The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Mechanism of the Stimulatory Effect of Growth Hormone on Longitudinal Bone Growth*
Abstract
AT THE beginning of this century Aschner (1) demonstrated a relationship between a factor in the pituitary and body growth. In subsequent experiments Evans and Long (2) produced supranormal growth in intact rats with administration of bovine pituitary extracts. In the 1940s a highly purified protein was isolated from bovine pituitaries (3, 4) that produced somatic growth when administered to hypophysectomized or normal rats. This protein exhibited no or small effects on the gonads and the thyroid gland and was called GH or somatotropin. The molecular structure of GH was not revealed until the beginning of the 1970s when the total amino acid sequence of GH was determined (5, 6). As early as 1923 Dott and Fraser (7) observed a decrease in epiphyseal cartilage width in cats and dogs after hypophysectomy. Dott (8) also found that treatment with extracts from the anterior pituitary lobe partially reversed this effect. Freud and co-workers (9) found that GH increased the nose-tail length in hypophysectomized rats by increasing the thickness of growth zones in the tail vertebrae, suggesting that GH increases the thickness of the growth plate by stimulating the proliferation of chondrocytes.
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Cites
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Actions of Insulin-Like Growth Factors
Froesch, E. R., Schmid, C., Schwander, J., & Zapf, J. (1985) · Annual Review of Physiology · doi:10.1146/annurev.ph.47.030185.002303 · Cited by 1,153
A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro.
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Somatomedin: Proposed Designation for Sulphation Factor
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Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells
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Primary structure of human insulin‐like growth factor II
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Insulin-like growth factor I stimulates growth in hypophysectomized rats
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Cited by
The Somatomedin Hypothesis: 2001
Le Roith, D., Bondy, C., Yakar, S., Liu, J.-L., & Butler, A. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.1.0419 · Cited by 1,257
Woods, K. A., Camacho-Hübner, C., Savage, M. O., & Clark, A. J. L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610313351805 · Cited by 1,085
Sjögren, K., Liu, J.-L., Blad, K., Skrtic, S., Vidal, O., Wallenius, V., LeRoith, D., Törnell, J., Isaksson, O. G. P., Jansson, J.-O., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.7088 · Cited by 938
Self-citationHuman growth hormone and human aging
CORPAS, E., HARMAN, S. M., & BLACKMAN, M. R. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-1-20 · Cited by 911
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Self-citation
Metadata
- Authors
- ISAKSSON, O. G. P., LINDAHL, A., NILSSON, A., & ISGAARD, J.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 1987-11
- Volume
- 8
- Issue
- 4
- Pages
- 426-438
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2024394264
- Cited by
- 580
- References
- 57
- FWCI
- 11.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- ISAKSSON, O. G. P., LINDAHL, A., NILSSON, A., & ISGAARD, J. (1987). Mechanism of the Stimulatory Effect of Growth Hormone on Longitudinal Bone Growth*. Endocrine Reviews. https://doi.org/10.1210/edrv-8-4-426
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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