The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Induction of Adiponectin in Skeletal Muscle by Inflammatory Cytokines: in Vivo and in Vitro Studies
Open accessAbstract
Adiponectin (ApN) is an adipocytokine that plays a fundamental role in energy homeostasis and counteracting inflammation. We examined whether ApN could be induced in a nonadipose tissue, the skeletal muscle, in vivo, and in cultured myotubes in response to lipopolysaccharides or proinflammatory cytokines. We next explored the underlying mechanisms. In vivo, injection of lipopolysaccharides to mice caused, after 24 h, an approximately 10-fold rise in ApN mRNA abundance and a concomitant 70% increase in ApN levels in tibialis anterior muscle. This ApN induction was reproduced in C2C12 myotubes cultured for 48 h with a proinflammatory cytokine combination, interferon-gamma + TNFalpha. This effect occurred in a time- and dose-dependent manner. Several pieces of evidence suggest that nitric oxide (NO) mediates this up-regulation by cytokines in myotubes or muscle. First, ApN was induced in vitro exclusively in the experimental conditions that stimulated NO production. Second, inducible NO synthase mRNA induction or NO production clearly preceded ApN mRNA induction. Third, preventing NO production by inhibitors of the NO synthases, nitro-L-arginine methyl ester or NG-methyl-L-arginine, suppressed the inductive effect of the cytokines in vitro and in vivo. Finally, ApN mRNA induction by cytokines was reproduced in cultured human myotubes. In conclusion, our data provide evidence that adiponectin is up-regulated in vivo and in vitro in human and rodent myotubes in response to inflammatory stimuli. The underlying mechanisms seem to involve a NO-dependent pathway. This overexpression may be viewed as a local antiinflammatory protection and a way to deliver extra energy supplies during inflammation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Besides being an adipokine, ApN can also be a true myokine [36,37].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [36]
In the citing paper
“ApN up-regulation was also reproduced in cultured murine or human myotubes in response to pro-inflammatory cytokines, reactive oxygen species (ROS) inducers or triglycerides [36,38].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [36]
In the citing paper
“Although it is mainly secreted by adipocytes under normal conditions, ApN may be produced in skeletal muscle of mice submitted to stressful challenges.”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [36]
In the citing paper
“Thus, acute (lipopolysaccharides (LPS) injection) or low-grade inflammation (genetic or nutritional induced obesity) enhanced ApN expression in muscle of challenged mice [36,38,39,40].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [36]
In the citing paper
“Moreover, myotubes from DMD patients were unable to produce ApN for local protection [57], unlike non-dystrophic myotubes challenged by inflammation [36].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [36]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003) · Nature · doi:10.1038/nature01705 · Cited by 3,176
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526
Novel Modulator for Endothelial Adhesion Molecules
Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., et al. (1999) · Circulation · doi:10.1161/01.cir.100.25.2473 · Cited by 2,158
Fruebis, J., Tsao, T., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2005 · Cited by 2,007
Ouchi, N., Kihara, S., Arita, Y., Okamoto, Y., Maeda, K., Kuriyama, H., Hotta, K., Nishida, M., Takahashi, M., Muraguchi, M., et al. (2000) · Circulation · doi:10.1161/01.cir.102.11.1296 · Cited by 1,730
Maeda, N., Takahashi, M., Funahashi, T., Kihara, S., Nishizawa, H., Kishida, K., Nagaretani, H., Matsuda, M., Komuro, R., Ouchi, N., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2094 · Cited by 1,673
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–241 of 241
The secretome of brown adipose tissue
Hansen, I. R. (2014) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 3
Adiponectin and central nervous system disorders: Regulatory mechanisms and therapeutic potential
Li, M., Wu, M., Gao, H., Xue, X., Xiao, W., & Zhu, L. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108260 · Cited by 2
The locoregional adiponectin and its synergistic antitumor effect with HIF‐1α blockade in TSCC
Guo, X., Wu, M., Zhao, G., Wu, F., Xu, Y., Yin, M., & Xiang, L. (2021) · Oral Diseases · doi:10.1111/odi.13948 · Cited by 2
Bùi, K. C., Nguyen, M. L. T., Barat, S., Scholta, T., Xing, J., Bhuria, V., Sipos, B., Wilkens, L., Nguyen, L. T., Le, H. S., et al. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673254969231122114107 · Cited by 2
Anatomy and Physiology of Adipose Tissue
Huang, Y., Hu, Y., Chen, H., Cai, Z., & He, B. (2024) · Contemporary Endocrinology · doi:10.1007/978-3-031-72570-8_2 · Cited by 2
Mleczko, E., Mirek, W., Dąbrowski, Z., Frączek, B., Forczek, W., Sudoł, G., & Gradek, J. (2019) · Journal of Kinesiology and Exercise Sciences · doi:10.5604/01.3001.0015.5535 · Cited by 2
Adiponectin and immune tolerance in type 1 diabetes
Pang, T. (2011) · University of Birmingham Institutional Research Archive (University of Birmingham) · Cited by 2
Tilg, H., & Hotamışlıgil, G. S. (2006) · Cited by 2
New-Onset Diabetes in Heart Failure Patients: A Complex Relationship with Clinical Implications
Roux, J. A. F., Chillarón, J. J., Benaiges, D., & Pedro‐Botet, J. (2014) · Journal of Cardiology and Therapy · Cited by 1
Adiponectin, Diabetes, and the Cardiovascular System
Gasbarrino, K., Boutari, C., Filippaios, A., Gianopoulos, I., Daskalopoulou, S. S., & Mantzoros, C. S. (2023) · Contemporary cardiology · doi:10.1007/978-3-031-13177-6_8 · Cited by 1
Obesity-mediated insulin resistance in target tissues: role of adiponectin, fetuin-A, and irisin
Mukherjee, S., Das, S., Chattopadhyay, D., & Mukhopadhyay, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-85732-1.00041-4 · Cited by 2
Adaptive Contribution of Thyroid Hormones in Obesity
Özçelik, F., DAŞTAN, A. İ., Pençe, H. H., & Çıracı, M. Z. (2019) · International Journal of Negative Results · doi:10.14302/issn.2641-9181.ijnr-18-2530 · Cited by 1
Adiponectin in Gastrointestinal Malignancies
Farran, B., Atiquah, I. Z., & Park, D. (2020) · Diagnostics and therapeutic advances in GI malignancies · doi:10.1007/978-981-15-5471-1_3 · Cited by 1
Adipocytokine Dysregulation, Obesity and the Metabolic Syndrome
Smith, U., & Yang, X. (2011) · Wiley eBooks · doi:10.1002/9781444347319.ch14 · Cited by 1
Molecular characterisation of the adiponectin receptors, AdipoR1 and AdipoR2
Keshvari, S. (2016) · The University of Queensland · doi:10.14264/uql.2016.782 · Cited by 1
Rola adiponektyny w rozrodzie samic
Drwal, E., & Rak, A. (2014) · Jagiellonian University Repository (Jagiellonian University)
Metabolische Wirkungen des ersten nicht-peptidischen Angiotensin II Rezeptor Typ 2 Agonisten
Wardat, S. (2012) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-8248
The effects of sleep dysregulation and adiponectin on immunity in older adults
Rossi, A. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)
Adiponectina e TNF-a no desenvolvimento de Mieloma Múltiplo
Serra, C. S. P. (2010) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/2znt-3m06
Molecular and physiological regulation of adiponectin exocytosis in white adipocytes
Komai, A. M. (2015) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Dadson, J. K. E. (2014) · YorkSpace (York University)
Effects of nutrients and exercise on skeletal muscle and adipose tissue
Rokling-Andersen, M. H. (2009) · NORA - Norwegian Open Research Archives
Ng, T. (2007) · UWA Profiles and Research Repository (UWA)
Srinivasan, V. (2015) · Shodhganga
Whitehead, J. P., & Richards, A. A. (2010) · Wiley eBooks · doi:10.1002/9783527629527.ch11
Eckel, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809518-8.00004-0
Wei, W., Zeng, H., & Mao, L. (2022) · Research Square · doi:10.21203/rs.3.rs-2028673/v1
Wei, W., Zeng, H., & Mao, L. (2022) · Research Square · doi:10.21203/rs.3.rs-2028673/v2
Bhaktha, G., Shivananda Nayak, B., & Shantaram, M. (2022) · International Journal of Noncommunicable Diseases · doi:10.4103/jncd.jncd_77_22
Ectopic adipogenesis in response to injury and material implantation in an autoimmune mouse modelPreprint
Ngo, T. B., Josyula, A., DeStefano, S., Fertil, D., Faust, M., Lokwani, R., & Sadtler, K. (2023) · bioRxiv · doi:10.1101/2023.10.05.561105
Chetty, K., Khathi, A., Schneider, S.-R., & Marx, G. (2023) · Series of Endocrinology Diabetes and Metabolism · doi:10.54178/jsedmv5i3001
Low serum adiponectin levels are associated with an increased risk of diabetes in obese dogs
Lu, J., Zhu, D. ‐., Wu, Z. Q., Liu, L., Hao, F., Jiang, Z. ‐., & Xu, W. ‐. (2024) · Journal of Small Animal Practice · doi:10.1111/jsap.13758
A Novel ELISA System for Measuring Modified LDL-Adiponectin Complex
Sasaoka, M., Kakino, A., Villalobos-Labra, R., Yamashita, Y., Spaans, F., Joshita, S., Hosoda, H., Uehara, T., Chen, C., Davidge, S. T., et al. (2025) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.65377
Kawamoto, R., Kikuchi, A., Ninomiya, D., Kumagi, T., & Abe, M. (2025) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.70037
Huang, R., Xu, S., Guo, Q., Cao, S., Tang, D., & Yi, X. (2026) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2026.112743
Rôle de la mPGES-1 dans le développement de l'inflammation chronique de bas seuil et de l'obésité
Clément, P. (2018) · theses.fr (ABES) · doi:10.70675/03fb1889z1609z4461z931dze2b1aebfa2b6
Delbarba, A., Amer, M., Vena, W., Cangiano, B., Ferrante, E., Pizzocaro, A., Chilà, A., Romeo, M., Lanzi, V., Buoso, C., et al. (2026) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-026-10054-5
Adipokine in Metabolic Liver Disease: Adipo–Brain–Liver Cross talk
苏喻乐, Yang, Y., Sun, W., Yu, Z., Wang, Y., 刘世新, Chen, Z., Li, Y., Yang, X., Liu, J., et al. (2026) · International Journal of Endocrinology · doi:10.1155/ije/9009628
Adipocytokines and sex hormone disorders in patients with chronic renal failure (CRF).
Niemczyk, S., Romejko, K., & Niemczyk, L. (2012) · PubMed · Cited by 9
Metadata
- Authors
- Delaigle, A. M., Jonas, J.-C., Bauche, I. B., Cornu, O., & Brichard, S. M.
- Affiliations
- UCLouvain (BE)
- Corresponding author
- Brichard, Sonia M.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2004-12
- Volume
- 145
- Issue
- 12
- Pages
- 5589-5597
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2050900577
- Cited by
- 241
- References
- 41
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 13 · 2023: 9 · 2022: 6 · 2021: 11 · 2020: 7 · 2019: 12 · 2018: 10 · 2017: 14 · 2016: 7 · 2015: 10 · 2014: 7 · 2013: 13 · 2012: 22
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- adiponectin, skeletal muscle, inflammatory cytokines, lipopolysaccharide, nitric oxide, inducible nitric oxide synthase, interferon-gamma, TNF-α, myotubes, anti-inflammatory signaling, energy homeostasis, tibialis anterior
- MeSH terms
- Animals, Antineoplastic Agents, Cells, Cultured, Humans, Interferon-gamma, Lipopolysaccharides, Male, Mice, Inbred Strains, RNA, Messenger, Tumor Necrosis Factor-alpha, Gene Expression, Muscle, Skeletal, Myoblasts, Intercellular Signaling Peptides and Proteins, Mice, Adiponectin, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
