Peripheral Administration of an Angiotensin II AT1 Receptor Antagonist Decreases the Hypothalamic-Pituitary-Adrenal Response to Isolation Stress
Abstract
Angiotensin II, which stimulates AT(1) receptors, is a brain and peripheral stress hormone. We pretreated rats with the AT(1) receptor antagonist candesartan for 13 d via sc-implanted osmotic minipumps, followed by 24-h isolation in individual metabolic cages. We measured angiotensin II receptor-type binding and mRNAs and tyrosine hydroxylase mRNA by quantitative autoradiography and in situ hybridization, catecholamines by HPLC, and hormones by RIA. Isolation increased AT(1) receptor binding in hypothalamic paraventricular nucleus as well as anterior pituitary ACTH, and decreased posterior pituitary AVP. Isolation stress also increased AT(1) receptor binding and AT(1B) mRNA in zona glomerulosa and AT(2) binding in adrenal medulla, adrenal catecholamines, tyrosine hydroxylase mRNA, aldosterone, and corticosterone. Candesartan blocked AT(1) binding in paraventricular nucleus and adrenal gland; prevented the isolation-induced alterations in pituitary ACTH and AVP and in adrenal corticosterone, aldosterone, and catecholamines; abolished the increase in AT(2) binding in adrenal medulla; and substantially decreased urinary AVP, corticosterone, aldosterone, and catecholamines during isolation. Peripheral pretreatment with an AT(1) receptor antagonist blocks brain and peripheral AT(1) receptors and inhibits the hypothalamic-pituitary-adrenal response to stress, suggesting a physiological role for peripheral and brain AT(1) receptors during stress and a possible beneficial effect of AT(1) antagonism in stress-related disorders.
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Adrenal ACTH and corticosterone are increased in male rats isolated for 24 hours in a novel environment.
“both adrenal ACTH and corticosterone are increased in male rats isolated for 24 h in a novel environment74,75.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [74]
Isolation-induced CRF changes were accompanied by increased ATII AT1 receptor expression in the PVN.
“these changes in CRF were accompanied by enhanced angiotensin II (ATII) AT1 receptor expression in the PVN74.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [74]
Cites
Angiotensin II receptors and angiotensin II receptor antagonists.
Timmermans, P. B. M. W. M., Wong, P. C., Chiu, A. T., Herblin, W. F., Benfield, P. A., Carini, D. J., Lee, R. J., Wexler, R. R., Saye, J. A., & Smith, R. D. (1993) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00446-6 · Cited by 1,854 · see citing works
Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor
Murphy, T. J., Alexander, R. W., Griendling, K. K., Runge, M. S., & Bernstein, K. E. (1991) · Nature · doi:10.1038/351233a0 · Cited by 1,250 · see citing works
Mukoyama, M., Nakajima, M., Horiuchi, M., Sasamura, H., Pratt, R. E., & Dzau, V. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74498-6 · Cited by 768 · see citing works
Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age
Antoni, F. A. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1004 · Cited by 636 · see citing works
Complete coding sequence of rat tyrosine hydroxylase mRNA.
Grima, B., Lamouroux, A., Blanot, F., Biguet, N. F., & Mallet, J. J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.2.617 · Cited by 534 · see citing works
Brain and Pituitary Angiotensin
Saavedra, J. M. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-2-329 · Cited by 460 · see citing works
Self-citationCharacterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brain
Tsutsumi, K., & Saavedra, J. M. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.261.1.r209 · Cited by 336 · see citing works
Self-citationAngiotensin II type-1 receptor subtype cDNAs: Differential tissue expression and hormonal regulation
Kakar, S. S., Sellers, J. C., Devor, D. C., Musgrove, L. C., & Neill, J. D. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80302-x · Cited by 326 · see citing works
Wong, P. C., Hart, S. D., Zaspel, A. M., Chiu, A. T., Ardecky, R., Smith, R. D., & Timmermans, P. B. M. W. M. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23123-8 · Cited by 295 · see citing works
Angiotensin II in central nervous system physiology
Phillips, M. I., & Sumners, C. (1998) · Regulatory Peptides · doi:10.1016/s0167-0115(98)00122-0 · Cited by 245 · see citing works
Dissociation of oxytocin, vasopressin and corticotropin secretion during different types of stress
Gibbs, D. M. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90241-8 · Cited by 233 · see citing works
Angiotensin II receptor subtypes and biological responses in the adrenal cortex and medulla.
Balla, T., Baukal, A. J., Eng, S. P., & Catt, K. J. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)12929-5 · Cited by 165 · see citing works
Nazarali, A. J., Gutkind, J. S., & Saavedra, J. M. (1989) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(89)90135-0 · Cited by 156 · see citing works
Self-citationTsutsumi, K., Strömberg, C., VISWANATHAN, M., & Saavedra, J. M. (1991) · Endocrinology · doi:10.1210/endo-129-2-1075 · Cited by 148 · see citing works
Self-citationThe AT2 receptor: fact, fancy and fantasy
Marc De Gasparo, B., & Siragy, H. M. (1999) · Regulatory Peptides · doi:10.1016/s0167-0115(99)00023-3 · Cited by 146 · see citing works
Direct Regulation of Hypothalamic Corticotropin-Releasing-Hormone Neurons by Angiotensin II
Aguilera, G., Young, W. S., Kiss, A., & Bathia, A. (2008) · Neuroendocrinology · doi:10.1159/000126866 · Cited by 144 · see citing works
Nishimura, Y., Ito, T., Hoe, K., & Saavedra, J. M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02377-5 · Cited by 136 · see citing works
Self-citationĊastrén, E., & Saavedra, J. M. (1988) · Endocrinology · doi:10.1210/endo-122-1-370 · Cited by 129 · see citing works
Self-citationJežová, D., Ochędalski, T., Kiss, A., & Aguilera, G. (1998) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1998.00182.x · Cited by 127 · see citing works
Effects of isolation, handling and novelty on the pituitary-adrenal response in the mouse
Misslin, R., Herzog, F., Koch, B., & Ropartz, P. (1982) · Psychoneuroendocrinology · doi:10.1016/0306-4530(82)90015-4 · Cited by 121 · see citing works
Molecular biology of angiotensin II receptors: an overview.
Inagami, T., Guo, D., & Kitami, Y. (1994) · PubMed · Cited by 121 · see citing works
AT1A, AT1B, and AT2angiotensin II receptor subtype gene expression in rat brain
Jöhren, O., Inagami, T., & Saavedra, J. M. (1995) · Neuroreport · doi:10.1097/00001756-199512150-00024 · Cited by 114 · see citing works
Self-citationAguilera, G., KISS, A. J., & Luo, X. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00714.x · Cited by 103 · see citing works
Changes in Circulating and Tissue Angiotensin II during Acute and Chronic Stress
Yang, G., Xi, Z., Wan, Y., Wang, H., & Bi, G. (1993) · Neurosignals · doi:10.1159/000109488 · Cited by 97 · see citing works
Cross-talk between angiotensin II receptors and the tyrosine kinases and phosphatases.
Inagami, T., Eguchi, S., Numaguchi, K., Motley, E. D., Tang, H., Matsumoto, T., & Yamakawa, T. (1999) · PubMed · Cited by 89 · see citing works
Factors controlling steroid biosynthesis in the zona glomerulosa of the adrenal
Aguilera, G. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90134-i · Cited by 85 · see citing works
Emerging features of brain angiotensin receptors
Saavedra, J. M. (1999) · Regulatory Peptides · doi:10.1016/s0167-0115(99)00081-6 · Cited by 84 · see citing works
Self-citationĊastrén, E., & Saavedra, J. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.2.725 · Cited by 74 · see citing works
Self-citationTsutsumi, K., & Saavedra, J. M. (1991) · Endocrinology · doi:10.1210/endo-129-6-3001 · Cited by 70 · see citing works
Self-citationBui, J. D., Kimura, B., & Phillips, M. I. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90593-s · Cited by 67 · see citing works
Sumitomo, T., Suda, T., Nakano, Y., TOZAWA, F., YAMADA, M., & Demura, H. (1991) · Endocrinology · doi:10.1210/endo-128-5-2248 · Cited by 66 · see citing works
Expression of AT1A and AT1B angiotensin II receptor messenger RNA in forebrain of 2-wk-old rats
Jöhren, O., & Saavedra, J. M. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.1.e104 · Cited by 65 · see citing works
Self-citationJöhren, O., Sanvitto, G. L., Egidy, G., & Saavedra, J. M. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08283.1997 · Cited by 57 · see citing works
Self-citationThe genomic organization of the rat angiotensin II receptor AT1B
Guo, D., & Inagami, T. (1994) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(94)90105-8 · Cited by 54 · see citing works
Belloni, A. S., Andreis, P. G., Macchi, V., Gottardo, G., Malendowicz, L. K., & Nussdorfer, G. G. (1998) · Endocrine Research · doi:10.3109/07435809809031865 · Cited by 53 · see citing works
Angiotensin II receptor subtypes and phosphoinositide hydrolysis in rat adrenal medulla
Israel, A. L., Strömberg, C., Tsutsumi, K., Garrido, M. D. R., Torres, M., & Saavedra, J. M. (1995) · Brain Research Bulletin · doi:10.1016/0361-9230(95)02011-f · Cited by 53 · see citing works
Self-citationJöhren, O., Inagami, T., & Saavedra, J. M. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00309-g · Cited by 50 · see citing works
Self-citationQuantitative autoradiography of angiotensin II AT2 receptors with [125I]CGP 42112
Heemskerk, F. M. J., & Saavedra, J. M. (1995) · Brain Research · doi:10.1016/0006-8993(95)00092-5 · Cited by 48 · see citing works
Self-citationA decreased tubular uptake of dopa results in defective renal dopamine production in aged rats
Armando, I., Nowicki, S., Aguirre, J., & Barontini, M. (1995) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1995.268.6.f1087 · Cited by 39 · see citing works
Self-citationPeptide regulation of adrenal medullary function
Livett, B. G., Marley, P. D., Wan, D. C., & Xin-fu, Z. (1990) · Springer eBooks · doi:10.1007/978-3-7091-9050-0_9 · Cited by 38 · see citing works
Polidori, C., Ciccocioppo, R., Nisato, D., Cazaubon, C., & Massi, M. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00329-x · Cited by 37 · see citing works
Increased AT1receptor expression and mRNA in kidney glomeruli of AT2receptor gene-disrupted mice
Saavedra, J. M., Häuser, W., Ciuffo, G. M., Egidy, G., Hoe, K., Jöhren, O., Sembonmatsu, T., Inagami, T., & Armando, I. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.280.1.f71 · Cited by 32 · see citing works
Self-citationGigante, B., Rubattu, S., Russo, R., Porcellini, A., Enea, I., Paolis, P. D., Savoia, C., Natale, A., Piras, O., & Volpe, M. (1997) · Hypertension · doi:10.1161/01.hyp.30.3.563 · Cited by 30 · see citing works
Moore, K. E. (1968) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y68-080 · Cited by 28 · see citing works
Interaction between CRF and angiotensin II in control of ACTH and adrenal steroids
KELLER-WOOD, M. E., Kimura, B., Shinsako, J., & Phillips, M. I. (1986) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1986.250.3.r396 · Cited by 23 · see citing works
Sever, P. S. (1999) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1000756 · Cited by 18 · see citing works
Moriuchi, R., Shibata, S., Himeno, A., Jöhren, O., Hoe, K., & Saavedra, J. M. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00187-9 · Cited by 16 · see citing works
Self-citationHorie, R., Yamori, Y., Nara, Y., Sawamura, M., & Mizushima, S. (1991) · Clinical and Experimental Hypertension · doi:10.3109/10641969109042090 · Cited by 8 · see citing works
Gerstberger, R., Paolo, T. D., & Barden, N. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90364-8 · Cited by 5 · see citing works
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Saavedra, J. M. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-005-4011-5 · Cited by 281 · see citing works
Self-citationNeural mechanisms of social homeostasis
Matthews, G. A., & Tye, K. M. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14016 · Cited by 273 · see citing works
Saavedra, J. M., Sánchez-Lemus, E., & Benický, J. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.10.001 · Cited by 260 · see citing works
Self-citationAngiotensin II AT1 receptor blockers as treatments for inflammatory brain disorders
Saavedra, J. M. (2012) · Clinical Science · doi:10.1042/cs20120078 · Cited by 219 · see citing works
Self-citationAndo, H., Zhou, J., Macova, M., Imboden, H., & Saavedra, J. M. (2004) · Stroke · doi:10.1161/01.str.0000129788.26346.18 · Cited by 181 · see citing works
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Saavedra, J. M., & Benický, J. (2007) · Stress · doi:10.1080/10253890701350735 · Cited by 166 · see citing works
Self-citationDRONJAK, S., GAVRILOVI, L., FILIPOVI, D., & RADOJI, M. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.01.011 · Cited by 142 · see citing works
Bregonzio, C., Armando, I., Ando, H., JEZOVA, M., Baiardi, G., & Saavedra, J. M. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00058.2003 · Cited by 129 · see citing works
Self-citationAnti-Inflammatory Effects of Angiotensin Receptor Blockers in the Brain and the Periphery
Benický, J., Sánchez-Lemus, E., Pavel, J., & Saavedra, J. M. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9368-4 · Cited by 126 · see citing works
Self-citationZórad, Š., Dou, J., Benický, J., Hutanu, D., Tybitanclová, K., Zhou, J., & Saavedra, J. M. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.08.062 · Cited by 125 · see citing works
Self-citationAnti-stress and anti-anxiety effects of centrally acting angiotensin II AT1 receptor antagonists
Saavedra, J. M., Ando, H., Armando, I., Baiardi, G., Bregonzio, C., Juorio, A. V., & Macova, M. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2004.12.015 · Cited by 119 · see citing works
Self-citationAngiotensin type 1 receptor inhibition enhances the extinction of fear memory
Marvar, P. J., Goodman, J., Fuchs, S., Choi, D. C., Banerjee, S., & Ressler, K. J. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.08.024 · Cited by 110 · see citing works
Saavedra, J. M., Armando, I., Bregonzio, C., Juorio, A. V., Macova, M., Pavel, J., & Sánchez-Lemus, E. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300921 · Cited by 109 · see citing works
Self-citationCentral Angiotensin II Stimulation Promotes β Amyloid Production in Sprague Dawley Rats
Zhu, D., Shi, J., Zhang, Y., Wang, B., Liu, W., Chen, Z., & Tong, Q. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016037 · Cited by 107 · see citing works
Wang, J., Pang, T., Hafko, R., Benický, J., Sánchez-Lemus, E., & Saavedra, J. M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.11.022 · Cited by 107 · see citing works
Self-citationSaavedra, J. M. (2011) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9754-6 · Cited by 91 · see citing works
Self-citationAdrenocortical dysregulation as a major player in insulin resistance and onset of obesity
Roberge, C., Carpentier, A. C., Langlois, M., Baillargeon, J., Ardilouze, J., Maheux, P., & Gallo‐Payet, N. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00516.2007 · Cited by 87 · see citing works
Armando, I., Volpi, S., Aguilera, G., & Saavedra, J. M. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.037 · Cited by 86 · see citing works
Self-citationBrain Angiotensin II, an Important Stress Hormone: Regulatory Sites and Therapeutic Opportunities
Saavedra, J. M., Ando, H., Armando, I., Baiardi, G., Bregonzio, C., JEZOVA, M., & Zhou, J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.009 · Cited by 84 · see citing works
Self-citationBali, A., & Jaggi, A. S. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.07.004 · Cited by 78 · see citing works
Zhou, F., Geng, Y., Xin, F., Li, J., Feng, P., Liu, C., Zhao, W., Feng, T., Guastella, A. J., Ebstein, R. P., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.007 · Cited by 69 · see citing works
Shekhar, A., Johnson, P. L., Sajdyk, T. J., Fitz, S. D., Keim, S. R., Kelley, P. E., Gehlert, D. R., & DiMicco, J. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2491-06.2006 · Cited by 77 · see citing works
Leong, D. S., Terrón, J. A., Falcón‐Neri, A., Armando, I., Ito, T., Jöhren, O., Tonelli, L. H., Hoe, K., & Saavedra, J. M. (2002) · Neuroendocrinology · doi:10.1159/000054714 · Cited by 77 · see citing works
Self-citationMacova, M., Armando, I., Zhou, J., Baiardi, G., Tyurmin, D., Larrayoz-Roldan, I. M., & Saavedra, J. M. (2008) · Neuroendocrinology · doi:10.1159/000150977 · Cited by 75 · see citing works
Self-citationPeripherally Administered Angiotensin II AT1 Receptor Antagonists Are Anti‐stress Compounds in Vivo
Pavel, J., Benický, J., Murakami, Y., Sánchez-Lemus, E., & Saavedra, J. M. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.006 · Cited by 74 · see citing works
Self-citationPavlatou, M. G., Mastorakos, G., Lekakis, I., Liatis, S., Vamvakou, G., Zoumakis, E., Papassotiriou, I., Rabavilas, A. D., Katsilambros, N., & Chrousos, G. P. (2008) · Stress · doi:10.1080/10253890701476621 · Cited by 66 · see citing works
Seltzer, A. M., Bregonzio, C., Armando, I., Baiardi, G., & Saavedra, J. M. (2004) · Brain Research · doi:10.1016/j.brainres.2004.06.079 · Cited by 63 · see citing works
Self-citationBrain renin-angiotensin system in the pathophysiology of cardiovascular diseases
Huber, G., Schuster, F., & Raasch, W. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.06.016 · Cited by 62 · see citing works
Liebl, C. (2009) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.001.2009 · Cited by 60 · see citing works
Häfner, S., Baumert, J., Emeny, R. T., Lacruz, M. E., Bidlingmaier, M., Reincke, M., Kuenzel, H., Holle, R., Rupprecht, R., & Ladwig, K. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.06.007 · Cited by 54 · see citing works
Bregonzio, C., Seltzer, A. M., Armando, I., Pavel, J., & Saavedra, J. M. (2008) · Stress · doi:10.1080/10253890801892040 · Cited by 53 · see citing works
Self-citationRaasch, W., Wittmershaus, C., Dendorfer, A., Voges, I., Pahlke, F., Dodt, C., Dominiak, P., & Jöhren, O. (2006) · Endocrinology · doi:10.1210/en.2006-0198 · Cited by 52 · see citing works
Renal dopaminergic defect in C57Bl/6J mice
Escano, C. S., Armando, I., Wang, X., Asico, L. D., Pascua, A., Yang, Y., Wang, Z., Lau, Y., & José, P. A. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00147.2009 · Cited by 53 · see citing works
Self-citationAlmeida-Santos, A. F., Kangussu, L. M., Moreira, F. A., Santos, R. A. S., de Aguiar, D. C., & Campagnole‐Santos, M. J. (2016) · Clinical Science · doi:10.1042/cs20160116 · Cited by 51 · see citing works
Diniz, C. R. A. F., Casarotto, P. C., Fred, S. M., Biojone, C., Ċastrén, E., & Joca, S. R. L. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.03.011 · Cited by 50 · see citing works
Sánchez-Lemus, E., Murakami, Y., Larráyoz, I. M., Moughamian, A. J., Pavel, J., Nishioku, T., & Saavedra, J. M. (2008) · Endocrinology · doi:10.1210/en.2008-0242 · Cited by 50 · see citing works
Self-citationÜresin, Y., Erbaş, B., Özek, M., Özkök, E., & Gürol, A. O. (2004) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.3317/jraas.2004.017 · Cited by 49 · see citing works
Renin-Angiotensin System Hyperactivation Can Induce Inflammation and Retinal Neural Dysfunction
Kurihara, T., Ozawa, Y., Ishida, S., Okano, H., & Tsubota, K. (2012) · International Journal of Inflammation · doi:10.1155/2012/581695 · Cited by 48 · see citing works
Gryksa, K., & Neumann, I. D. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105601 · Cited by 49 · see citing works
Chen, D., Jancovski, N., Bassi, J. K., Nguyen‐Huu, T., Choong, Y., Palma‐Rigo, K., Davern, P. J., Gurley, S. B., Thomas, W. G., Head, G. A., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5360-11.2012 · Cited by 46 · see citing works
Pulcu, E., Shkreli, L., Holst, C. G., Woud, M., Craske, M., Browning, M., & Reinecke, A. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.010 · Cited by 41 · see citing works
Angiotensin II: multitasking in the brain
Saavedra, J. M., Benický, J., & Zhou, J. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000220418.09021.ee · Cited by 46 · see citing works
Self-citationJEZOVA, M., Armando, I., Bregonzio, C., Yu, Z., Qian, S., Ferrans, V. J., Imboden, H., & Saavedra, J. M. (2003) · Endocrinology · doi:10.1210/en.2002-0019 · Cited by 45 · see citing works
Self-citationWang, L. A., de Kloet, A. D., Smeltzer, M. D., Cahill, K. M., Hiller, H., Bruce, E. B., Pioquinto, D. J., Ludin, J. A., Katovich, M. J., Raizada, M. K., et al. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.025 · Cited by 43 · see citing works
Sánchez-Lemus, E., Benický, J., Pavel, J., & Saavedra, J. M. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.04.012 · Cited by 43 · see citing works
Self-citationThe role of the brain renin-angiotensin system (RAS) in mild traumatic brain injury (TBI)
Vadhan, J. D., & Speth, R. C. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107684 · Cited by 42 · see citing works
Brain angiotensin-(1–7)/Mas axis: A new target to reduce the cardiovascular risk to emotional stress
Fontes, M. A. P., Lima, A. M., & Santos, R. A. S. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.10.003 · Cited by 41 · see citing works
Terock, J., Hannemann, A., Janowitz, D., Freyberger, H. J., Felix, S. B., Dörr, M., Nauck, M. A., Völzke, H., & Grabe, H. J. (2018) · Psychological Medicine · doi:10.1017/s0033291718001496 · Cited by 40 · see citing works
Angiotensin Regulation of Amygdala Response to Threat in High-Trait-Anxiety Individuals.
Reinecke, A., Browning, M., Breteler, J. K., Kappelmann, N., Ressler, K., Harmer, C., & Craske, M. (2018) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.05.007 · Cited by 35 · see citing works
Armando, I., JEZOVA, M., Bregonzio, C., Baiardi, G., & Saavedra, J. M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.036 · Cited by 38 · see citing works
Self-citationAngiotensin Receptor Blockers Are Not Just for Hypertension Anymore
Saavedra, J. M. (2021) · Physiology · doi:10.1152/physiol.00036.2020 · Cited by 37 · see citing works
Self-citationNormal Physiology of ACTH and GH Release in the Hypothalamus and Anterior Pituitary in Man
Lim, C. T., & Khoo, B. C. E. (2014) · Cited by 36 · see citing works
Macova, M., Pavel, J., & Saavedra, J. M. (2008) · Brain Research · doi:10.1016/j.brainres.2008.11.006 · Cited by 36 · see citing works
Self-citationAssociation between a functional polymorphism in the renin-angiotensin system and completed suicide
Hishimoto, A., Shirakawa, O., Nishiguchi, N., Hashimoto, T., Yanagi, M., Nushida, H., Ueno, Y., & Maeda, K. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0483-9 · Cited by 36 · see citing works
Secretin: Hypothalamic Distribution and Hypothesized Neuroregulatory Role in Autism
Welch, M. G., Keune, J. D., Welch-Horan, T. B., Anwar, N., Anwar, M., Ludwig, R. J., & Ruggiero, D. A. (2004) · Cellular and Molecular Neurobiology · doi:10.1023/b:cemn.0000018618.59015.a2 · Cited by 35 · see citing works
Armando, I., Terrón, J. A., Falcón‐Neri, A., Takeshi, I., Häuser, W., Inagami, T., & Saavedra, J. M. (2002) · Neuroendocrinology · doi:10.1159/000064525 · Cited by 35 · see citing works
Self-citationWincewicz, D., Juchniewicz, A., Waszkiewicz, N., & Braszko, J. J. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.06.010 · Cited by 34 · see citing works
Gong, S., & Deng, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1053136 · Cited by 35 · see citing works
Candesartan prevents impairment of recall caused by repeated stress in rats
Braszko, J. J., Wincewicz, D., & Jakubów, P. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2829-3 · Cited by 32 · see citing works
Transient hypertension and sustained tachycardia in mice housed individually in metabolism cages
Hoppe, C., Moritz, K. M., Fitzgerald, S. M., Bertram, J. F., & Evans, R. G. (2009) · Physiological Research · doi:10.33549/physiolres.931390 · Cited by 32 · see citing works
Tchekalarova, J. D., Loyens, E., & Smolders, I. J. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2015.03.021 · Cited by 31 · see citing works
Angiotensin II-triggered kinase signaling cascade in the central nervous system
Bali, A., & Jaggi, A. S. (2015) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0041 · Cited by 30 · see citing works
Donadio, M. V. F., Kunrath, A., Corezola, K. L., Franci, C. R., Anselmo-Franci, J. A., Lucion, A. B., & Sanvitto, G. L. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.05.005 · Cited by 29 · see citing works
Involvement of the Renin-Angiotensin System in Stress: State of the Art and Research Perspectives
Correa, B. H. M., Becari, L., Fontes, M. A. P., Silva, A. C. S. E., & Kangussu, L. M. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210719142300 · Cited by 28 · see citing works
Angiotensin II AT1 Receptor Blockade Prevents Gastric Ulcers during Cold‐Restraint Stress
Bregonzio, C., Armando, I., Ando, H., JEZOVA, M., Baiardi, G., & Saavedra, J. M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.044 · Cited by 28 · see citing works
Self-citationBalthazar, L., Lages, Y., Romano, V. C., Landeira-Fernández, J., & Krahe, T. E. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105354 · Cited by 27 · see citing works
Regulation of the hypothalamic-pituitary-adrenal axis by neuropeptides
Aguilera, G. (2011) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2011.123 · Cited by 27 · see citing works
Cudnoch‐Jędrzejewska, A., Dobruch, J. T., Puchalska, L., & Szczepanska‐Sadowska, E. K. (2007) · Regulatory Peptides · doi:10.1016/j.regpep.2007.01.010 · Cited by 26 · see citing works
Tjurmina, O., Armando, I., Saavedra, J. M., Li, Q., & Murphy, D. L. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.011 · Cited by 26 · see citing works
Self-citationSommer, W. H., & Saavedra, J. M. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0333-3 · Cited by 26 · see citing works
Self-citationSzczepanska‐Sadowska, E. K., Wsół, A., Cudnoch‐Jędrzejewska, A., Czarzasta, K., & Żera, T. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11040908 · Cited by 26 · see citing works
Mayorov, D. N. (2010) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2010.05469.x · Cited by 25 · see citing works
Baiardi, G., Bregonzio, C., JEZOVA, M., Armando, I., & Saavedra, J. M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.015 · Cited by 24 · see citing works
Self-citationAndo, H., JEZOVA, M., Zhou, J., & Saavedra, J. M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.043 · Cited by 22 · see citing works
Self-citationArmando, I., Tjurmina, O., Li, Q., Murphy, D. L., & Saavedra, J. M. (2003) · Neuroendocrinology · doi:10.1159/000073705 · Cited by 22 · see citing works
Self-citationSaavedra, J. M., & Armando, I. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0533-x · Cited by 21 · see citing works
Self-citationKoyama, Y., Mukuda, T., Hamasaki, S., Nakane, H., & Kaidoh, T. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.045 · Cited by 21 · see citing works
Erdös, B., Broxson, C. S., Landa, T., Scarpace, P. J., Leeuwenburgh, C., Zhang, Y., & Tümer, N. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.04.007 · Cited by 21 · see citing works
Xu, T., Zhou, X., Jiao, G., Zeng, Y., Zhao, W., Li, J., Yu, F., Zhou, F., Yao, S., & Becker, B. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.05.007 · Cited by 20 · see citing works
Sánchez-Lemus, E., Honda, M., & Saavedra, J. M. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.03.041 · Cited by 20 · see citing works
Self-citationStress sensitivity is increased in transgenic rats with low brain angiotensinogen
Müller‐Fielitz, H., Kröger, J., Jöhren, O., Szymczak, S., Bäder, M., Dominiak, P., & Raasch, W. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0363 · Cited by 20 · see citing works
Systemic angiotensin II and exercise-induced neurogenesis in adult rat hippocampus
Mukuda, T., Koyama, Y., Hamasaki, S., Kaidoh, T., & Furukawa, Y. (2014) · Brain Research · doi:10.1016/j.brainres.2014.09.019 · Cited by 18 · see citing works
Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats
Rodríguez, R., Minas, J. N., Vázquez‐Medina, J. P., Nakano, D., Parkes, D. G., Nishiyama, A., & Ortiz, R. M. (2018) · Journal of Endocrinology · doi:10.1530/joe-17-0678 · Cited by 18 · see citing works
Afzal, S., Sattar, M. Z. A., Johns, E. J., Abdulla, M. H., Akhtar, S., Hashmi, F., & Abdullah, N. A. (2016) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-016-0497-1 · Cited by 16 · see citing works
Saavedra, J. M., & Pavel, J. (2005) · Drug Development Research · doi:10.1002/ddr.20027 · Cited by 16 · see citing works
Self-citationKumar, K. A., Nagwar, S., Thyloor, R., & Satyanarayana, S. (2014) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320313516173 · Cited by 16 · see citing works
Wincewicz, D., & Braszko, J. J. (2017) · Pharmacopsychiatry · doi:10.1055/s-0043-112345 · Cited by 16 · see citing works
Welch, M. G., & Ruggiero, D. A. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)71012-6 · Cited by 16 · see citing works
Tashev, R. E., & Velikova, M. (2018) · Pharmacological Reports · doi:10.1016/j.pharep.2018.03.001 · Cited by 15 · see citing works
Altered urinary excretion of aquaporin 2 in IgA nephropathy
Rocchetti, M. T., Tamma, G., Lasorsa, D. R., Suriano, I. V., d’Apollo, A. M., Papale, M., Mastrofrancesco, L., Grandaliano, G., Svelto, M., Valenti, G., et al. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0512 · Cited by 15 · see citing works
Erdös, B., Clifton, R. R., Liu, M., Li, H., McCowan, M. L., Sumners, C., & Scheuer, D. A. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00207.2015 · Cited by 14 · see citing works
QTL mapping for traits associated with stress neuroendocrine reactivity in rats
Llamas, B., Contesse, V., Guyonnet‐Dupérat, V., Vaudry, H., Mormède, P., & Moisan, M. (2005) · Mammalian Genome · doi:10.1007/s00335-005-0022-2 · Cited by 14 · see citing works
Cecconello, A. L., Raineki, C., Sebben, V., Lucion, A. B., & Sanvitto, G. L. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.10.026 · Cited by 13 · see citing works
Nostramo, R., Tillinger, A., Saavedra, J. M., Kumar, A., Pandey, V. G., Serova, L. I., Květňanský, R., & Sabban, E. L. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0181 · Cited by 12 · see citing works
Self-citationBrasil, T. F. S., Fassini, A., & Corrêa, F. M. D. A. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0518-9 · Cited by 12 · see citing works
Silva, C. C., Correa, A. M., Kushmerick, C., Sharma, N. M., Patel, K. P., Almeida, J. F., Moreira, F. A., Ferreira, A. J., & Fontes, M. A. P. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102076 · Cited by 12 · see citing works
Song, Y., Fan, H., Tang, X., Luo, Y., Liu, P., & Chen, Y. (2021) · International Journal of Neuroscience · doi:10.1080/00207454.2021.1897588 · Cited by 11 · see citing works
Terock, J., Hannemann, A., Janowitz, D., Völzke, H., Nauck, M. A., Freyberger, H.-J., Wallaschofski, H., & Grabe, H. J. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.03.007 · Cited by 11 · see citing works
Afzal, S., Sattar, M. Z. A., Johns, E. J., & Eseyin, O. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229803 · Cited by 11 · see citing works
Aldosterone Action on Brain and Behavior
Murck, H. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00052-3 · Cited by 10 · see citing works
- Authors
- Armando, I., Carranza, A., Nishimura, Y., Hoe, K.-L., Barontini, M., Terrón, J. A., Falcón-Neri, A., Ito, T., Juorio, A. V., & Saavedra, J. M.
- Affiliations
- Centro de Investigaciones Endocrinologicas, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires (I.A., A.C., M.B.), Buenos Aires 1013, Argentina
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- National Institutes of Health (US)
- Section on Pharmacology, National Institute of Mental Health, National Institutes of Health (I.A., Y.N., K.-L.H., J.A.T., A.F.-N., T.I., A.V.J., J.M.S.), Bethesda, Maryland 20814
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2001-09-01
- Volume
- 142
- Issue
- 9
- Pages
- 3880-3889
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W1985671788
- Cited by
- 148
- References
- 50
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 9 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 7 · 2016: 5 · 2015: 8 · 2014: 3 · 2013: 6 · 2012: 7
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- angiotensin II, AT1 receptor antagonists, candesartan, isolation stress, hypothalamic-pituitary-adrenal axis, paraventricular nucleus, ACTH, vasopressin, aldosterone, corticosterone, adrenal catecholamines, angiotensin II type 2 receptor, zona glomerulosa, stress response
- MeSH terms
- Adrenal Cortex Hormones, Adrenal Glands, Animals, Benzimidazoles, Biphenyl Compounds, Brain, Catecholamines, Hormones, Hypothalamo-Hypophyseal System, Infusion Pumps, Injections, Subcutaneous, Male, Pituitary Hormones, Pituitary-Adrenal System, Receptors, Angiotensin, RNA, Messenger, Social Isolation, Stress, Psychological, Tetrazoles, Tyrosine 3-Monooxygenase, Rats, Wistar, Receptor, Angiotensin, Type 2, Receptor, Angiotensin, Type 1, Rats, Angiotensin Receptor Antagonists
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