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Neuropeptide Y has a central inhibitory action on the hypothalamic-pituitary-thyroid axis
Abstract
Recent evidence suggests that neuropeptide Y (NPY), originating in neurons in the hypothalamic arcuate nucleus, is an important mediator of the effects of leptin on the central nervous system. As these NPY neurons innervate hypophysiotropic neurons in the hypothalamic paraventricular nucleus (PVN) that produce the tripeptide, TRH, we raised the possibility that NPY may be responsible for resetting of the hypothalamic-pituitary-thyroid (HPT) axis during fasting. To test this hypothesis, the effects of intracerebroventricularly administered NPY on circulating thyroid hormone levels and proTRH messenger RNA in the PVN were studied by RIA and in situ hybridization histochemistry, respectively. NPY administration suppressed circulating levels of thyroid hormone (T(3) and T(4)) and resulted in an inappropriately normal or low TSH. These alterations were associated with a significant suppression of proTRH messenger RNA in the PVN, indicating that NPY infusion had resulted in a state of central hypothyroidism. Similar observations were made in NPY-infused animals pair fed to the vehicle-treated controls. These data are reminiscent of the effect of fasting on the thyroid axis and indicate that NPY may play a major role in the inhibition of HPT axis during fasting.
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“central administration of NPY or AGRP to fed animals induces a state of central hypothyroidism similar to that observed in fasted animals (Figure 14), despite that the animals markedly increase their food intake secondary to the potent orexigenic effect of these peptides (152, 154, 155)”
From Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions (2014) · cites this paper as [154]
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References 53 · Cited by 167
Research works printed but not linked: 2
- Peters, 1991, Neurons and Their Supporting Cells
- Lechan, 1993, Update on thyrotropin-releasing hormone., Thyroid Today, 16, 1
Metadata
- Authors
- Fekete, C., Kelly, J., Mihály, E., Sarkar, S., Rand, W. M., Légrádi, G., Emerson, C. H., & Lechan, R. M.
- Affiliations
- Tufts Medical Center (US)
- Tupper Research Institute and Department of Medicine (C.F., J.K., E.M., S.S., G.L., R.M.L.), Division of Endocrinology, Diabetes, Metabolism and Molecular Medicine, New England Medical Center, Boston, Massachusetts 02111
- Tufts University (US)
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Lechan, Ronald M.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2001-06-01
- Volume
- 142
- Issue
- 6
- Pages
- 2606-2613
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W1993563186
- Cited by
- 167
- References
- 53
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 1 · 2020: 2 · 2018: 3 · 2017: 9 · 2016: 6 · 2015: 1 · 2014: 7 · 2013: 6 · 2012: 11
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA 10732, R01DA010732)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 37021)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- neuropeptide Y, hypothalamic-pituitary-thyroid axis, paraventricular nucleus, thyrotropin-releasing hormone, thyroid hormone suppression, central hypothyroidism, fasting, leptin, arcuate nucleus, thyroid-stimulating hormone
- MeSH terms
- Adipose Tissue, Animals, Arcuate Nucleus of Hypothalamus, Autoradiography, Body Weight, Brain, Adipose Tissue, Brown, Eating, Epididymis, Hypothalamus, Male, Neuropeptide Y, Organ Size, Pituitary Gland, Protein Precursors, RNA, Messenger, Thyroid Gland, Thyrotropin, Thyroxine, Triiodothyronine, Rats, Sprague-Dawley, In Situ Hybridization, Leptin, Rats
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- The paper
- Fekete, C., Kelly, J., Mihály, E., Sarkar, S., Rand, W. M., Légrádi, G., Emerson, C. H., & Lechan, R. M. (2001). Neuropeptide Y has a central inhibitory action on the hypothalamic-pituitary-thyroid axis. Endocrinology. https://doi.org/10.1210/endo.142.6.8207
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
