The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Endocrine Regulation of the Growth Plate
Abstract
Longitudinal bone growth occurs at the growth plate by endochondral ossification. Within the growth plate, chondrocyte proliferation, hypertrophy, and cartilage matrix secretion result in chondrogenesis. The newly formed cartilage is invaded by blood vessels and bone cells that remodel the newly formed cartilage into bone tissue. This process of longitudinal bone growth is governed by a complex network of endocrine signals, including growth hormone, insulin-like growth factor I, glucocorticoid, thyroid hormone, estrogen, androgen, vitamin D, and leptin. Many of these signals regulate growth plate function, both by acting locally on growth plate chondrocytes and also indirectly by modulating other endocrine signals in the network. Some of the local effects of hormones are mediated by changes in paracrine factors that control chondrocyte proliferation and differentiation. Many human skeletal growth disorders are caused by abnormalities in the endocrine regulation of the growth plate. This review provides an overview of the endocrine signals that regulate longitudinal bone growth, their interactions, and the mechanisms by which they affect growth plate chondrogenesis.
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Cites
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Cited by
Nutrition in adolescent growth and development
Norris, S. A., Frongillo, E. A., Black, M. M., Dong, Y., Fall, C., Lampl, M., Liese, A. D., Naguib, M., Prentice, A., Rochat, T., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)01590-7 · Cited by 518
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Thompson, E. M., Matsiko, A., Farrell, E., Kelly, D. J., & O'Brien, F. J. (2015) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1918 · Cited by 147
Metadata
- Authors
- Nilsson, O., Marino, R., De Luca, F., Phillip, M., & Baron, J.
- Venue
- Hormone Research in Paediatrics
- Publisher
- S. Karger AG
- Published
- 2005
- Volume
- 64
- Issue
- 4
- Pages
- 157-165
- ISSN
- 1663-2818 (ISSN-L)
- 1663-2826
- OpenAlex
- W2074611556
- Cited by
- 441
- References
- 80
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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