The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Preparation and evaluation of chitosan/carrageenan beads for controlled release of sodium diclofenac
Open accessAbstract
The polyelectrolyte complex (PEC) hydrogel beads based on chitosan (CS) and carrageenan (CR) have been studied as a controlled release device to deliver sodium diclofenac (DFNa) in the simulated gastrointestinal condition. Various factors potentially influencing the drug release (ie, CS/CR proportion, DFNa content, types and amount of cross-linking agents) were also investigated. The optimal formulation was obtained with CS/CR proportion of 2/1 and 5% (wt/vol) DFNa. The controlled release of the drug from this formulation was superior to other formulations and was able to maintain the release for approximately 8 hours. Upon cross-linking with glutaric acid and glutaraldehyde, the resulting beads were found to be more efficient for prolonged drug release than their non-cross-linking counterparts. The bead cross-linked with glutaraldehyde was able to control the release of the drug over 24 hours. The difference in the drug release behavior can be attributed to the differences in ionic interaction between the oppositely charged ions and to the concentrations of the drug within the beads, which depends on the compositions of the formulation and the pH of the dissolution medium. The release of drug was controlled by the mechanism of the dissolution of DFNa in the dissolution medium and the diffusion of DFNa through the hydrogel beads.
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“In a previous study, the drug release rate increased from 15% at pH of 1.2%–80% with the in pH of 7.4 of the medium (Kotwal et al., 2007).”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Kotwal et al., 2007
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Rizwan, M., Yahya, R., Hassan, A., Yar, M., Azzahari, A., Selvanathan, V., Sonsudin, F., & Abouloula, C. (2017) · Polymers · doi:10.3390/polym9040137 · Cited by 844
Luo, Y., & Wang, Q. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.12.017 · Cited by 837
Ahmed, T. A., & Aljaeid, B. M. (2016) · Drug Design Development and Therapy · doi:10.2147/dddt.s99651 · Cited by 710
Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications
Cunha, L., & Grenha, A. (2016) · Marine Drugs · doi:10.3390/md14030042 · Cited by 620
Metadata
- Authors
- Piyakulawat, P., Praphairaksit, N., Chantarasiri, N., & Muangsin, N.
- Affiliations
- Chulalongkorn University (TH)
- Srinakharinwirot University (TH)
- Corresponding author
- Muangsin, Nongnuj
- Venue
- AAPS PharmSciTech
- Published
- 2007-10
- Volume
- 8
- Issue
- 4
- Pages
- E97-E97
- ISSN
- 1530-9932 (ISSN-L)
- PMC
- PMC2750683
- OpenAlex
- W2041581549
- Cited by
- 144
- References
- 27
- Citations by year
- 2026: 4 · 2024: 2 · 2023: 10 · 2022: 10 · 2021: 10 · 2020: 7 · 2019: 12 · 2018: 11 · 2017: 3 · 2016: 12 · 2015: 7 · 2014: 7 · 2013: 12 · 2012: 6
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AAPS PharmSciTech (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chulalongkorn University
- Thailand Research Fund (RTA4880008)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Polymer-Based Agricultural Enhancements
- Keywords
- chitosan, carrageenan, polyelectrolyte complex hydrogels, beads, controlled drug release, diclofenac sodium, crosslinking agents, glutaraldehyde, glutaric acid, gastrointestinal drug delivery, ionic interactions, drug diffusion, sustained drug release
- MeSH terms
- Anti-Inflammatory Agents, Non-Steroidal, Calorimetry, Differential Scanning, Capsules, Carrageenan, Chemistry, Pharmaceutical, Cross-Linking Reagents, Delayed-Action Preparations, Diclofenac, Diffusion, Drug Carriers, Drug Compounding, Glutaral, Glutarates, Hydrogen-Ion Concentration, Kinetics, Particle Size, Solubility, Surface Properties, Technology, Pharmaceutical, Thermogravimetry, Spectroscopy, Fourier Transform Infrared, Hydrogels, Chitosan
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