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Minireview: Tissue-Specific Versus Generalized Gene Targeting of the igf1 and igf1r Genes and Their Roles in Insulin-Like Growth Factor Physiology
Abstract
The insulin-like growth factors (IGF-I and IGF-II) and the IGF-I receptor are critically important for normal growth and development of the organism. Gene-deletion of these elements has demonstrated that IGF-I is important for both prenatal and postnatal development, whereas IGF-II is important during prenatal stages only. The IGF-I receptor gene-deleted mouse dies at birth apparently as a result of poor muscular development. Utilizing the conditional gene-deletion approach, we have demonstrated that mice lacking the liver IGF-I gene have an approximately 80% reduction in circulating total IGF-I levels. Despite this marked reduction, postnatal growth and development was normal, suggesting that liver IGF-I is not essential for this function. Local tissue IGF-I production was unaffected and may compensate for the lack of the liver IGF-I. Further studies are ongoing to establish the role of the endocrine vs. the autocrine/paracrine IGF-I.
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Cited by
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326
Endocrine Regulation of the Growth Plate
Nilsson, O., Marino, R., De Luca, F., Phillip, M., & Baron, J. (2005) · Hormone Research in Paediatrics · doi:10.1159/000088791 · Cited by 441
Chemistry and Biochemistry of Type 2 Diabetes
Ross, S. A., Gulve, E. A., & Wang, M. (2004) · Chemical Reviews · doi:10.1021/cr0204653 · Cited by 323
López-Márquez, A., Carrasco-López, C., Fernández-Méndez, C., & Santisteban, P. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.654569 · Cited by 49
Yang, S., Wu, B., Sun, H., Sun, T., Han, K., Li, D., Ji, F., Zhang, G., & Zhou, D. (2017) · Bioscience Reports · doi:10.1042/bsr20170776 · Cited by 23
Metadata
- Authors
- Butler, A. A.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2001-05-01
- Volume
- 142
- Issue
- 5
- Pages
- 1685-1688
- ISSN
- 0013-7227 (ISSN-L)
- OpenAlex
- W2020936520
- Cited by
- 211
- References
- 0
- FWCI
- 11.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Minireview: Tissue-Specific Versus Generalized Gene Targeting of the igf1 and igf1r Genes and Their Roles in Insulin-Like Growth Factor Physiology. https://app.cochat.ai/papers/10.1210/en.142.5.1685
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- Butler, A. A. (2001). Minireview: Tissue-Specific Versus Generalized Gene Targeting of the igf1 and igf1r Genes and Their Roles in Insulin-Like Growth Factor Physiology. Endocrinology. https://doi.org/10.1210/en.142.5.1685
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