C. R., & Hey, E. N. (1982) · BMJ · doi:10.1136/bmj.284.6330.1665 · Cited by 603 · see citing works
Peto, R., Speizer, F. E., Cochrane, A. L., Moore, F. M., Fletcher, C. M., Tinker, C. M., Higgins, I. T. T., Gray, R. G., Richards, S. M., Gilliland, J. J., et al. (1983) · American Review of Respiratory Disease · doi:10.1164/arrd.1983.128.3.491 · Cited by 415 · see citing works
Bucher, U., & REID, L. M. (1961) · Thorax · doi:10.1136/thx.16.3.207 · Cited by 269 · see citing works
Lung function in children of low birth weight.
Chan, K. N., Noble-Jamieson, C. M., Elliman, A., Bryan, E. M., & Silverman, M. (1989) · Archives of Disease in Childhood · doi:10.1136/adc.64.9.1284 · Cited by 213 · see citing works
Childhood respiratory infection and adult chronic bronchitis in England and Wales.
Barker, D. J., & Osmond, C. (1986) · BMJ · doi:10.1136/bmj.293.6557.1271 · Cited by 187 · see citing works
Self-citationPulmonary Function Abnormalities in Symptom-free Children After Bronchiolitis
Kattan, M., Keens, T. G., Lapierre, J.-G., et al. (1977) · PEDIATRICS · doi:10.1542/peds.59.5.683 · Cited by 184 · see citing works
Impact of infection on the growth of children from 0 to 2 years in an urban West African community
Rowland, M. G. M., Rowland, S. G. J. G., & Cole, T. J. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/47.1.134 · Cited by 161 · see citing works
Outcome for acute bronchitis, bronchiolitis, and pneumonia in infancy.
Mok, J. Y. Q., & Simpson, H. (1984) · Archives of Disease in Childhood · doi:10.1136/adc.59.4.306 · Cited by 116 · see citing works
Britten, N., Davies, J. M., & Colley, J. R. (1987) · BMJ · doi:10.1136/bmj.294.6583.1317 · Cited by 90 · see citing works
Evaluation of the turbine pocket spirometer.
Gunawardena, K. A., Houston, K., & Smith, A. (1987) · Thorax · doi:10.1136/thx.42.9.689 · Cited by 42 · see citing works
PASSIVE SMOKING AND LOW BIRTHWEIGHT
Chen, Y., Pederson, L. L., & Lefcoe, N. M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90304-8 · Cited by 34 · see citing works
Reid, D. D. (1969) · Proceedings of the Royal Society of Medicine · doi:10.1177/003591576906200401 · Cited by 33 · see citing works
RESPIRATORY MORBIDITY AND LUNG FUNCTION AFTER WHOOPING-COUGH
Johnston, I. D. A., Lambert, H. P., ANDERSON, H. R., & Patel, S. K. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90626-8 · Cited by 33 · see citing works
Long term respiratory sequelae of whooping cough in a nationally representative sample.
Britten, N., & Wadsworth, J. (1986) · BMJ · doi:10.1136/bmj.292.6518.441 · Cited by 31 · see citing works
INTERNATIONAL STUDIES IN CHRONIC RESPIRATORY DISEASE
Reid, D. D., & Fletcher, C. M. (1971) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a070816 · Cited by 30 · see citing works
Ciba Foundation Symposium 156 ‐ The Childhood Environment and Adult Disease
(2007) · Novartis Foundation symposium · doi:10.1002/9780470514047 · Cited by 24 · see citing works
Paternal smoking and fetal health
Davis, D. L. (1991) · The Lancet · doi:10.1016/0140-6736(91)90789-r · Cited by 18 · see citing works
Respiratory disease in infancy
McCall, M. G., & Acheson, E. D. (1968) · Journal of Chronic Diseases · doi:10.1016/0021-9681(68)90043-x · Cited by 17 · see citing works
Hosie, H., & Nimmo, W. S. (1988) · Anaesthesia · doi:10.1111/j.1365-2044.1988.tb05550.x · Cited by 14 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Swansea Research Unit of the Royal College of General Practitioners. Respiratory sequelae of whooping cough. BM7 1985;290:1937-40.
Cited by
Sorted by citations
Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983 · see citing works
Rabe, K. F., Hurd, S., Anzueto, A., Barnes, P. J., Buist, S. A., Calverley, P., Fukuchi, Y., Jenkins, C., Rodriguez-Roisin, R., van Weel, C., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200703-456so · Cited by 4,925 · see citing works
Vogelmeier, C. F., Criner, G. J., Martinez, F. J., Anzueto, A., Barnes, P. J., Bourbeau, J., Celli, B. R., Chen, R., Decramer, M., Fabbri, L. M., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201701-0218pp · Cited by 3,187 · see citing works
Barker, D. J. P., Hales, C. N., Fall, C. H. D., Osmond, C., Phipps, K., & Clark, P. M. S. (1993) · Diabetologia · doi:10.1007/bf00399095 · Cited by 2,468 · see citing works
Self-citationGlobal burden of childhood pneumonia and diarrhoea
Walker, C. L. F., Rudan, I., Liu, L., Nair, H., Theodoratou, E., Bhutta, Z. A., O'Brien, K. L., Campbell, H., & Black, R. E. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60222-6 · Cited by 2,356 · see citing works
The role of particle size in aerosolised pathogen transmission: a review
Gralton, J., Tovey, E., McLaws, M.-L., & Rawlinson, W. D. (2011) · Journal of Infection · doi:10.1016/j.jinf.2010.11.010 · Cited by 665 · see citing works
Health Disparities Beginning in Childhood: A Life-Course Perspective
Braveman, P., & Barclay, C. (2009) · Pediatrics · doi:10.1542/peds.2009-1100d · Cited by 653 · see citing works
A conceptual framework for the developmental origins of health and disease
Gluckman, P. D., Hanson, M. A., & Buklijas, T. (2010) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174409990171 · Cited by 592 · see citing works
Early life origins of chronic obstructive pulmonary disease
Svanes, C., Sunyer, J., Plana, E., Dharmage, S., Heinrich, J., Jarvis, D., de Marco, R., Norback, D., Raherison, C., Villani, S., et al. (2010) · Thorax · doi:10.1136/thx.2008.112136 · Cited by 466 · see citing works
Neonatal Morbidities of Fetal Growth Restriction: Pathophysiology and Impact
Malhotra, A., Allison, B. J., Castillo-Melendez, M., Jenkin, G., Polglase, G. R., & Miller, S. L. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00055 · Cited by 453 · see citing works
Early lung development: lifelong effect on respiratory health and disease
Stocks, J., Hislop, A., & Sonnappa, S. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70118-8 · Cited by 390 · see citing works
Fall, C. H., Barker, D. J., Osmond, C., Winter, P. D., Clark, P. M., & Hales, C. N. (1992) · BMJ · doi:10.1136/bmj.304.6830.801 · Cited by 362 · see citing works
Self-citationPneumonia in childhood and impaired lung function in adults: a longitudinal study
Chan, J. Y. C., Stern, D. A., Guerra, S., Wright, A. L., Morgan, W. J., & Martinez, F. D. (2015) · Pediatrics · doi:10.1542/peds.2014-3060 · Cited by 180 · see citing works
Long term sequelae from childhood pneumonia; systematic review and meta-analysis
Edmond, K., Scott, S., Korczak, V., Ward, C., Sanderson, C., Theodoratou, E., Clark, A., Griffiths, U., Rudan, I., & Campbell, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031239 · Cited by 175 · see citing works
Effect of pneumonia and whooping cough in childhood on adult lung function
Johnston, I. D. A., Strachan, D. P., & Anderson, H. R. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802263380904 · Cited by 169 · see citing works
Recent trends in COPD prevalence in Spain: a repeated cross-sectional survey 1997-2007
Soriano, J. B., Ancochea, J., Miravitlles, M., García-Río, F., Duran-Tauleria, E., Muñoz, L., Jiménez-Ruiz, C. A., Masa, J. F., Viejo, J. L., Villasante, C., et al. (2010) · European Respiratory Journal · doi:10.1183/09031936.00138409 · Cited by 168 · see citing works
Birth weight, childhood lower respiratory tract infection, and adult lung function
Shaheen, S. O., Sterne, J. A. C., Tucker, J. S., & Florey, C. D. V. (1998) · Thorax · doi:10.1136/thx.53.7.549 · Cited by 163 · see citing works
Self-citationPremature adrenarche: novel lessons from early onset androgen excess
Idkowiak, J., Lavery, G. G., Dhir, V., Barrett, T. G., Stewart, P. M., Krone, N., & Arlt, W. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0223 · Cited by 158 · see citing works
Maritz, G. S., Cock, M. L., Louey, S., Joyce, B. J., Albuquerque, C. A., & Harding, R. (2001) · Pediatric Pulmonology · doi:10.1002/ppul.1109 · Cited by 128 · see citing works
Fetal Growth Restriction Has Long-Term Effects on Postnatal Lung Structure in Sheep
Maritz, G. S., Cock, M. L., Louey, S., Suzuki, K., & Harding, R. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000106314.99930.65 · Cited by 121 · see citing works
Timing of nutrient restriction and programming of fetal adipose tissue development
Symonds, M. E., Pearce, S., Bispham, J., Gardner, D. S., & Stephenson, T. (2004) · Proceedings of the Nutrition Society · doi:10.1079/pns2004366 · Cited by 121 · see citing works
Lewis, S. A., & Britton, J. R. (1998) · Respiratory Medicine · doi:10.1016/s0954-6111(98)90427-9 · Cited by 82 · see citing works
Resource allocation in utero and health in later life
Barker, D. J. P., Lampl, M., Roseboom, T., & Winder, N. (2012) · Placenta · doi:10.1016/j.placenta.2012.06.009 · Cited by 81 · see citing works
Self-citation<i>In utero</i>cigarette smoke exposure impairs somatic and lung growth in BALB/c mice
Larcombe, A. N., Foong, R. E., Berry, L. J., Zosky, G. R., & Sly, P. D. (2011) · European Respiratory Journal · doi:10.1183/09031936.00156910 · Cited by 36 · see citing works
Associations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis
Frenzel, S., Bis, J. C., Gudmundsson, E. F., O’Donnell, A., Simino, J., Yaqub, A., Bartz, T. M., Brusselle, G. G. O., Bülow, R., DeCarli, C. S., et al. (2022) · Journal of Alzheimer's Disease · doi:10.3233/jad-220667 · Cited by 22 · see citing works
Validation of questionnaire-based case definitions for chronic obstructive pulmonary disease
Feinstein, L., Wilkerson, J., Salo, P. M., MacNell, N., Bridge, M. F., Fessler, M. B., Thorne, P. S., Mendy, A., Cohn, R. D., Curry, M. D., et al. (2020) · Epidemiology · doi:10.1097/ede.0000000000001176 · Cited by 13 · see citing works
- Authors
- Barker, D. J., Godfrey, K. M., Fall, C., Osmond, C., Winter, P. D., & Shaheen, S. O.
- Affiliations
- Southampton General Hospital (GB)
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1991-09-21
- Volume
- 303
- Issue
- 6804
- Pages
- 671-675
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W1967188184
- Cited by
- 889
- References
- 24
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 27 · 2023: 18 · 2022: 12 · 2021: 24 · 2020: 31 · 2019: 19 · 2018: 22 · 2017: 47 · 2016: 27 · 2015: 41 · 2014: 37 · 2013: 39 · 2012: 33
- FWCI
- 13.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Dunhill Medical Trust
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- birth weight, pediatric respiratory infection, adult lung function, chronic obstructive pulmonary disease, infant weight gain, bronchitis, pneumonia, pertussis, wheezing, forced expiratory volume, forced vital capacity, fetal growth restriction, airway growth
- MeSH terms
- Adult, Aged, Birth Weight, Child, Child, Preschool, England, Follow-Up Studies, Forced Expiratory Volume, Humans, Infant, Infant, Newborn, Lung, Lung Diseases, Obstructive, Male, Middle Aged, Respiratory Tract Infections, Vital Capacity
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