Cited by 144Advanced Drug Delivery SystemsHydrogels: synthesis, properties, applicationsPolymer-Based Agricultural Enhancements

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Preparation and evaluation of chitosan/carrageenan beads for controlled release of sodium diclofenac

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Piyakulawat, Pimwipha, Praphairaksit, Nalena, Chantarasiri, Nuanphun, Muangsin, Nongnuj·2007·AAPS PharmSciTech

DOI 10.1208/pt0804097PMC PMC2750683

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Abstract

The polyelectrolyte complex (PEC) hydrogel beads based on chitosan (CS) and carrageenan (CR) have been studied as a controlled release device to deliver sodium diclofenac (DFNa) in the simulated gastrointestinal condition. Various factors potentially influencing the drug release (ie, CS/CR proportion, DFNa content, types and amount of cross-linking agents) were also investigated. The optimal formulation was obtained with CS/CR proportion of 2/1 and 5% (wt/vol) DFNa. The controlled release of the drug from this formulation was superior to other formulations and was able to maintain the release for approximately 8 hours. Upon cross-linking with glutaric acid and glutaraldehyde, the resulting beads were found to be more efficient for prolonged drug release than their non-cross-linking counterparts. The bead cross-linked with glutaraldehyde was able to control the release of the drug over 24 hours. The difference in the drug release behavior can be attributed to the differences in ionic interaction between the oppositely charged ions and to the concentrations of the drug within the beads, which depends on the compositions of the formulation and the pH of the dissolution medium. The release of drug was controlled by the mechanism of the dissolution of DFNa in the dissolution medium and the diffusion of DFNa through the hydrogel beads.

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Authors: Piyakulawat, P., Praphairaksit, N., Chantarasiri, N., & Muangsin, N.
Affiliations: Chulalongkorn University (TH)
Srinakharinwirot University (TH)
Corresponding author: Muangsin, Nongnuj
ORCID: Praphairaksit, Nalena
Muangsin, Nongnuj
Venue: AAPS PharmSciTech
Publisher: Springer Science and Business Media LLC
Published: 2007-10
Volume: 8
Issue: 4
Pages: E97-E97
ISSN: 1530-9932 (ISSN-L)
DOI: 10.1208/pt0804097
PMC: PMC2750683
OpenAlex: W2041581549
Cited by: 144
References: 27
Citations by year: 2026: 4 · 2024: 2 · 2023: 10 · 2022: 10 · 2021: 10 · 2020: 7 · 2019: 12 · 2018: 11 · 2017: 3 · 2016: 12 · 2015: 7 · 2014: 7 · 2013: 12 · 2012: 6
FWCI: 5.70
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: AAPS PharmSciTech (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Chulalongkorn University
Thailand Research Fund (RTA4880008)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Polymer-Based Agricultural Enhancements
Keywords: chitosan, carrageenan, polyelectrolyte complex hydrogels, beads, controlled drug release, diclofenac sodium, crosslinking agents, glutaraldehyde, glutaric acid, gastrointestinal drug delivery, ionic interactions, drug diffusion, sustained drug release
MeSH terms: Anti-Inflammatory Agents, Non-Steroidal, Calorimetry, Differential Scanning, Capsules, Carrageenan, Chemistry, Pharmaceutical, Cross-Linking Reagents, Delayed-Action Preparations, Diclofenac, Diffusion, Drug Carriers, Drug Compounding, Glutaral, Glutarates, Hydrogen-Ion Concentration, Kinetics, Particle Size, Solubility, Surface Properties, Technology, Pharmaceutical, Thermogravimetry, Spectroscopy, Fourier Transform Infrared, Hydrogels, Chitosan

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Preparation and evaluation of chitosan/carrageenan beads for controlled release of sodium diclofenac

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