Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content
Abstract
The present study was designed to investigate the protective efficiency of three garlic powders, obtained from bulbs grown in soils with different levels of sulfur fertilization, against DNA damage. Increasing fertilization of soil resulted in an increased alliin content of the powders. Garlic powders were administered to rats for 2 weeks (5% of the diet) and their antigenotoxic effects were examined in the liver and the colon using the comet assay. Consumption of the different garlic powders induced a 35-60% reduction in DNA damage induced by N-nitrosodimethylamine (NDMA) in rat liver. Increased alliin content of the garlic powder was associated strongly with a proportional decrease in NDMA induced DNA alteration. DNA damage induced by aflatoxin B1 in the liver or by 1,2-dimethylhydrazine in the colon were also decreased strongly by the three garlic powders but these decreases were not correlated to the alliin content of the garlic powders. Feeding garlic powders did not modify the genotoxic activity of the direct-acting carcinogen methylnitrosourea in the colon. Part of our results supports evidence that fertilization can have an impact on the protective capacity of garlic bulbs.
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Garlic powders inhibited DNA damage caused by N-nitrosodimethylamine in the liver when administered to rats by 35%, and this effect was due to the high concentration of alliin up to 60% in the samples.
“In addition, garlic powders inhibited the DNA damage caused by N-nitrosodimethylamine in the liver when administered to rats by 35% and this effect was due to the high concentration of alliin up to 60% in the samples [84].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [84]
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- Authors
- Singh, V., Belloir, C., Siess, M.-H., & Le Bon, A.-M.
- Affiliations
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- ORCID
- Belloir, Christine
- Venue
- Nutrition and Cancer
- Publisher
- Informa UK Limited
- Published
- 2006-07
- Volume
- 55
- Issue
- 2
- Pages
- 178-184
- ISSN
- 0163-5581 (ISSN-L)
- 1532-7914
- OpenAlex
- W1977717944
- Cited by
- 30
- References
- 38
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 4 · 2013: 4 · 2012: 3
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition and Cancer (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- garlic powder, alliin, DNA damage, carcinogen-induced DNA damage, N-nitrosodimethylamine, aflatoxin B1, 1,2-dimethylhydrazine, N-methyl-N-nitrosourea, liver, colon, antigenotoxicity
- MeSH terms
- Animals, Antineoplastic Agents, Colon, Colonic Neoplasms, Cysteine, Dimethylnitrosamine, DNA Damage, Dose-Response Relationship, Drug, Fertilizers, Garlic, Liver, Liver Neoplasms, Experimental, Male, Nitrosamines, Precancerous Conditions, Specific Pathogen-Free Organisms, Aflatoxin B1, Rats, Wistar, Chemoprevention, 1,2-Dimethylhydrazine, Comet Assay, Rats
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