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Brain and Pituitary Angiotensin
Abstract
Angiotensin(ANG II) was discovered about 50 yr ago (1, 2), and a complete peripheral system for the formation and metabolism of ANG II was soon characterized. It was named the renin-angiotensin system, based on the rate-limiting enzyme, renin, and the active principle, ANG II (3). In the classical peripheral RAS system, a precursor molecule, angiotensinogen (AOGEN), originates in the liver and is cleaved to the essentially inactive decapeptide angiotensin I (ANG I) by an aspartyl protease, renin, synthesized and released to the circulation mainly by the juxtaglomerular cells of the kidney. ANG I is converted to ANG II, the effector peptide of this system, by the angiotensin-converting enzyme (ACE) (4). Circulating ANG II acts on high affinity ANG II receptors located in the vascular smooth muscle, zona glomerulosa of the adrenal gland, and kidney to produce vasoconstriction, aldosterone release, and sodium retention, respectively. Thus, the peripheral RAS is a hormonal system with important functions in the regulation of blood pressure and fluid homeostasis.
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Cited by
Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
Neuroendocrine Control of Body Fluid Metabolism
ANTUNES-RODRIGUES, J., DE CASTRO, M., ELIAS, L. L. K., VALENÇA, M. M., & McCANN, S. M. (2004) · Physiological Reviews · doi:10.1152/physrev.00017.2003 · Cited by 468
Lenkei, Z., Palkovits, M., Corvol, P., & Llorens-Cortès, C. (1997) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1997.0155 · Cited by 406
Angiotensin II AT1 Receptor Blockade Ameliorates Brain Inflammation
Benicky, J., Sánchez-Lemus, E., Honda, M., Pang, T., Orecna, M., Wang, J., Leng, Y., Chuang, D.-M., & Saavedra, J. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.225 · Cited by 254
Self-citationArmando, I., Carranza, A., Nishimura, Y., Hoe, K.-L., Barontini, M., Terrón, J. A., Falcón-Neri, A., Ito, T., Juorio, A. V., & Saavedra, J. M. (2001) · Endocrinology · doi:10.1210/endo.142.9.8366 · Cited by 148
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Metadata
- Authors
- SAAVEDRA, J. M.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 1992-05
- Volume
- 13
- Issue
- 2
- Pages
- 329-380
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W1970388701
- Cited by
- 466
- References
- 0
- FWCI
- 19.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- SAAVEDRA, J. M. (1992). Brain and Pituitary Angiotensin. Endocrine Reviews. https://doi.org/10.1210/edrv-13-2-329
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
