Chitosan-Modified PLGA Nanoparticles with Versatile Surface for Improved Drug Delivery

Wang, Yichao; Li, Puwang; Kong, Lingxue

doi:10.1208/s12249-013-9943-3

Cited by 305Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsDendrimers and Hyperbranched Polymers

Chitosan-Modified PLGA Nanoparticles with Versatile Surface for Improved Drug Delivery

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Wang, Yichao, Li, Puwang, Kong, Lingxue·2013·AAPS PharmSciTech

DOI 10.1208/s12249-013-9943-3PMC PMC3665987

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Abstract

Shortage of functional groups on surface of poly(lactide-co-glycolide) (PLGA)-based drug delivery carriers always hampers its wide applications such as passive targeting and conjugation with targeting molecules. In this research, PLGA nanoparticles were modified with chitosan through physical adsorption and chemical binding methods. The surface charges were regulated by altering pH value in chitosan solutions. After the introduction of chitosan, zeta potential of the PLGA nanoparticle surface changed from negative charge to positive one, making the drug carriers more affinity to cancer cells. Functional groups were compared between PLGA nanoparticles and chitosan-modified PLGA nanoparticles. Amine groups were exhibited on PLGA nanoparticle surface after the chitosan modification as confirmed by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. The modified nanoparticles showed an initial burst release followed by a moderate and sustained release profile. Higher percentage of drugs from cumulative release can be achieved in the same prolonged time range. Therefore, PLGA nanoparticles modified by chitosan showed versatility of surface and a possible improvement in the efficacy of current PLGA-based drug delivery system.

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PLGA and chitosan are biodegradable materials that break down into non-toxic byproducts, reducing the risk of long-term nanoparticle accumulation and making them safer for medical applications.
“Common materials like PLGA and chitosan are often used in NP formulations because they break down naturally in the body into non-toxic byproducts, making them safer for medical and therapeutic applications [171].”
From Targeted Nanoparticles for Drug Delivery Across the Blood–Brain Barrier in Early and Late Stages of Alzheimer's Disease: A Review (2026) · cites this paper as [171]
The Introduction (page unavailable) describes both PLGA and chitosan as biodegradable and biocompatible, and says PLGA breaks down into nontoxic products that are rapidly metabolized in the body. It does not say that chitosan's breakdown products are nontoxic or address long-term nanoparticle accumulation. (LLM, conf=0.85)
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Self-citation
Preparation and hydrolytic erosion of differently structured PLGA nanoparticles with chitosan modification
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Authors: Wang, Y., Li, P., & Kong, L.
Affiliations: Deakin University (AU)
Chinese Academy of Tropical Agricultural Sciences (CN)
Corresponding author: Kong, Lingxue
ORCID: Wang, Yichao
Li, Puwang
Kong, Lingxue
Venue: AAPS PharmSciTech
Publisher: Springer Science and Business Media LLC
Published: 2013-03-06
Volume: 14
Issue: 2
Pages: 585-592
ISSN: 1530-9932 (ISSN-L)
DOI: 10.1208/s12249-013-9943-3
PMC: PMC3665987
OpenAlex: W2100809064
Cited by: 305
References: 30
Citations by year: 2026: 20 · 2025: 25 · 2024: 34 · 2023: 31 · 2022: 32 · 2021: 24 · 2020: 31 · 2019: 27 · 2018: 17 · 2017: 22 · 2016: 20 · 2015: 14 · 2014: 7 · 2013: 1
FWCI: 5.34
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: AAPS PharmSciTech (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Keywords: PLGA nanoparticles, chitosan modification, surface functionalization, drug carriers, zeta potential, pH-dependent surface charge, amino groups, drug release kinetics, sustained drug release, tumor targeting, physisorption, chemical conjugation
MeSH terms: Polylactic Acid-Polyglycolic Acid Copolymer, Antimetabolites, Antineoplastic, Chemistry, Pharmaceutical, Delayed-Action Preparations, Drug Carriers, Fluorouracil, Hydrogen-Ion Concentration, Kinetics, Polyglycolic Acid, Solubility, Surface Properties, Technology, Pharmaceutical, Spectroscopy, Fourier Transform Infrared, Lactic Acid, Nanotechnology, Chitosan, Nanoparticles, Photoelectron Spectroscopy

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Chitosan-Modified PLGA Nanoparticles with Versatile Surface for Improved Drug Delivery

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