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Raman Spectroscopy for Process Analytical Technologies of Pharmaceutical Secondary Manufacturing

Nagy, Brigitta, Farkas, Attila, Borbás, Enikő, Vass, Panna, Nagy, Zsombor Kristóf, Marosi, György·2019·AAPS PharmSciTech
DOI 10.1208/s12249-018-1201-2
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Abstract

As the process analytical technology (PAT) mindset is progressively introduced and adopted by the pharmaceutical companies, there is an increasing demand for effective and versatile real-time analyzers to address the quality assurance challenges of drug manufacturing. In the last decades, Raman spectroscopy has emerged as one of the most promising tools for non-destructive and fast characterization of the pharmaceutical processes. This review summarizes the achieved results of the real-time application of Raman spectroscopy in the field of the secondary manufacturing of pharmaceutical solid dosage forms, covering the most common secondary process steps of a tablet production line. In addition, the feasibility of Raman spectroscopy for real-time control is critically reviewed, and challenges and possible approaches to moving from real-time monitoring to process analytically controlled technologies (PACT) are discussed.

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Metadata

Authors
Nagy, B., Farkas, A., Borbás, E., Vass, P., Nagy, Z. K., & Marosi, G.
Venue
AAPS PharmSciTech
Publisher
Springer Science and Business Media LLC
Published
2018-12-17
Volume
20
Issue
1
ISSN
1530-9932
DOI
10.1208/s12249-018-1201-2
Cited by
89
References
1
Language
en
Licence
www.springer.com/tdm (tdm)

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