Vesicular monoamine transporter 2: Role as a novel target for drug development
Open accessAbstract
In the central nervous system, vesicular monoamine transporter 2 (VMAT2) is the only transporter that moves cytoplasmic dopamine (DA) into synaptic vesicles for storage and subsequent exocytotic release. Pharmacologically enhancing DA sequestration by VMAT2, and thus preventing the oxidation of DA in the cytoplasm, may be a strategy for treating diseases such as Parkinson's disease. VMAT2 may also be a novel target for the development of treatments for psychostimulant abuse. This review summarizes the possible role of VMAT2 as a therapeutic target, VMAT2 ligands reported in the literature, and the structure-activity relationship of these ligands, including tetrabenazine analogs, ketanserin analogs, lobeline analogs, and 3-amine-2-phenylpropene analogs. The molecular structure of VMAT2 and its relevance to ligand binding are briefly discussed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The mechanism of action of tetrabenazine is believed to involve the early metabolic degradation of monoamines, in particular DA.
“Its mechanism of action is believed to involve the early metabolic degradation of monoamines, in particular DA [646].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [646]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Part of this paper’s reference list could not be split into single entries.
A psychomotor stimulant theory of addiction.
Wise, R. A., & Bozarth, M. A. (1987) · Psychological Review · doi:10.1037/0033-295x.94.4.469 · Cited by 2,747 · see citing works
Leysen, J. E., Niemegeers, C. J. E., Nueten, J. M. V., & Laduron, P. M. (1982) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)14623-3 · Cited by 1,071 · see citing works
Drug Facts and Comparisons 1991.
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-823_1 · Cited by 776 · see citing works
Sulzer, D., Chen, T., Lau, Y., Kristensen, H., Rayport, S., & Ewing, A. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-04102.1995 · Cited by 688 · see citing works
Neural Mechanisms of Drug Reinforcementa
Koob, G. F. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb25966.x · Cited by 607 · see citing works
A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter
Liu, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90425-c · Cited by 589 · see citing works
Jenner, P. G., Dexter, D. T., Sian, J., Schapira, A. H. V., & MARSDEN, C. D. (1992) · Annals of Neurology · doi:10.1002/ana.410320714 · Cited by 545 · see citing works
Expression cloning of a reserpine-sensitive vesicular monoamine transporter.
Erickson, J. D., Eiden, L. E., & Hoffman, B. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10993 · Cited by 488 · see citing works
Erickson, J. D., Schäfer, M., Bonner, T. I., Eiden, L. E., & Weihe, E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.5166 · Cited by 480 · see citing works
Tetrabenazine as antichorea therapy in Huntington disease: A randomized controlled trial
Huntington Study Group (2006) · Neurology · doi:10.1212/01.wnl.0000198586.85250.13 · Cited by 471 · see citing works
Takahashi, N., Miner, L. L., Sora, I., Ujike, H., Revay, R. S., Kostić, V., Jackson-Lewis, V. R., Przedborski, S., & Uhl, G. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9938 · Cited by 429 · see citing works
Sulzer, D., & Rayport, S. (1990) · Neuron · doi:10.1016/0896-6273(90)90339-h · Cited by 389 · see citing works
Wang, Y.-M., Gainetdinov, R. R., Fumagalli, F., Xu, F., Jones, S. R., Bock, C. B., Miller, G. W., Wightman, R. M., & Caron, M. G. (1997) · Neuron · doi:10.1016/s0896-6273(00)80419-5 · Cited by 376 · see citing works
Long-term effects of tetrabenazine in hyperkinetic movement disorders
Jankovic, J. J., & Beach, J. (1997) · Neurology · doi:10.1212/wnl.48.2.358 · Cited by 355 · see citing works
Differential expression of two vesicular monoamine transporters
Peter, D., Liu, Y., Sternini, C., GIORGIO, R. D., Brecha, N. C., & Edwards, R. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-09-06179.1995 · Cited by 333 · see citing works
Johnson, R. G. (1988) · Physiological Reviews · doi:10.1152/physrev.1988.68.1.232 · Cited by 323 · see citing works
Tetrabenazine as antichorea therapy in Huntington disease: A randomized controlled trial
Savani, A. A., & Login, I. S. (2007) · Neurology · doi:10.1212/01.wnl.0000259143.52138.5c · Cited by 298 · see citing works
Snyder, S. H., & D’Amato, R. J. (1986) · Neurology · doi:10.1212/wnl.36.2.250 · Cited by 295 · see citing works
THE ROLE OF VESICULAR TRANSPORT PROTEINS IN SYNAPTIC TRANSMISSION AND NEURAL DEGENERATION
Liu, Y., & Edwards, R. H. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.125 · Cited by 295 · see citing works
Sulzer, D. L., Maidment, N. T., & Rayport, S. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03181.x · Cited by 292 · see citing works
Neurotransmitter transporters as molecular targets for addictive drugs
Amara, S. G., & Sonders, M. S. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00068-4 · Cited by 288 · see citing works
New insights into the cause of Parkinson's disease
Jenner, P., Schapira, A. H. V., & MARSDEN, C. D. (1992) · Neurology · doi:10.1212/wnl.42.12.2241 · Cited by 272 · see citing works
Fumagalli, F., Gainetdinov, R. R., Wang, Y., Valenzano, K. J., Miller, G. W., & Caron, M. G. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02424.1999 · Cited by 241 · see citing works
Weihe, E., Schäfer, M. K.-H., Erickson, J. D., & Eiden, L. E. (1994) · Journal of Molecular Neuroscience · doi:10.1007/bf02736730 · Cited by 230 · see citing works
Peter, D., Jimenez, J., Liu, Y., Kim, M., & Edwards, R. H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37272-1 · Cited by 227 · see citing works
A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse
Dwoskin, L. P., & Crooks, P. A. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00899-1 · Cited by 219 · see citing works
Self-citationNicotinic receptor agonists exhibit anxiolytic-like effects on the elevated plus-maze test
Brioni, J. D., O'Neill, A. B., Kim, D. J. B., & Decker, M. W. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90498-7 · Cited by 216 · see citing works
The etiology of Parkinson's disease with emphasis on the MPTP story
Langston, J. W. (1996) · Neurology · doi:10.1212/wnl.47.6_suppl_3.153s · Cited by 180 · see citing works
Increased MPTP Neurotoxicity in Vesicular Monoamine Transporter 2 Heterozygote Knockout Mice
Gainetdinov, R. R., Fumagalli, F., Wang, Y., Jones, S. R., Levey, A. I., Miller, G. W., & Caron, M. G. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70051973.x · Cited by 178 · see citing works
Benzoquinolizine Derivatives: a New Class of Monamine Decreasing Drugs With Psychotropic Action
Pletscher, A., BROSSI, A., & GEY, K. F. (1962) · International review of neurobiology · doi:10.1016/s0074-7742(08)60024-0 · Cited by 168 · see citing works
Henry, J., & Scherman, D. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90082-8 · Cited by 165 · see citing works
Methamphetamine Rapidly Decreases Vesicular Dopamine Uptake
Brown, J. M., Hanson, G. R., & Fleckenstein, A. E. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0742221.x · Cited by 158 · see citing works
Tetrabenazine in the treatment of hyperkinetic movement disorders
Kenney, C., & Jankovic, J. J. (2006) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.6.1.7 · Cited by 158 · see citing works
Functional Identification and Molecular Cloning of a Human Brain Vesicle Monoamine Transporter
Erickson, J. D., & Eiden, L. E. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb07476.x · Cited by 158 · see citing works
Parkinsons Disease - Redox Mechanisms
Adams, J. D., Jr., Chang, M., & Klaidman, L. K. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013372995 · Cited by 139 · see citing works
Scherman, D., & Henry, J. (1984) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)15021-9 · Cited by 136 · see citing works
Brown, J. M., Hanson, G. R., & Fleckenstein, A. E. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38814-7 · Cited by 135 · see citing works
Teng, L., Crooks, P. A., Sonsalla, P. K., & Dwoskin, L. P. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36537-1 · Cited by 133 · see citing works
Self-citationHall, E. D., Andrus, P. K., Oostveen, J. A., Althaus, J. S., & Voigtlander, P. F. V. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00968-7 · Cited by 133 · see citing works
Tetrabenazine in the treatment of hyperkinetic movement disorders.
Jankovic, J. J. (1983) · PubMed · Cited by 129 · see citing works
Scherman, D., Jaudon, P., & Henry, J. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.2.584 · Cited by 126 · see citing works
The binding of L-[3H]nicotine to a single class of high affinity sites in rat brain membranes.
Lippiello, P. M., & Fernandes, K. G. (1986) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10280-0 · Cited by 123 · see citing works
Mooslehner, K. A., Chan, P. M., Xu, W., Liu, L., Smadja, C., Humby, T., Allen, N. D., Wilkinson, L. S., & Emson, P. C. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.16.5321-5331.2001 · Cited by 118 · see citing works
Role of monoamine transporters in mediating psychostimulant effects
Riddle, E. L., Fleckenstein, A. E., & Hanson, G. R. (2005) · The AAPS Journal · doi:10.1208/aapsj070481 · Cited by 117 · see citing works
Dissociations between the locomotor stimulant and depressant effects of nicotinic agonists in rats
Stolerman, I. P., Garcha, H. S., & Mirza, N. R. (1995) · Psychopharmacology · doi:10.1007/bf02246215 · Cited by 113 · see citing works
Monoamine Oxidase and Mitochondrial Respiration
Cohen, G., & Kesler, N. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0732310.x · Cited by 113 · see citing works
Further studies on nicotine-induced conditioned place preference in the rat
Fudala, P. J., & Iwamoto, E. T. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90083-3 · Cited by 112 · see citing works
Lobeline Attenuates d-Methamphetamine Self-Administration in Rats
Harrod, S. B., Dwoskin, L. P., Crooks, P. A., Klebaur, J. E., & Bardo, M. T. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29365-4 · Cited by 111 · see citing works
Self-citationActivation and inhibition of the human α7 nicotinic acetylcholine receptor by agonists
Briggs, C. A., & McKenna, D. G. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00110-5 · Cited by 108 · see citing works
Glatt, C. E., Wahner, A. D., White, D. J., Ruiz‐Linares, A., & Ritz, B. R. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi445 · Cited by 108 · see citing works
Teng, L., Crooks, P. A., & Dwoskin, L. P. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71010258.x · Cited by 108 · see citing works
Self-citationEffects of lobeline, a nicotinic receptor agonist, on learning and memory
Decker, M. W., Majchrzak, M. J., & Arnerić, S. P. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90508-q · Cited by 107 · see citing works
Sandoval, V., Riddle, E. L., Hanson, G. R., & Fleckenstein, A. E. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.045005 · Cited by 104 · see citing works
Borght, T. M. V., Sima, A. A. F., Kilbourn, M. R., Desmond, T. J., Kuhl, D. E., & Frey, K. A. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00167-h · Cited by 99 · see citing works
Staal, R. G. W., & Sonsalla, P. K. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39240-7 · Cited by 98 · see citing works
Binding of α-dihydrotetrabenazine to the vesicular monoamine transporter is stereospecific
Kilbourn, M. R., Lee, L., Borght, T. V., Jewett, D. M., & Frey, K. A. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00162-e · Cited by 98 · see citing works
Pharmacology of Lobeline, A Nicotinic Receptor Ligand
Damaj, M. I., Patrick, G., Creasy, K. R., & Martin, B. R. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36807-7 · Cited by 96 · see citing works
Barlow, R. B., & Johnson, O. W. (1989) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1989.tb14608.x · Cited by 94 · see citing works
Impact of psychostimulants on vesicular monoamine transporter function
Fleckenstein, A. E., & Hanson, G. R. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.077 · Cited by 93 · see citing works
Koeppe, R. A., Frey, K. A., Kume, A., Albin, R. L., Kilbourn, M. R., & Kuhl, D. E. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199709000-00001 · Cited by 90 · see citing works
Merickel, A., Kaback, H. R., & Edwards, R. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5403 · Cited by 88 · see citing works
Daniels, A. J., & Reinhard, J. F. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60674-x · Cited by 87 · see citing works
Lobeline Inhibits the Neurochemical and Behavioral Effects of Amphetamine
Miller, D. K., Crooks, P. A., Teng, L., Witkin, J. M., Munzar, P., Goldberg, S. R., Acri, J. B., & Dwoskin, L. P. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38847-0 · Cited by 86 · see citing works
Self-citationKetanserin binds to the monoamine transporter of chromaffin granules and of synaptic vesicles.
Darchen, F., Scherman, D., Laduron, P. M., & Henry, J. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13392-0 · Cited by 86 · see citing works
Darchen, F., Scherman, D., & Henry, J. P. (1989) · Biochemistry · doi:10.1021/bi00430a040 · Cited by 85 · see citing works
[3H]Dihydrotetrabenazine, a New In Vitro Monoaminergic Probe for Human Brain
Scherman, D., Raisman‐Vozari, R., Ploska, A., & Agid, Y. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb10583.x · Cited by 85 · see citing works
Identification of Residues Involved in Substrate Recognition by a Vesicular Monoamine Transporter
Merickel, A., Rosandich, P., Peter, D., & Edwards, R. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.43.25798 · Cited by 81 · see citing works
A simple synthesis of [11C]Dihydrotetrabenazine (DTBZ)
Jewett, D. M., Kilbourn, M. R., & Lee, L. C. (1997) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(96)00213-2 · Cited by 79 · see citing works
Tetrabenazine, an amine-depleting drug, also blocks dopamine receptors in rat brain.
Reches, A., Burke, R. E., Kuhn, C. M., Hassan, M. N., Jackson, V., & Fahn, S. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)33621-9 · Cited by 75 · see citing works
Reinforcing Effects of Nicotinic Compounds Intravenous Self-administration in Drug-Naive Mice
Rasmussen, T. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00003-3 · Cited by 73 · see citing works
Miller, D. K., Crooks, P. A., Zheng, G., Grinevich, V. P., Norrholm, S. D., & Dwoskin, L. P. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.068098 · Cited by 73 · see citing works
Self-citationMiller, D. K., Crooks, P. A., & Dwoskin, L. P. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00140-4 · Cited by 70 · see citing works
Self-citationSelective MPP+ uptake into synaptic dopamine vesicles: possible involvement in MPTP neurotoxicity
Zompo, M. D., Piccardi, M. P., Ruiu, S., Quartu, M., GESSA, G. L., & Vaccari, A. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb13584.x · Cited by 69 · see citing works
Syntheseversuche in der Emetin‐Reihe. 1. Mitteilung. 2‐Oxo‐hydrobenzo[a]chinolizine
BROSSI, A., Lindlar, H., Walter, M. G., & Schnider, O. (1958) · Helvetica Chimica Acta · doi:10.1002/hlca.660410117 · Cited by 68 · see citing works
Kilbourn, M. R., DaSilva, J. N., Frey, K. A., Koeppe, R. A., & Kuhl, D. E. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03521.x · Cited by 68 · see citing works
Tanaka, M., Yamazaki, H., Hakusui, H., Nakamichi, N., & Sekino, H. (1997) · Chirality · doi:10.1002/(sici)1520-636x(1997)9:1 · Cited by 67 · see citing works
Brain nicotinic acetylcholine receptors. Biochemical characterization by neosurugatoxin.
Yamada, S., Isogai, M., Kagawa, Y., Takayanagi, N., Hayashi, E. Y., Tsuji, K., & Kosuge, T. (1985) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13496-2 · Cited by 65 · see citing works
The comparative binding characteristics of nicotinic ligands and their pharmacology
Sloan, J. W., Martin, W. R., Bostwick, M., Hook, R. H., & Wala, E. P. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90454-6 · Cited by 64 · see citing works
Zheng, G., Dwoskin, L. P., Deaciuc, A. G., Norrholm, S. D., & Crooks, P. A. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm0501228 · Cited by 63 · see citing works
Self-citationLeysen, J. E., Eens, A., Gommeren, W., Gompel, P. V., Wynants, J., & Janssen, P. A. J. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24276-8 · Cited by 63 · see citing works
Sethy, V. H., Wu, H., Oostveen, J. A., & Hall, E. D. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00075-9 · Cited by 61 · see citing works
Speciale, S. G., Liang, C., Sonsalla, P. K., Edwards, R. H., & German, D. C. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00570-8 · Cited by 59 · see citing works
In vivo imaging of the brain vesicular monoamine transporter.
Borght, T. M. V., Kilbourn, M. R., Koeppe, R. A., DaSilva, J. N., Carey, J. E., Kuhl, D. E., & Frey, K. A. (1995) · PubMed · Cited by 57 · see citing works
Metabolic studies of tetrabenazine, a psychotropic drug in animals and man
Schwartz, D. E., Bruderer, H., Rieder, J., & BROSSI, A. (1966) · Biochemical Pharmacology · doi:10.1016/0006-2952(66)90031-1 · Cited by 56 · see citing works
Lobeline attenuates locomotor stimulation induced by repeated nicotine administration in rats
Miller, D. K., Harrod, S. B., Green, T. A., Wong, M.-Y., Bardo, M. T., & Dwoskin, L. P. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00996-6 · Cited by 54 · see citing works
Self-citationLobeline does not serve as a reinforcer in rats
Harrod, S. B., Dwoskin, L. P., Green, T. A., Gehrke, B. J., & Bardo, M. T. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1289-6 · Cited by 51 · see citing works
Self-citationGallardo, K. A., & Leslie, F. M. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70020663.x · Cited by 51 · see citing works
In vivo specific binding of [3H]-1-nicotine in the mouse brain
Broussolle, E. P., Wong, D. F., Fanelli, R. J., & London, E. D. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90340-8 · Cited by 47 · see citing works
Peter, D., Vu, T., & Edwards, R. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.6.2979 · Cited by 47 · see citing works
Pletscher, A. (1977) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1977.tb08395.x · Cited by 47 · see citing works
Masuo, Y., Pélaprat, D., Scherman, D., & Rostène, W. H. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90426-a · Cited by 46 · see citing works
Finn, J. P., & Edwards, R. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.26.16301 · Cited by 43 · see citing works
German, D. C., Liang, C., Manaye, K. F., Lane, K. B., & Sonsalla, P. K. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00385-7 · Cited by 41 · see citing works
Ontogeny of vesicular monoamine transporter mRNAs VMAT1 and VMAT2
Hansson, S. R., Mezey, É., & Hoffman, B. J. (1998) · Developmental Brain Research · doi:10.1016/s0165-3806(98)00103-5 · Cited by 40 · see citing works
Truong, J. G., Rau, K. S., Hanson, G. R., & Fleckenstein, A. E. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)02080-6 · Cited by 39 · see citing works
Lobelane analogues as novel ligands for the vesicular monoamine transporter-2
Zheng, G., Dwoskin, L. P., Deaciuc, A. G., Zhu, J., Jones, M. D., & Crooks, P. A. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2005.04.013 · Cited by 38 · see citing works
Self-citationDaSilva, J. N., Kilbourn, M. R., & Domino, E. F. (1993) · Synapse · doi:10.1002/syn.890140205 · Cited by 38 · see citing works
Thiriot, D. S., & Ruoho, A. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103947200 · Cited by 37 · see citing works
DaSilva, J. N., Carey, J. E., Sherman, P. S., Pisani, T., & Kilbourn, M. R. (1994) · Nuclear Medicine and Biology · doi:10.1016/0969-8051(94)90003-5 · Cited by 37 · see citing works
Darchen, F., Scherman, D., Desnos, C., & Henry, J. (1988) · Biochemical Pharmacology · doi:10.1016/0006-2952(88)90621-1 · Cited by 33 · see citing works
Moriyama, Y., Amakatsu, K., & Futai, M. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1422 · Cited by 32 · see citing works
Sievert, M. K., & Ruoho, A. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.26049 · Cited by 32 · see citing works
Zucker, M., Weizman, A., & Rehavi, M. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01301-7 · Cited by 31 · see citing works
Psychostimulants and Vesicle Trafficking: A Novel Mechanism and Therapeutic Implications
Hanson, G. R., Sandoval, V., Riddle, E. L., & Fleckenstein, A. E. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1316.019 · Cited by 31 · see citing works
Isambert, M. F., Gasnier, B., Laduron, P. M., & Henry, J. P. (1989) · Biochemistry · doi:10.1021/bi00431a044 · Cited by 31 · see citing works
Pettibone, D. J., Pflueger, A. B., & Totaro, J. A. (1984) · European Journal of Pharmacology · doi:10.1016/0014-2999(84)90563-6 · Cited by 30 · see citing works
DaSilva, J. N., Kilbourn, M. R., & Mangner, T. J. (1993) · Applied Radiation and Isotopes · doi:10.1016/0969-8043(93)90103-h · Cited by 30 · see citing works
Hydrophobicity of the tetrabenazine-binding site of the chromaffin granule monoamine transporter.
Scherman, D., Gasnier, B., Jaudon, P., & Henry, J. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13112-x · Cited by 30 · see citing works
Synthesis of [11C]tetrabenazine, a vesicular monoamine uptake inhibitor, for PET imaging studies
DaSilva, J. N., Kilbourn, M. R., & Mangner, T. J. (1993) · Applied Radiation and Isotopes · doi:10.1016/0969-8043(93)90130-3 · Cited by 29 · see citing works
Apomorphine increases vesicular monoamine transporter-2 function: implications for neurodegeneration
Truong, J. G., Hanson, G. R., & Fleckenstein, A. E. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.03.060 · Cited by 29 · see citing works
Thiriot, D. S., Sievert, M. K., & Ruoho, A. E. (2002) · Biochemistry · doi:10.1021/bi015779j · Cited by 28 · see citing works
Lee, L. C., Borght, T. V., Sherman, P. S., Frey, K. A., & Kilbourn, M. R. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm950117b · Cited by 27 · see citing works
Kariya, S., Takahashi, N., Hirano, M., & Ueno, S. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:27:3:277 · Cited by 25 · see citing works
Vesicular Neurotransmitter Transporters*: Pharmacology, Biochemistry, and Molecular Analysis
Yelin, R., & Schuldiner, S. (2003) · Humana Press eBooks · doi:10.1385/1-59259-158-2:313 · Cited by 21 · see citing works
Syntheseversuche in der Emetin‐Reihe. 3. Mitteilung. 2‐Hydroxy‐hydrobenzo[a]chinolizine
BROSSI, A., Chopard‐dit‐Jean, L. H., & Schnider, O. (1958) · Helvetica Chimica Acta · doi:10.1002/hlca.19580410634 · Cited by 20 · see citing works
Binding of 125I‐iodovinyltetrabenazine to CNS vesicular monoamine transport sites
Kung, M., Canney, D. J., Frederick, D., Zhuang, Z., Billings, J. J., & Kung, H. F. (1994) · Synapse · doi:10.1002/syn.890180308 · Cited by 18 · see citing works
Perera, R. P., Wimalasena, D. S., & Wimalasena, K. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm030004p · Cited by 17 · see citing works
Zheng, G., Dwoskin, L. P., Deaciuc, A. G., & Crooks, P. A. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.07.032 · Cited by 16 · see citing works
Self-citationScherman, D., Darchen, F., Desnos, C., & Henry, J. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90317-2 · Cited by 15 · see citing works
Damaj, M. I., Glassco, W., Marks, M. J., Slobe, B. S., James, J. R., May, E. L., Rosecrans, J. A., Collins, A. C., & Martin, B. R. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36922-8 · Cited by 14 · see citing works
Canney, D. J., Guo, Y., Kung, M., & Kung, H. F. (1993) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.2580330413 · Cited by 13 · see citing works
Canney, D. J., Kung, M., & Kung, H. F. (1995) · Nuclear Medicine and Biology · doi:10.1016/0969-8051(94)00118-4 · Cited by 13 · see citing works
A benzo[a]quinolizine derivative with a neuroleptic-like action on cerebral monoamine turnover.
Saner, A., & Pletscher, A. (1977) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)31082-7 · Cited by 12 · see citing works
A series of hexahydro[1,4]oxazino[3,4-a]isoquinolines as potential neuroleptics
Clarke, F. H., Hill, R. T., Koo, J., Lopano, R. M., Maseda, M. A., Smith, M. E., Soled, S., Veh, G. V., & Vlattas, I. (1978) · Journal of Medicinal Chemistry · doi:10.1021/jm00206a013 · Cited by 11 · see citing works
Kilbourn, M. R., Sherman, P. S., & Abbott, L. C. (1995) · Nuclear Medicine and Biology · doi:10.1016/0969-8051(95)00005-i · Cited by 10 · see citing works
Banerjee, S., & Abood, L. G. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90454-1 · Cited by 9 · see citing works
2-Thio-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizines
Harnden, M. R., & Short, J. H. (1967) · Journal of Medicinal Chemistry · doi:10.1021/jm00318a051 · Cited by 7 · see citing works
A Role for the Vesicular Monoamine Transporter (VMAT2) in Parkinson’s Disease
German, D. C., & Sonsalla, P. K. (2002) · Advances in behavioral biology · doi:10.1007/978-1-4615-0179-4_13 · Cited by 6 · see citing works
Ketanserin as a Ligand of the Vesicular Monoamine Transporter
Henry, J., Gasnier, B., Isambert, M. F., Darchen, F., & Scherman, D. (1991) · Elsevier eBooks · doi:10.1016/b978-0-08-041165-1.50055-7 · Cited by 5 · see citing works
Synthesis and biological activity of iodinated and photosensitive derivatives of tetrabenazine
Aranda, G., Beaucourt, J. P., Ponchant, M., Isambert, M. F., & Henry, J. (1990) · European Journal of Medicinal Chemistry · doi:10.1016/0223-5234(90)90121-i · Cited by 5 · see citing works
Octahydrophenanthrene Analogs of Tetrabenazine
Fahrenholtz, K. E., Capomaggi, A. S., Lurie, M., Goldberg, M. W., & Kierstead, R. W. (1966) · Journal of Medicinal Chemistry · doi:10.1021/jm00321a009 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 11
- Scherman D , Henry JP . Reserpine binding to bovine chromaffi n granule membranes. Mol Pharmacol . 1984 ; 25 : 113 -122 .
- Snyder SH , D ' Amato RJ . MPTP: a neurotoxin relevant to the pathophysiology of Parkinson ' s disease. Neurology . 1986 ; 36 : 250 -258 .
- Adams JD, Jr , Chang ML , Klaidman L . Parkinson ' s disease -redox mechanisms. Curr Med Chem . 2001 ; 8 : 809 -814 .
- Brossi A , Lindlar H , Walter M , Schnider O . Synthesis in the emetine series, I: 2-oxohydrobenzo[a]quinolizines. Helv Chim Acta . 1958 ; 41 : 1793 -1806 .
- Huntington Study Group. Tetrabenazine as antichorea therapy in Huntington disease. Neurology . 2006 ; 66 : 366 -372 .
- Kilbourn MR . PET radioligands for vesicular neurotransmitter transporters. Med Chem Res . 1994 ; 5 : 113 -126 .
- Kilbourn MR , Lee LC , Heeg MJ , Jewett DM . Absolute confi guration of (+)-dihydrotetrabenazine, an active metabolite of tetrabenazine. Chirality . 1997 ; 9 : 59 -62 .
- Kilbourn MR , Lee LC , Jewett DM , Vander Borght TM , Koeppe RA , Frey KA . In vitro and in vivo binding of a -dihydrotetrabenazine to the vesicular monoamine transporter is stereospecifi c. J Cereb Blood Flow Metab . 1995 ; 15 : S650 .
- Clarke I, Turtle R, Johnston G, inventors. Cambridge Laboratories Limited, UK, assignee. Preparation of dihydrotetrabenazines with affi nity for monoamine transporters for use in pharmaceutical compositions for the treatment of hyperkinetic disorders. WO 2 005 077 946. February 11, 2005 .
- Tridgett R , Clarke I, Turtle R, Johnston G , inventors. Cambridge Laboratories Limited, UK, assignee. Preparation of dihydrotetrabenazine isomers for the treatment of hyperkinetic movement disorders. GB 2 410 947 . February 11 , 2004.
- 4-a]isoquinolines as potential neuroleptics. J Med Chem . 1978 ; 21 : 785 -791 .
Cited by
Sorted by citations
Natural products: An evolving role in future drug discovery
Mishra, B. B., & Tiwari, V. K. (2011) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2011.07.057 · Cited by 866 · see citing works
Samuels, E., & Szabadi, E. (2008) · Current Neuropharmacology · doi:10.2174/157015908785777193 · Cited by 454 · see citing works
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Parkinson’s Disease: Pathogenesis and Clinical Aspects
(2018) · Codon Publications eBooks · doi:10.15586/codonpublications.parkinsonsdisease.2018 · Cited by 295 · see citing works
Vesicular monoamine transporters: Structure‐function, pharmacology, and medicinal chemistry
Wimalasena, K. (2010) · Medicinal Research Reviews · doi:10.1002/med.20187 · Cited by 199 · see citing works
Szabadi, E. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01069 · Cited by 145 · see citing works
Current and Possible Future Therapeutic Options for Huntington’s Disease
Ferguson, M. W., Kennedy, C. J., Palpagama, T. H., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2022) · Journal of Central Nervous System Disease · doi:10.1177/11795735221092517 · Cited by 126 · see citing works
Brain dopamine and serotonin differ in regulation and its consequences
Hashemi, P., Dankoski, E. C., Lama, R., Wood, K. M., Takmakov, P. A., & Wightman, R. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201547109 · Cited by 111 · see citing works
Fleckenstein, A. E., Volz, T. J., & Hanson, G. R. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.002 · Cited by 100 · see citing works
Tourette??s Syndrome and Role??of??Tetrabenazine
Porta, M., Sassi, M., Cavallazzi, M., Fornari, M., Brambilla, A., & Servello, D. (2008) · Clinical Drug Investigation · doi:10.2165/00044011-200828070-00006 · Cited by 93 · see citing works
Vergo, S. B., Johansen, J. L., Leist, M., & Lotharius, J. (2007) · Brain Research · doi:10.1016/j.brainres.2007.09.028 · Cited by 89 · see citing works
Kuperstein, F., Eilam, R., & Yavin, E. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05418.x · Cited by 81 · see citing works
Tetrabenazine: Spotlight on Drug Review
Kaur, N., Kumar, P., Jamwal, S., Deshmukh, R. R., & Gauttam, V. K. (2016) · Annals of Neurosciences · doi:10.1159/000449184 · Cited by 79 · see citing works
Lee, A. K., Mojtahed-Jaberi, M., Kyriakou, T., Aldecoa-Otalora, E., Arno, M. J., Marshall, N. J., Brain, S. D., & O’Dell, S. D. (2009) · Nutrition · doi:10.1016/j.nut.2009.05.007 · Cited by 78 · see citing works
Monoamine oxidases in development
Wang, C. C., Billett, E. E., Borchert, A., Kühn, H., & Ufer, C. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1065-7 · Cited by 77 · see citing works
The vesicular monoamine transporter 2: An underexplored pharmacological target
Bernstein, A. I., Stout, K. A., & Miller, G. W. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2013.12.003 · Cited by 74 · see citing works
Hu, G., Henke, A., Karpowicz, R. J., Sonders, M. S., Farrimond, F., Edwards, R. H., Sulzer, D. L., & Sameš, D. (2013) · ACS Chemical Biology · doi:10.1021/cb400259n · Cited by 69 · see citing works
Pardo, M., López‐Cruz, L., Miguel, N. S., Salamone, J. D., & Correa, M. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3872-7 · Cited by 66 · see citing works
Transport and inhibition mechanisms of human VMAT2
Wu, D., Chen, Q., Yu, Z., Huang, B., Zhao, J., Wang, Y., Su, J., Zhou, F., Yan, R., Li, N., et al. (2023) · Nature · doi:10.1038/s41586-023-06926-4 · Cited by 62 · see citing works
Wang, G., Pan, J., Tan, Y., Sun, X., Zhang, Y., Zhou, H., Ren, R., Wang, X., & Chen, S. (2008) · Neuropeptides · doi:10.1016/j.npep.2008.03.002 · Cited by 57 · see citing works
Clinical Pharmacology of Dopamine-Modulating Agents in Tourette’s Syndrome
Mogwitz, S., Buse, J., Ehrlich, S., & Roessner, V. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-411546-0.00010-x · Cited by 56 · see citing works
Tamboli, A. M., Rub, R. A., Ghosh, P., & Bodhankar, S. (2012) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(12)60092-6 · Cited by 55 · see citing works
Hayden, M. R., Leavitt, B. R., Yasothan, U., & Kirkpatrick, P. J. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2784 · Cited by 53 · see citing works
Using the affective bias test to predict drug‐induced negative affect: implications for drug safety
Stuart, S. A., Wood, C. M., & Robinson, E. S. J. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13972 · Cited by 52 · see citing works
Mignini, F., Tomassoni, D., Traini, E., & Amenta, F. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.09.018 · Cited by 46 · see citing works
Stefanović, B., Spasojević, N., Jovanović, P., Jasnic, N. I., Djordjevic, J. D., & Dronjak, S. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.07.005 · Cited by 46 · see citing works
In Vitro and In Vivo Characterization of the Alkaloid Nuciferine
Farrell, M. S., McCorvy, J. D., Huang, X., Urban, D. J., White, K. L., Giguère, P. M., Doak, A. K., Bernstein, A. I., Stout, K. A., Park, S. M., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150602 · Cited by 45 · see citing works
Catecholamines up integrates dopamine synthesis and synaptic trafficking
Wang, Z., Ferdousy, F., Lawal, H. O., Huang, Z., Daigle, J. G., Izevbaye, I., Doherty, O. M., Thomas, J., Stathakis, D. G., & O’Donnell, J. M. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07517.x · Cited by 42 · see citing works
A Concise Total Synthesis of (+)‐Tetrabenazine and (+)‐α‐Dihydrotetrabenazine
Paek, S., Kim, N., Shin, D., Jung, J., Jung, J., Chang, D., Moon, H., & Suh, Y. (2010) · Chemistry - A European Journal · doi:10.1002/chem.200902591 · Cited by 41 · see citing works
Natural Products in Drug Discovery: Impacts and Opportunities — An Assessment
Brahmachari, G. (2011) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814335386_0001 · Cited by 42 · see citing works
Update on the Pharmacological Treatment of Tics with Dopamine-Modulating Agents
Mogwitz, S., Buse, J., Wolff, N., & Roessner, V. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00460 · Cited by 37 · see citing works
Enzymatic Desymmetrization of Prochiral Molecules
Palomo, J. M., & Cabrera, Z. (2012) · Current Organic Synthesis · doi:10.2174/157017912803901628 · Cited by 35 · see citing works
Yu, Q., Luo, W., Deschamps, J. R., Holloway, H. W., Kopajtic, T. A., Katz, J. L., Brossi, A. R., & Greig, N. H. (2010) · ACS Medicinal Chemistry Letters · doi:10.1021/ml1000189 · Cited by 32 · see citing works
Classic animal models of Parkinson’s disease: a historical perspective
Hamadjida, A., Frouni, I., Kwan, C., & Huot, P. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000441 · Cited by 32 · see citing works
Meyer, A. C., Horton, D. B., Neugebauer, N. M., Wooters, T. E., Nickell, J. R., Dwoskin, L. P., & Bardo, M. T. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.05.033 · Cited by 31 · see citing works
Self-citationThe effect of a novel VMAT2 inhibitor, GZ-793A, on methamphetamine reward in rats
Beckmann, J. S., Denehy, E. D., Zheng, G., Crooks, P. A., Dwoskin, L. P., & Bardo, M. T. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2488-9 · Cited by 31 · see citing works
Self-citationSynthesis of (±)-Tetrabenazine by Visible Light Photoredox Catalysis
Calabretta, L. O., Maverick, E. E., & Marvin, C. C. (2015) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.5b02199 · Cited by 30 · see citing works
A Ring-Closing Metathesis-Based Approach to the Synthesis of (+)-Tetrabenazine
Johannes, M., & Altmann, K. (2012) · Organic Letters · doi:10.1021/ol301612q · Cited by 30 · see citing works
Rigau-Pérez, J. G. (1999) · PubMed · Cited by 30 · see citing works
Zheng, G., Dwoskin, L. P., Deaciuc, A. G., & Crooks, P. A. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.10.042 · Cited by 29 · see citing works
Self-citationLohoff, F. W., Lautenschlager, M. M., Mohr, J., Ferraro, T. N., Sander, T., & Gallinat, J. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.01.024 · Cited by 29 · see citing works
Drug-induced hyperkinetic movement disorders by nonneuroleptic agents
Zesiewicz, T. A., & Sullivan, K. L. (2011) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52014-2.00027-6 · Cited by 28 · see citing works
Lohoff, F. W. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-700-6_9 · Cited by 27 · see citing works
Meyer, A. C., Neugebauer, N. M., Zheng, G., Crooks, P. A., Dwoskin, L. P., & Bardo, M. T. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12373 · Cited by 24 · see citing works
Self-citationN-terminus regulation of VMAT2 mediates methamphetamine-stimulated efflux
Torres, B., & Ruoho, A. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.059 · Cited by 22 · see citing works
Dopamine D2 Receptor Relies upon PPM/PP2C Protein Phosphatases to Dephosphorylate Huntingtin Protein
Marion, S., Urs, N. M., Peterson, S. M., Sotnikova, T. D., Beaulieu, J., Gainetdinov, R. R., & Caron, M. G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.544312 · Cited by 21 · see citing works
Vartak, A. P., Nickell, J. R., Chagkutip, J., Dwoskin, L. P., & Crooks, P. A. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm900770h · Cited by 20 · see citing works
Self-citationExperimenting with Spirituality: AnalyzingThe God Genein a Nonmajors Laboratory Course
Silveira, L. A. (2008) · CBE—Life Sciences Education · doi:10.1187/cbe.07-05-0029 · Cited by 18 · see citing works
A Triple Play for Thyroid Hormone
Weatherman, R. V. (2007) · ACS Chemical Biology · doi:10.1021/cb700104v · Cited by 18 · see citing works
Beyond Alkaloids: Novel Bioactive Natural Products From Lobelia Species
Zheng, Q., Wang, Y., & Zhang, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.638210 · Cited by 17 · see citing works
Shahed, J. J., & Jankovic, J. J. (2013) · Expert Opinion on Orphan Drugs · doi:10.1517/21678707.2013.787358 · Cited by 17 · see citing works
Wilmouth, C. E., Zheng, G., Crooks, P. A., Dwoskin, L. P., & Bardo, M. T. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.09.006 · Cited by 16 · see citing works
Self-citationThe effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats
Alvers, K. M., Beckmann, J. S., Zheng, G., Crooks, P. A., Dwoskin, L. P., & Bardo, M. T. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2748-3 · Cited by 16 · see citing works
Self-citationXie, Y., Raffo, A. J., Ichise, M., Deng, S., Harris, P. E., & Landry, D. W. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.07.129 · Cited by 16 · see citing works
Connolly, A., Wallman, P., Dzahini, O., Howes, O. D., & Taylor, D. M. (2024) · Psychopharmacology · doi:10.1007/s00213-023-06488-3 · Cited by 15 · see citing works
Deletion of the vesicular monoamine transporter 1 (vmat1/slc18a1) gene affects dopamine signaling
Lohoff, F. W., Carr, G. V., Brookshire, B. R., Ferraro, T. N., & Lucki, I. (2019) · Brain Research · doi:10.1016/j.brainres.2019.01.029 · Cited by 15 · see citing works
Neurotransmitter recognition by human vesicular monoamine transporter 2
Im, D., Jormakka, M., Juge, N., Kishikawa, J.-I., Kato, T., Sugita, Y., Noda, T., Uemura, T., Shiimura, Y., Miyaji, T., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51960-z · Cited by 14 · see citing works
Synthesis of (+)- and (−)-Tetrabenazine from the Resolution of α-Dihydrotetrabenazine
Boldt, K. G., Biggers, M. S., Phifer, S. S., Brine, G. A., & Rehder, K. S. (2009) · Synthetic Communications · doi:10.1080/00397910902788125 · Cited by 14 · see citing works
Sex differences in tolerance to the locomotor depressant effects of lobeline in periadolescent rats
Harrod, S. B., & Horn, M. L. V. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.09.009 · Cited by 14 · see citing works
18F-AV-133: A Selective VMAT2-binding Radiopharmaceutical for PET Imaging of Dopaminergic Neurons
Hefti, F. F., Kung, H. F., Kilbourn, M. R., Carpenter, A. P., Clark, C. M., & Skovronsky, D. (2010) · PET Clinics · doi:10.1016/j.cpet.2010.02.001 · Cited by 14 · see citing works
Stereoselective neuroimaging in vivo
Smith, D. F., & Jakobsen, S. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.02.008 · Cited by 13 · see citing works
VMAT2 Inhibitors for Tardive Dyskinesia—Practice Implications
Peckham, A. M., & Nicewonder, J. A. (2018) · Journal of Pharmacy Practice · doi:10.1177/0897190018756512 · Cited by 12 · see citing works
Synthesis of (−)-lobeline via enzymatic desymmetrization of lobelanidine
Chênevert, R., & Morin, P. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.01.055 · Cited by 12 · see citing works
Synthesis of Lobeline, Lobelane and their Analogues. A Review
Zheng, G., & Crooks, P. A. (2015) · Organic Preparations and Procedures International · doi:10.1080/00304948.2015.1066642 · Cited by 11 · see citing works
Self-citationHojahmat, M., Horton, D. B., Norrholm, S. D., Miller, D. K., Grinevich, V. P., Deaciuc, A. G., Dwoskin, L. P., & Crooks, P. A. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.12.002 · Cited by 11 · see citing works
Self-citationA New VMAT ‐2 Inhibitor NBI ‐641449 in the Treatment of Huntington Disease
Chen, S., Zhang, X., Xie, W., Qiu, H., Liu, H., & Le, W. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12425 · Cited by 11 · see citing works
Zheng, P., Lieberman, B. P., Choi, S., Plöessl, K., & Kung, H. F. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.03.113 · Cited by 11 · see citing works
Tetrabenazine improves levodopa-induced peak-dose dyskinesias in patients with Parkinson�s disease
Brusa, L. (2013) · Functional Neurology · doi:10.11138/fneur/2013.28.2.101 · Cited by 10 · see citing works
Chen, Z., Duan, S., Li, J., Su, J., & Lei, H. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117392 · Cited by 9 · see citing works
Vesicular Neurotransmitter Transporters
Fei, H., & Krantz, D. E. (2009) · Springer eBooks · doi:10.1007/978-0-387-30370-3_7 · Cited by 9 · see citing works
The metabolism of histamine in rat hypothalamus and cortex after reserpine treatment
Maldonado, M., & Maeyama, K. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.04.005 · Cited by 9 · see citing works
Altered expression of vesicular monoamine transporter 2 in epileptic patients and experimental rats
Jiang, G., Cao, Q., Li, J., Zhang, Y., Liu, X., Wang, Z., Guo, F., Chen, Y., Chen, Y., Chen, G., et al. (2013) · Synapse · doi:10.1002/syn.21663 · Cited by 9 · see citing works
Spasojević, N., Stanisavljevic, D., Gavrilović, L., Jovanović, P., Cucakovic, A., & Dronjak, S. (2012) · PubMed · Cited by 9 · see citing works
Zheng, G., Horton, D. B., Penthala, N. R., Nickell, J. R., Culver, J. P., Deaciuc, A. G., Dwoskin, L. P., & Crooks, P. A. (2013) · MedChemComm · doi:10.1039/c3md20374c · Cited by 9 · see citing works
Self-citationBoldt, K. G., Brine, G. A., & Rehder, K. S. (2008) · Organic Preparations and Procedures International · doi:10.1080/00304940809458097 · Cited by 9 · see citing works
Zhang, X., Talpos, J. C., Berridge, M. S., Apana, S. M., Slikker, W., Wang, C., & Paule, M. G. (2021) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2021.107017 · Cited by 8 · see citing works
Effect of Carbidopa on 18F-FDOPA Uptake in Insulinoma: From Cell Culture to Small-Animal PET Imaging
Détour, J., Pierre, A., Boisson, F., Kreutter, G., Lavaux, T., Namer, I. J., Kessler, L., Brasse, D., Marchand, P., & Impériale, A. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.180588 · Cited by 8 · see citing works
Neuronal Networks Regulating Sleep and Arousal: Effect of Drugs
Szabadi, E. (2014) · Milestones in drug therapy · doi:10.1007/978-3-319-11514-6_2 · Cited by 8 · see citing works
Wu, D., Zhao, Y., & Jiang, D. (2025) · FEBS Journal · doi:10.1111/febs.70003 · Cited by 8 · see citing works
Grignard Reagents as Niche Bases in the Synthesis of Pharmaceutically Relevant Molecules
Samineni, R., Eda, V. V. R., Rao, P., Sen, S., & Oruganti, S. (2022) · ChemistrySelect · doi:10.1002/slct.202102853 · Cited by 7 · see citing works
Zheng, G., Dwoskin, L. P., Deaciuc, A. G., & Crooks, P. A. (2009) · The Journal of Organic Chemistry · doi:10.1021/jo901082r · Cited by 7 · see citing works
Self-citationChandler, C. M., Nickell, J. R., Wilson, A. G., Culver, J. P., Crooks, P. A., Bardo, M. T., & Dwoskin, L. P. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116189 · Cited by 6 · see citing works
Self-citationSrinivasan, S., Limani, F., Hanzlova, M., Batide-Alanore, S. L., Klotz, S., Hnasko, T. S., & Steinkellner, T. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110367 · Cited by 8 · see citing works
Chemical probes based on GOLD : The discovery and elucidation of mechanism
Ciaramicoli, L. M., & Chang, Y. (2023) · Bulletin of the Korean Chemical Society · doi:10.1002/bkcs.12713 · Cited by 5 · see citing works
Hankosky, E. R., Joolakanti, S. R., Nickell, J. R., Janganati, V., Dwoskin, L. P., & Crooks, P. A. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.10.039 · Cited by 5 · see citing works
Self-citationSynthesis of 3H‐labeled Tetrabenazine (TBZ)
Rhee, S., Ryan, K. J., & Tanga, M. J. (2011) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.1881 · Cited by 5 · see citing works
Simple, Rapid and Reliable Preparation of [11C]-(+)-a-DTBZ of High Quality for Routine Applications
Zhang, J., Zhang, X., Li, Y., & Tian, J. (2012) · Molecules · doi:10.3390/molecules17066697 · Cited by 5 · see citing works
Cao, L., Xie, M., Zhao, C., Tang, J., Liu, C., Xu, Y., Li, X., Liu, Y., & Chen, Z. (2018) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-018-5900-7 · Cited by 4 · see citing works
Carneiro, P., Ferreira, M., Costa, V. M., Carvalho, F. D., & Capela, J. P. (2024) · Current Research in Toxicology · doi:10.1016/j.crtox.2024.100165 · Cited by 4 · see citing works
Fjorback, A. W., Sundbye, S., Dächsel, J. C., Sinning, S., Wiborg, O., & Jensen, P. H. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07970.x · Cited by 4 · see citing works
Wiart, C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-398373-2.00001-7 · Cited by 4 · see citing works
Ajayi, I. I., Fatoki, T. H., Alonge, S. A., Balogun, T. C., Nwagwe, O. R., Moge, G. M., & Shityakov, S. (2024) · Journal of Computational Biophysics and Chemistry · doi:10.1142/s2737416524500480 · Cited by 3 · see citing works
SPECT/PET Findings in Lewy Body Dementia
Ducksbury, R., Whitfield, T. J., & Walker, Z. (2014) · Springer eBooks · doi:10.1007/978-3-642-54307-4_17 · Cited by 3 · see citing works
Xue, D., Liu, C., Li, X., Tang, J., Cao, L., Liu, Y., & Chen, Z. (2017) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-017-5333-8 · Cited by 3 · see citing works
SPECT/PET Findings in Dementia with Lewy Bodies
Zabihi, S., Whitfield, T. J., & Walker, Z. (2020) · Springer eBooks · doi:10.1007/978-3-030-53168-3_17 · Cited by 3 · see citing works
Limani, F., Srinivasan, S., Hanzlova, M., Batide-Alanore, S. L., Klotz, S., Hnaskoxs, T. S., & Steinkellner, T. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.04.602053 · Cited by 3 · see citing works
Bardo, M. T., Denehy, E. D., Hammerslag, L. R., Dwoskin, L. P., Blough, B. E., Landavazo, A., Bergman, J., & Kohut, S. J. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05327-8 · Cited by 2 · see citing works
Self-citationZhang, Y., Li, G., Sun, Y., Hong, H., Li, L., Luo, Y., Wang, R., Zhu, L., Kung, H. F., & Zhu, J. (2022) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.4005 · Cited by 2 · see citing works
Pharmacological Properties of Levodopa
Huot, P. (2014) · Springer eBooks · doi:10.1007/978-1-4471-6503-3_9 · Cited by 2 · see citing works
Therapy for dyskinesias in Parkinson‘s disease patients
Stefani, A., Pierantozzi, M., Koch, G., Galati, S., & Stanzione, P. (2009) · Future Neurology · doi:10.2217/fnl.10.9 · Cited by 2 · see citing works
- Authors
- Zheng, G., Dwoskin, L. P., & Crooks, P. A.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Crooks, Peter A.
- Venue
- The AAPS Journal
- Published
- 2006-12
- Volume
- 8
- Issue
- 4
- Pages
- E682-E692
- ISSN
- 1550-7416 (ISSN-L)
- PMC
- PMC2751365
- OpenAlex
- W2038763233
- Cited by
- 125
- References
- 131
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 8 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 8 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 11
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The AAPS Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (DA 13519)
- National Institute on Drug Abuse (DA 13519)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- vesicular monoamine transporter 2, dopamine storage, synaptic vesicles, Parkinson's disease, stimulant abuse, structure-activity relationship, drug development
- MeSH terms
- Animals, Pharmaceutical Preparations, Humans, Ligands, Protein Binding, Drug Design, Drug Delivery Systems, Vesicular Monoamine Transport Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review