The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Abstract
Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2-3-fold elevation in circulating Acrp30 levels, which triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress glucose production. We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.
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Adiponectin administration decreases IHTG, increases hepatic insulin sensitivity, and reverses obesity-related skeletal muscle insulin resistance.
“Adiponectin administration decreases IHTG (35), increases hepatic insulin sensitivity (36), and reverses obesity-related skeletal muscle insulin resistance (37).”
From Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity (2009) · cites this paper as [36]
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- Authors
- Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Scherer, Philipp E.
- Venue
- Nature Medicine
- Published
- 2001-08
- Volume
- 7
- Issue
- 8
- Pages
- 947-953
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1524321743
- Cited by
- 2,526
- References
- 33
- Citations by year
- 2026: 12 · 2025: 23 · 2024: 38 · 2023: 44 · 2022: 51 · 2021: 54 · 2020: 67 · 2019: 72 · 2018: 62 · 2017: 81 · 2016: 79 · 2015: 84 · 2014: 106 · 2013: 129 · 2012: 133
- FWCI
- 104.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM007491)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32 DK 07513-15, R01DK055758, T32DK007513)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- adiponectin, hepatic insulin action, insulin sensitivity, glucose production, hyperglycemia, ob/ob mice, streptozotocin-induced diabetes, adipose tissue, adipokines, glucose metabolism
- MeSH terms
- Animals, Blood Proteins, Energy Intake, Cell Line, Glucose, Humans, Hypoglycemic Agents, Insulin, Liver, Mice, Inbred C57BL, Proteins, Recombinant Proteins, Thiazoles, Adipocytes, Intercellular Signaling Peptides and Proteins, Thiazolidinediones, Mice, Adiponectin
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