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Cited by 1,537

The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.

Aromatase Cytochrome P450, The Enzyme Responsible for Estrogen Biosynthesis*

SIMPSON, EVAN R., MAHENDROO, MALA S., MEANS, GARY D., KILGORE, MICHAEL W., HINSHELWOOD, MARGARET M., GRAHAM-LORENCE, SANDRA, AMARNEH, BILAL, ITO, YUJI, FISHER, CAROLYN R., MICHAEL, M. DODSON, MENDELSON, CAROLE R., BULUN, SERDAR E.·1994·Endocrine Reviews
DOI 10.1210/edrv-15-3-342
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Abstract

THE biosynthesis of estrogens appears to occur throughout the entire vertebrate phylum including mammals, birds, reptiles, amphibians, teleost and elasmobranch fish, and Agnatha (hagfish and lampreys) (1–3). It has also been described in the protochordate Amphioxus (4). To our knowledge, estrogen biosynthesis has not been reported in nonvertebrate animal phyla. In most vertebrate species that have been examined, aromatase expression occurs in the gonads and in the brain. This is true of the fish and avian species that have been examined as well as most mammals such as rodents. In many species estrogen biosynthesis in the brain has been implicated in sex-related behavior such as mating responses, and frequently a marked sexually dimorphic difference has been demonstrated. This is true, for example, in avian species in which the song of the male is important in courtship behavior (5). In the case of humans and a number of higher primates, there is a more extensive tissue distribution of estrogen biosynthesis, since this also occurs in the placenta of the developing fetus as well as in the adipose tissue of the adult.

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Metadata

Authors
SIMPSON, E. R., MAHENDROO, M. S., MEANS, G. D., KILGORE, M. W., HINSHELWOOD, M. M., GRAHAM-LORENCE, S., AMARNEH, B., ITO, Y., FISHER, C. R., MICHAEL, M. D., MENDELSON, C. R., & BULUN, S. E.
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
1994-06
Volume
15
Issue
3
Pages
342-355
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/edrv-15-3-342
OpenAlex
W2099423538
Cited by
1,537
References
75
FWCI
16.33
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Aromatase Cytochrome P450, The Enzyme Responsible for Estrogen Biosynthesis*. https://app.cochat.ai/papers/10.1210/edrv-15-3-342
The paper
SIMPSON, E. R., MAHENDROO, M. S., MEANS, G. D., KILGORE, M. W., HINSHELWOOD, M. M., GRAHAM-LORENCE, S., AMARNEH, B., ITO, Y., FISHER, C. R., MICHAEL, M. D., MENDELSON, C. R., & BULUN, S. E. (1994). Aromatase Cytochrome P450, The Enzyme Responsible for Estrogen Biosynthesis*. Endocrine Reviews. https://doi.org/10.1210/edrv-15-3-342

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.