Lechan, Ronald M.

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

Liu, J., Lichtenberg, T., Hoadley, K. A., Poisson, L. M., Lazar, A. J., Cherniack, A. D., Kovatich, A. J., Benz, C. C., Levine, D. A., Lee, A. V., et al. (2018) · Cell

Cancer Genomics and DiagnosticsGene expression and cancer classification

Cited by 3,725

Oncogenic Signaling Pathways in The Cancer Genome Atlas

Sanchez-Vega, F., Mina, M., Armenia, J., Chatila, W. K., Luna, A., La, K. C., Dimitriadoy, S., Liu, D. L., Kantheti, H. S., Saghafinia, S., et al. (2018) · Cell

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 3,201

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

Hoadley, K. A., Yau, C., Hinoue, T., Wolf, D. M., Lazar, A. J., Drill, E., Shen, R., Taylor, A. M., Cherniack, A. D., Thorsson, V., et al. (2018) · Cell

Cancer Genomics and DiagnosticsGene expression and cancer classification

Cited by 2,546

Comprehensive Characterization of Cancer Driver Genes and Mutations

Bailey, M. H., Tokheim, C., Porta-Pardo, E., Sengupta, S., Bertrand, D., Weerasinghe, A., Colaprico, A., Wendl, M. C., Kim, J., Reardon, B., et al. (2018) · Cell

Cancer Genomics and DiagnosticsGenomics and Rare Diseases

Cited by 2,256

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

Malta, T. M., Sokolov, A., Gentles, A. J., Burzykowski, T., Poisson, L., Weinstein, J. N., Kamińska, B., Huelsken, J., Omberg, L., Gevaert, O., et al. (2018) · Cell

Cancer Cells and MetastasisPluripotent Stem Cells Research

Cited by 2,180

Comprehensive Characterization of Cancer Driver Genes and Mutations

Bailey, M. H., Tokheim, C., Porta-Pardo, E., Sengupta, S., Bertrand, D., Weerasinghe, A., Colaprico, A., Wendl, M. C., Kim, J., Reardon, B., et al. (2018) · Cell

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 552

Leptin Prevents Fasting-Induced Suppression of Prothyrotropin-Releasing Hormone Messenger Ribonucleic Acid in Neurons of the Hypothalamic Paraventricular Nucleus*

Légrádi, G., Emerson, C. H., Ahima, R. S., Flier, J. S., & Lechan, R. M. (1997) · Endocrinology

Regulation of Appetite and ObesityThyroid Disorders and Treatments

Cited by 505

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

Wang, Y., Xu, X., Maglic, D., Dill, M. T., Mojumdar, K., Ng, P. K.-S., Jeong, K. J., Tsang, Y. H., Moreno, D., Bhavana, V. H., et al. (2018) · Cell Reports

Hippo pathway signaling and YAP/TAZCancer-related molecular mechanisms research

Cited by 500

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Schaub, F. X., Dhankani, V., Berger, A. C., Trivedi, M., Richardson, A. B., Shaw, R., Zhao, W., Zhang, X., Ventura, A., Liu, Y., et al. (2018) · Cell Systems

Cancer Genomics and DiagnosticsCancer-related Molecular Pathways

Cited by 431

Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

Ding, L., Bailey, M. H., Porta-Pardo, E., Thorsson, V., Colaprico, A., Bertrand, D., Gibbs, D. L., Weerasinghe, A., Huang, K.-L., Tokheim, C., et al. (2018) · Cell

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 399

Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions

Fekete, C., & Lechan, R. M. (2014) · Endocrine Reviews

Thyroid Disorders and TreatmentsHypothalamic control of reproductive hormones

Cited by 342

Immunoreactive interleukin-1β localization in the rat forebrain

Lechan, R. M., Toni, R., Clark, B. D., Cannon, J. G., Shaw, A. R., Dinarello, C. A., & Reichlin, S. (1990) · Brain Research

Neuroinflammation and Neurodegeneration MechanismsNeuropeptides and Animal Physiology

Cited by 340

The TRH neuron: a hypothalamic integrator of energy metabolism

Lechan, R. M., & Fekete, C. (2006) · Progress in brain research

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 338

Thyroid hormone regulates TRH biosynthesis in the paraventricular nucleus of the rat hypothalamus

Segerson, T. P., Kauer, J., Wolfe, H. C., Mobtaker, H., Wu, P., Jackson, I. M. D., & Lechan, R. M. (1987) · Science

Thyroid Disorders and TreatmentsHypothalamic control of reproductive hormones

Cited by 327

α-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression

Fekete, C., Légrádi, G., Mihály, E., Huang, Q.-H., Tatro, J. B., Rand, W. M., Emerson, C. H., & Lechan, R. M. (2000) · The Journal of Neuroscience

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 308

Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone

Tu, H. M., Kim, S.-W., Salvatore, D., Bartha, T., Legradi, G., Larsen, P. R., & Lechan, R. M. (1997) · Endocrinology

Thyroid Disorders and TreatmentsRegulation of Appetite and Obesity

Cited by 302

Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine

Werneck de Castro, J. P., Fonseca, T. L., Ueta, C. B., McAninch, E. A., Abdalla, S., Wittmann, G., Lechan, R. M., Gereben, B., & Bianco, A. C. (2015) · Journal of Clinical Investigation

Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and Treatment

Cited by 184

Lipopolysaccharide Induces Type 2 Iodothyronine Deiodinase in the Mediobasal Hypothalamus: Implications for the Nonthyroidal Illness Syndrome

Fekete, C., Gereben, B., Doleschall, M., Harney, J. W., Dora, J. M., Bianco, A. C., Sarkar, S., Liposits, Z., Rand, W., Emerson, C., et al. (2004) · Endocrinology

Thyroid Disorders and TreatmentsNeuropeptides and Animal Physiology

Cited by 179

Neuropeptide Y has a central inhibitory action on the hypothalamic-pituitary-thyroid axis

Fekete, C., Kelly, J., Mihály, E., Sarkar, S., Rand, W. M., Légrádi, G., Emerson, C. H., & Lechan, R. M. (2001) · Endocrinology

Neuropeptides and Animal PhysiologyThyroid Disorders and Treatments

Cited by 167

Association of cocaine- and amphetamine-regulated transcript-immunoreactive elements with thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and its role in the regulation of the hypothalamic-pituitary-thyroid axis during fasting

Fekete, C., Mihály, E., Luo, L.-G., Kelly, J., Clausen, J. T., Mao, Q., Rand, W. M., Moss, L. G., Kuhar, M., Emerson, C. H., et al. (2000) · The Journal of Neuroscience

Neuropeptides and Animal PhysiologyRegulation of Appetite and Obesity

Cited by 163

Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells

Freitas, B. C. G., Gereben, B., Castillo, M., Kalló, I., Zeöld, A., Egri, P., Liposits, Z., Zavacki, A. M., Maciel, R. M. B., Jo, S., et al. (2010) · Journal of Clinical Investigation

Thyroid Disorders and TreatmentsEstrogen and related hormone effects

Cited by 160

Coordination of hypothalamic and pituitary T3 production regulates TSH expression

Fonseca, T. L., Correa-Medina, M., Campos, M. P. O., Wittmann, G., Werneck-de-Castro, J. P., Arrojo e Drigo, R., Mora-Garzon, M., Ueta, C. B., Caicedo, A., Fekete, C., et al. (2013) · Journal of Clinical Investigation

Thyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth Factors

Cited by 155

The Arcuate Nucleus Is the Major Source for Neuropeptide Y-Innervation of Thyrotropin-Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus 1

Légrádi, G., & Lechan, R. M. (1998) · Endocrinology

Neuropeptides and Animal PhysiologyHypothalamic control of reproductive hormones

Cited by 138

Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: role of neuronal afferents and type 2 deiodinase

Fekete, C., & Lechan, R. M. (2007) · Frontiers in Neuroendocrinology

Thyroid Disorders and TreatmentsHypothalamic control of reproductive hormones

Cited by 137