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Effects of Lyophilized Black Raspberries on Azoxymethane-Induced Colon Cancer and 8-Hydroxy-2′-Deoxyguanosine Levels in the Fischer 344 Rat
Abstract
This study examined the effects of lyophilized black raspberries (BRB) on azoxymethane (AOM)-induced aberrant crypt foci (ACF), colon tumors, and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in male Fischer 344 rats. AOM was injected (15 mg/kg body wt i.p.) once per week for 2 wk. At 24 h after the final injection, AOM-treated rats began consuming diets containing 0%, 2.5%, 5%, or 10% (wt/wt) BRB. Vehicle controls received 5% BRB or diet only. Rats were sacrificed after 9 and 33 wk of BRB feeding for ACF enumeration and tumor analysis. ACF multiplicity decreased 36%, 24%, and 21% (P < 0.01 for all groups) in the 2.5%, 5%, and 10% BRB groups, respectively, relative to the AOM-only group. Total tumor multiplicity declined 42%, 45%, and 71% (P < 0.05 for all groups). Although not significant, a decrease in tumor burden (28%, 42%, and 75%) was observed in all BRB groups. Adenocarcinoma multiplicity decreased 28%, 35%, and 80% (P < 0.01) in the same treatment groups. Urinary 8-OHdG levels were reduced by 73%, 81%, and 83% (P < 0.01 for all groups). These results indicate that BRB inhibit several measures of AOM-induced colon carcinogenesis and modulate an important marker of oxidative stress in the Fischer 344 rat.
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Cites
Antioxidant activity of plant extracts containing phenolic compounds
Kähkönen, M. P., Hopia, A. I., Vuorela, H. J., Rauha, J.-P., Pihlaja, K., Kujala, T. S., & Heinonen, M. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990146l · Cited by 3,854 · cited 1×
“Compared with other plant products, berries display marked antioxidant activity (30,31), a common feature of many food-based chemopreventives.”
BackgroundInsertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
Shibutani, S., Takeshita, M., & Grollman, A. P. (1991) · Nature · doi:10.1038/349431a0 · Cited by 2,224
Cited by
Anthocyanins: Natural Colorants with Health-Promoting Properties
He, J., & Giusti, M. M. (2010) · Annual Review of Food Science and Technology · doi:10.1146/annurev.food.080708.100754 · Cited by 1,637
Larrosa, M., Tomás-Barberán, F. A., & Espín, J. C. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.09.004 · Cited by 461
Cerdá, B., Tomás-Barberán, F. A., & Espín, J. C. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049144d · Cited by 450
Zhao, C., Giusti, M. M., Malik, M., Moyer, M. P., & Magnuson, B. A. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049517a · Cited by 302
Hager, A., Howard, L. R., Prior, R. L., & Brownmiller, C. (2008) · Journal of Food Science · doi:10.1111/j.1750-3841.2008.00855.x · Cited by 270
Metadata
- Authors
- Harris, G. K., Gupta, A., Nines, R. G., Kresty, L. A., Habib, S. G., Frankel, W. L., LaPerle, K., Gallaher, D. D., Schwartz, S. J., & Stoner, G. D.
- Venue
- Nutrition and Cancer
- Publisher
- Informa UK Limited
- Published
- 2001-05
- Volume
- 40
- Issue
- 2
- Pages
- 125-133
- ISSN
- 0163-5581 (ISSN-L)
- 1532-7914
- OpenAlex
- W2027243245
- Cited by
- 212
- References
- 2
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Harris, G. K., Gupta, A., Nines, R. G., Kresty, L. A., Habib, S. G., Frankel, W. L., LaPerle, K., Gallaher, D. D., Schwartz, S. J., & Stoner, G. D. (2001). Effects of Lyophilized Black Raspberries on Azoxymethane-Induced Colon Cancer and 8-Hydroxy-2′-Deoxyguanosine Levels in the Fischer 344 Rat. Nutrition and Cancer. https://doi.org/10.1207/s15327914nc402_8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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