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Time to diagnosis in Cushing's syndrome: a meta-analysis based on 5367 patients
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Context: Signs and symptoms of Cushing’s syndrome (CS) overlap with common diseases, such as the metabolic syndrome, obesity, osteoporosis, and depression. Therefore, it can take years to finally diagnose CS, although early diagnosis is important for prevention of complications. Objective: The aim of this study was to assess the time span between first symptoms and diagnosis of CS in different populations to identify factors associated with an early diagnosis. Data Sources: A systematic literature search via PubMed was performed to identify studies reporting on time to diagnosis in CS. In addition, unpublished data from patients of our tertiary care center and 4 other centers were included. Study Selection: Clinical studies reporting on the time to diagnosis of CS were eligible. Corresponding authors were contacted to obtain additional information relevant to the research question. Data Extraction: Data were extracted from the text of the retrieved articles and from additional information provided by authors contacted successfully. From initially 3326 screened studies 44 were included. Data Synthesis: Mean time to diagnosis for patients with CS was 34 months (ectopic CS: 14 months; adrenal CS: 30 months; and pituitary CS: 38 months; P < .001). No difference was found for gender, age (<18 and ≥18 years), and year of diagnosis (before and after 2000). Patients with pituitary CS had a longer time to diagnosis in Germany than elsewhere. Conclusions: Time to diagnosis differs for subtypes of CS but not for gender and age. Time to diagnosis remains to be long and requires to be improved.
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“These challenges often lead to delayed diagnosis, contributing to increased morbidity and mortality (48-50, 53).”
From Measuring cortisol in Cushing syndrome: diagnosis, monitoring, and cortisol circadian rhythm improvement. (2026) · cites this paper as [50]
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“The diagnosis of endogenous CS can be challenging due to overlap with common conditions, highly variable clinical features, and challenges in appropriately interpreting biochemical screening and diagnostic tests (11, 48-52).”
From Measuring cortisol in Cushing syndrome: diagnosis, monitoring, and cortisol circadian rhythm improvement. (2026) · cites this paper as [50]
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Cites
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline.
Nieman, L. K., Biller, B. M. K., Findling, J. W., Newell-Price, J., Savage, M. O., Stewart, P. M., & Montori, V. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0125 · Cited by 2,718
Lacroix, A., Feelders, R. A., Stratakis, C. A., & Nieman, L. K. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61375-1 · Cited by 1,777
Why rare diseases are an important medical and social issue
Schieppati, A., Henter, J., Daina, E., & Aperia, A. C. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60872-7 · Cited by 620
Diagnosis and Management of Cushing's Syndrome: Results of an Italian Multicentre Study
Invitti, C., Giraldi, F. P., Martin, M. D., & Cavagnini, F. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.2.440 · Cited by 467
Valassi, E., Santos, A., Yaneva, M., Tóth, M., Strasburger, C. J., Chanson, P., Wass, J. A. H., Chabre, O., Pfeifer, M., Feelders, R. A., et al. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0272 · Cited by 402
Self-citationCushing's syndrome: update on signs, symptoms and biochemical screening
Nieman, L. K. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0464 · Cited by 385
Faggiano, A., Pivonello, R., Spiezia, S., De Martino, M. C., Filippella, M., Di Somma, C., Lombardi, G., & Colao, A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021558 · Cited by 358
Bochicchio, D., Losa, M., & Buchfelder, M. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.11.7593411 · Cited by 344
Self-citationDiagnosis and Management of Cushing’s Syndrome: Results of an Italian Multicentre Study 1
Invitti, C., Giraldi, F. P., De Martin, M., & Cavagnini, F. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5465 · Cited by 336
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Research works printed but not linked: 1
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Items 101–182 of 182
Bromińska, B., Sawicka‐Gutaj, N., Szczepanek‐Parulska, E., Lange‐Ratajczak, M., Wierzbicki, T., Janicka‐Jedyńska, M., Czepczyński, R., & Ruchała, M. A. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1580876 · Cited by 1
“In contrast, for other ectopic and pituitary Cushing syndrome, the time to establish a diagnosis is signi fi cantly longer — 14 and 38 months, respectively (20).”
Ectopic ACTH syndrome complicated by hypercortisolism-associated urolithiasis. A case report
de León-Castorena, E., López-Sotomayor, D. M., Gaona-Garza, L. E., Treviño-Aguillón, M. A., & Mendoza, A. (2022) · International Journal of Surgery Case Reports · doi:10.1016/j.ijscr.2022.107449 · Cited by 1
Bilger, N., Cerit, M. N., Babayeva, A., Fatullayeva, T., Yalçın, M. M., Altınova, A. E., Törüner, F. B., & Aktürk, M. (2024) · HORMONES · doi:10.1007/s42000-024-00590-7 · Cited by 2
“A meta-analysis reported that patients with pituitary CD had a longer time to diagnosis than patients with adrenal CS, but it did not reach statistical significance [ 23].”
Ceccato, F., Terzolo, M., & Scaroni, C. M. (2024) · Journal of Endocrinological Investigation · doi:10.1007/s40618-024-02449-5 · Cited by 1
“Actually, CS is diagnosed approximately three years late [8] in a patient with a peculiar clinical picture after months/ years of consultations and unnecessary biochemical or imaging studies.”
Self-citationAraya, A. V., Liberman, C., Munizaga, C., Pineda, P., Marcela Barberán, M., Cordero, F., Lanas, A., & Toro, L. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.106521 · Cited by 1
Holzer, K. (2022) · Springer Reference Medizin · doi:10.1007/978-3-662-63317-5_32 · Cited by 1
Kapfhammer, H. (2022) · Springer eBooks · doi:10.1007/978-3-662-65873-4_9 · Cited by 1
Ragnarsson, Ó. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-96120-2.00006-6 · Cited by 1
Liu, T., Yu, H., Wang, S., Li, H., & He, X. (2022) · Research Square · doi:10.21203/rs.3.rs-1490805/v1 · Cited by 1
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Bengtsson, D. (2021) · Linköping University medical dissertations · doi:10.3384/diss.diva-174806
The diagnosis of Cushing's disease
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Melicharová, K., Brunerová, L., Urbanová, J., & Brož, J. (2021) · Vnitřní lékařství · doi:10.36290/vnl.2021.044
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Holzer, K. (2021) · Springer Reference Medizin · doi:10.1007/978-3-662-61724-3_32-1
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Melo, I. M., Dias, A. F., de Aguiar, L. A., Fidelis, B. C. A., Nunes, M. R., & Maciel, T. (2022) · Research Society and Development · doi:10.33448/rsd-v11i13.35218
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Daga, M. K., Chand, S., Kumar, N. P., Mawari, G., Raghu, R., & Aarthi, J. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815123371123030005
Honour, J. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-818124-9.00019-x
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Silva, J. F. D., Malta, W. V., Silva, M. E. R. D., Santos, W. A. C. D., Silva, L. D. S., dos Santos, V. L. A., Silva, V. R. U. D., da Silva, M. S. F., Silva, M. C. D., & Moraes, J. M. D. S. (2023) · Brazilian Journal of Health Review · doi:10.34119/bjhrv6n6-097
Krzentowska, A., Gołkowski, F., & Czepko, R. A. (2023) · The Journal of Neurological and Neurosurgical Nursing · doi:10.15225/pnn.2023.12.3.5
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“In this case, despite marked hypercortisolism secondary to ectopic ACTH syndrome, the patient’s time from first symptoms to diagnosis was more than 3 years, far in excess of the typical time to diagnosis in this subtype, noted to be 14 months in 1 study (1).”
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Liu, T., Yu, H., Wang, S., Li, H., Du, X., & He, X. (2023) · Figshare · doi:10.6084/m9.figshare.22607428
Liu, T., Yu, H., Wang, S., Li, H., Du, X., & He, X. (2023) · Figshare · doi:10.6084/m9.figshare.22607425
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Ragnarsson, Ó., & Falhammar, H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00114-x
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Alfawaz, F. S., Alsaadi, M. M., Alotaibi, S. S., Anazi, N. A. A., Alotaibi, A. B., Al-Arej, I. M., Alsayegh, A. S., Alduaybi, M. A., Owias, M. I. Z. A., Alnughaymishi, A. A. S., et al. (2021) · International Journal of Health Sciences · doi:10.53730/ijhs.v5ns1.15303
Díez, J. J., Anda, E., Bretón, I., González, C., Miguélez, M., Zugasti, A., & Fernández, A. (2024) · Endocrinología Diabetes y Nutrición · doi:10.1016/j.endinu.2024.11.001 · Cited by 1
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Artificial Intelligence in Endocrinology: Balancing Innovation and Evidence
Lieb, D. C. (2025) · Endocrine Practice · doi:10.1016/j.eprac.2025.11.001
Deng, H., Lin, S., He, H., Xie, S., Chen, J., Zeng, L., & Xu, W. (2025) · Medicine Plus · doi:10.1016/j.medp.2025.100109
Aung, Y. M., Hutton, N., Hamdan, S., Hadden, R., & Babiker, T. (2025) · Cureus · doi:10.7759/cureus.97772
“As the duration of hypercortisolism appears to be the most relevant determinant of morbidity and premature mortality, it also significantly influences symptom resolution and patient recovery, especially in terms of psychiatric outcomes [11].”
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Iglesias, P., González, J. H. M., González‐Vioque, E., & Corbacho, C. (2025) · Endocrinología Diabetes y Nutrición (English ed ) · doi:10.1016/j.endien.2026.501728
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van Paassen, J., Vos, J. S., Hoekstra, E. M., Neumann, K. M. I., Boot, P. C., & Arbous, M. S. (2020) · Figshare · doi:10.6084/m9.figshare.13468013
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Lutsenko, A., Kutakova, D. V., Vikulova, O., Isakov, M. A., Belaya, Z., Przhiyalkovskaya, E., Rozhinskaya, L., Dzeranova, L., Pigarova, E., Marova, E., et al. (2026) · Obesity and Metabolism · doi:10.14341/omet13298
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“However, in cases like ours, where disease manifests aggressively, the diag - nosis can be reached more rapidly [10].”
Zeng, W., Schwartz, G. M., Prasad, A., Jedwood, C., John, D., Chung, R. S., Hong, A. T., Cote, D. J., Dallas, J., Briggs, R. G., et al. (2026) · Neurosurgery · doi:10.1227/neu.0000000000004022
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An Overview of Cushing’s Syndrome Caused by Ectopic Adrenocorticotropin Secretion
Ilias, Ι., Maggio, V., Ispas, S., Hoffmann, K., Paczkowska, A., Арманович, А. А., Rangraze, I. R., Wali, A. F., Talath, S., Rabbani, S. A., et al. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15208192
“A meta-analysis established the mean time to diagnosis for ECS as 14 months and for CD as 38 months [34].”
Metadata
- Authors
- Rubinstein, G., Osswald, A., Hoster, E., Losa, M., Elenkova, A., Zacharieva, S., Machado, M. C., Hanzu, F. A., Zopp, S., Ritzel, K., Riester, A., Braun, L. T., Kreitschmann-Andermahr, I., Storr, H. L., Bansal, P., Barahona, M.-J., Cosaro, E., Dogansen, S. C., Johnston, P. C., Santos de Oliveira, R., Raftopoulos, C., Scaroni, C., Valassi, E., van der Werff, S. J. A., Schopohl, J., Beuschlein, F., & Reincke, M.
- Affiliations
- LMU Klinikum (DE)
- Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie (DE)
- Vita-Salute San Raffaele University (IT)
- Medical University of Sofia (BG)
- Universidade de São Paulo (BR)
- Hospital Clínic de Barcelona (ES)
- Neurochirurgische Klinik, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, Germany
- Queen Mary University of London (GB)
- King Edward Memorial Hospital and Seth G.S. Medical College (IN)
- University Hospital Mútua de Terrassa (ES)
- University of Verona (IT)
- Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul, Turkey
- Royal Victoria Hospital (GB)
- Division of Pediatric Neurosurgery of the Department of Surgery and Anatomy, University Hospital of Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil
- UCLouvain (BE)
- University of Padua (IT)
- Universitat Autònoma de Barcelona (ES)
- Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
- Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Germany
- ORCID
- Rubinstein, German
- Osswald, Andrea
- Hoster, Eva
- Losa, Marco
- Elenkova, Atanaska
- Zacharieva, Sabina
- Machado, Márcio Carlos
- Hanzu, Felicia Alexandra
- Zopp, Stephanie
- Ritzel, Katrin
- Riester, Anna
- Braun, Leah Theresa
- Storr, Helen L
- Barahona, María-José
- Johnston, Philip C
- Raftopoulos, Christian
- Scaroni, Carla
- Valassi, Elena
- Schopohl, Jochen
- Beuschlein, Felix
- Reincke, Martin
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2019-10-29
- Volume
- 105
- Issue
- 3
- Pages
- e12-e22
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2949356757
- Semantic Scholar
- 76b4317201b4458ff9a1ddd19101a38655092f73
- Cited by
- 180
- References
- 66
- Citations by year
- 2026: 29 · 2025: 31 · 2024: 30 · 2023: 25 · 2022: 28 · 2021: 17 · 2020: 16 · 2019: 2
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Licence
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion, other-oa)
- DIAL (Catholic University of Leuven) (submittedVersion, other-oa)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Else Kröner-Fresenius Stiftung (2012_A103, 2015_A228)
- Deutsche Forschungsgemeinschaft (314061271-TRR 205)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- Cushing's syndrome, time to diagnosis, delayed diagnosis, ectopic ACTH syndrome, adrenal Cushing's syndrome, early diagnosis
- MeSH terms
- Age Factors, Cushing Syndrome, Humans, Sex Factors, Time Factors, Early Diagnosis, Delayed Diagnosis
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