Cited by 195Bone health and osteoporosis researchParathyroid Disorders and TreatmentsBone Metabolism and Diseases

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Calcitonin Plays a Critical Role in Regulating Skeletal Mineral Metabolism during Lactation

Woodrow, Janine P., Sharpe, Christopher J., Fudge, Neva J., Hoff, Ana O., Gagel, Robert F., Kovacs, Christopher S.·2006·Endocrinology

DOI 10.1210/en.2005-1616

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Abstract

The maternal skeleton rapidly demineralizes during lactation to provide calcium to milk, responding to the stimuli of estrogen deficiency and mammary-secreted PTH-related protein. We used calcitonin/calcitonin gene-related peptide-alpha (Ctcgrp) null mice to determine whether calcitonin also modulates lactational mineral metabolism. During 21 d of lactation, spine bone mineral content dropped 53.6% in Ctcgrp nulls vs. 23.6% in wild-type (WT) siblings (P < 0.0002). After weaning, bone mineral content returned fully to baseline in 18.1 d in Ctcgrp null vs. 13.1 d in WT (P < 0.01) mice. Daily treatment with salmon calcitonin from the onset of lactation normalized the losses in Ctcgrp null mice, whereas calcitonin gene-related peptide-alpha or vehicle was without effect. Compared with WT, Ctcgrp null mice had increased circulating levels of PTH and up-regulation of mammary gland PTH-related protein mRNA. In addition, lactation caused the Ctcgrp null skeleton to undergo more trabecular thinning and increased trabecular separation compared with WT. Our studies confirm that an important physiological role of calcitonin is to protect the maternal skeleton against excessive resorption and attendant fragility during lactation and reveal that the postweaning skeleton has the remarkable ability to rapidly recover even from losses of over 50% of skeletal mineral content.

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COPP, D. H., CAMERON, E. C., CHENEY, B. A., DAVIDSON, A. G. F., & HENZE, K. G. (1962) · Endocrinology · doi:10.1210/endo-70-5-638 · Cited by 697
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SHENNAN, D. B., & Peaker, M. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.925 · Cited by 413
Changes in Bone Density With Lactation
Sowers, M. R. (1993) · JAMA · doi:10.1001/jama.1993.03500240074029 · Cited by 373
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Show all 70 references

Research works printed but not linked: 4

[16]16. Deftos LJ 2003 Calcitonin. In: Favus MJ, ed. Primer on the metabolic bone diseases and disorders of mineral metabolism. 5th ed. Washington, DC: ASBMR Press; 137-141
[19]19. Barlet JP, Garel JM 1975 Physiological role of calcitonin in pregnant goats and ewes. In: Talmage RV, Owen M, Parsons A, eds. Calcium regulating hormones: Proc Fifth Parathyroid Conference, Oxford, UK, 1974. 1st ed. Amsterdam: Excerpta Medica; 119 -121
[39]39. Ju ¨ppner H, Kronenberg HM 2003 Parathyroid hormone. In: Favus MJ, ed. Primer on the metabolic bone diseases and disorders of mineral metabolism. 5th ed. Washington, DC: ASBMR Press; 117-124
[66]66. Kovacs CS, Kronenberg HM 2003 Skeletal physiology: pregnancy and lacta- tion. In: Favus MJ, ed. Primer on the metabolic bone diseases and disorders of mineral metabolism. 5th ed. Washington, DC: ASBMR Press; 80 -86 Endocrinology is published monthly by The Endocrine Society (http://www.endo-society.org), the foremost professional society serving the endocrine community.

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Effect of protease inhibitors on pulmonary bioavailability of therapeutic proteins and peptides in the rat
Amancha, K. P., & Hussain, A. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.11.008 · Cited by 17
Mineral Homeostasis in Murine Fetuses Is Sensitive to Maternal Calcitriol but Not to Absence of Fetal Calcitriol
Ryan, B. A., Alhani, K., Sellars, K. B., Kirby, B. J., St‐Arnaud, R., Kaufmann, M., Jones, G., & Kovács, C. S. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3642 · Cited by 17
1,25-Dihydroxyvitamin D3 contributes to regulating mammary calcium transport and modulates neonatal skeletal growth and turnover cooperatively with calcium
Ji, J., Lu, R., Zhou, X., Xue, Y., Shi, C., Goltzman, D., & Miao, D. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00173.2011 · Cited by 16
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Miller, S. C. (2006) · Endocrinology · doi:10.1210/en.2006-0599 · Cited by 16
Zoledronate prevents lactation induced bone loss and results in additional post-lactation bone mass in mice
Wendelboe, M. H., Thomsen, J. S., Henriksen, K., Vegger, J. B., & Brüel, A. (2016) · Bone · doi:10.1016/j.bone.2016.03.012 · Cited by 15
Calcitriol-Dependent and -Independent Regulation of Intestinal Calcium Absorption, Osteoblast Function, and Skeletal Mineralization during Lactation and Recovery in Mice
Ryan, B. A., McGregor, N. E., Kirby, B. J., Al-Tilissi, A., Poulton, I. J., Sims, N. A., & Kovács, C. S. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4712 · Cited by 15
Conversations between breast and bone: Physiological bone loss during lactation as evolutionary template for osteolysis in breast cancer and pathological bone loss after menopause
Wysolmerski, J. J. (2007) · BoneKEy-Osteovision · doi:10.1138/20070268 · Cited by 15
Osteoporosis Associated with Pregnancy
Wagman, R. B., & Marcus, R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00044-3 · Cited by 15
Transient expression of the calcitonin receptor by enteric neurons of the embryonic and early post-natal mouse
Wookey, P. J., Turner, K. N., & Furness, J. B. (2012) · Cell and Tissue Research · doi:10.1007/s00441-011-1303-6 · Cited by 15
Serotonin stimulated parathyroid hormone related protein induction in the mammary epithelia by transglutaminase-dependent serotonylation
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Kovács, C. S., & Kronenberg, H. M. (2018) · Primer on the metabolic bone diseases and disorders of mineral metabolism · doi:10.1002/9781119266594.ch20 · Cited by 12
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Changes in bone turnover and calcium homeostasis during pregnancy and lactation in mammals: a meta-analysis.
Torres, D. A., Freitas, M., & Gonçalves, R. V. (2018) · Reproduction, Fertility and Development · doi:10.1071/rd17163 · Cited by 11
Strontium biokinetic model for the lactating woman and transfer to breast milk: application to Techa River studies
Shagina, N. B., Tolstykh, E. I., Fell, T. P., Smith, T. J., Harrison, J. D., & Дегтева, М. О. (2015) · Journal of Radiological Protection · doi:10.1088/0952-4746/35/3/677 · Cited by 11
Graduate Student Literature Review: Serotonin and calcium metabolism: A story unfolding
Connelly, M. K., Cheng, A. A., & Hernandez, L. L. (2021) · Journal of Dairy Science · doi:10.3168/jds.2021-20610 · Cited by 10
Low protein intake during reproduction compromises the recovery of lactation‐induced bone loss in female mouse dams without affecting skeletal muscles
Kanakis, I., Alameddine, M., Scalabrin, M., Hof, R. V., Liloglou, T., Ozanne, S. E., Goljanek‐Whysall, K., & Vasilaki, A. (2020) · The FASEB Journal · doi:10.1096/fj.202001131r · Cited by 10
Pr-AKI: Acute Kidney Injury in Pregnancy – Etiology, Diagnostic Workup, Management
Scurt, F. G., Morgenroth, R., Bose, K., Mertens, P. R., & Chatzikyrkou, C. (2022) · Geburtshilfe und Frauenheilkunde · doi:10.1055/a-1666-0483 · Cited by 11
The Serotonergic System and Bone Metabolism During Pregnancy and Lactation and the Implications of SSRI Use on the Maternal-Offspring Dyad
Fricke, H. P., & Hernandez, L. L. (2023) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-023-09535-z · Cited by 9
Physiology of Calcium, Phosphorus, and Bone Metabolism During Pregnancy, Lactation, and Postweaning
Kovács, C. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814823-5.00005-2 · Cited by 9
Origins of Osteoclasts
Galson, D. L., & Roodman, G. D. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375670-1.10002-0 · Cited by 9
Disorders of Mineral and Bone Metabolism During Pregnancy and Lactation
Kovács, C. S., Chakhtoura, M., & Fuleihan, G. E. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814823-5.00021-0 · Cited by 9
Loss of 24-hydroxylated catabolism increases calcitriol and fibroblast growth factor 23 and alters calcium and phosphate metabolism in fetal mice
Bennin, D., Hartery, S. A., Kirby, B. J., Maekawa, A. S., St‐Arnaud, R., & Kovács, C. S. (2024) · JBMR Plus · doi:10.1093/jbmrpl/ziae012 · Cited by 8
Murine Fetal Serum Phosphorus is Set Independent of FGF23 and PTH, Except in the Presence of Maternal Phosphate Loading
Sellars, K. B., Ryan, B. A., Hartery, S. A., Kirby, B. J., & Kovács, C. S. (2020) · Endocrinology · doi:10.1210/endocr/bqaa202 · Cited by 8
Parathyroid Hormone, Parathyroid Hormone-Related Protein, and Calcitonin
Holt, E. H., & Wysolmerski, J. J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-381978-9.10041-1 · Cited by 9
Negative autoregulation of RANKL and c-Src signaling in osteoclasts
Yogo, K., Ishida‐Kitagawa, N., & Takeya, T. (2007) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-007-0751-2 · Cited by 8
Bone metabolism: a note on the significance of mouse models
Raška, O., Bernášková, K., & Raška, I. (2009) · Physiological Research · doi:10.33549/physiolres.931459 · Cited by 8

Authors: Woodrow, J. P., Sharpe, C. J., Fudge, N. J., Hoff, A. O., Gagel, R. F., & Kovacs, C. S.
Affiliations: Memorial University of Newfoundland (CA)
The University of Texas MD Anderson Cancer Center (US)
ORCID: Fudge, Neva J.
Hoff, Ana O.
Gagel, Robert F.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2006-09
Volume: 147
Issue: 9
Pages: 4010-4021
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2005-1616
OpenAlex: W2038783196
Cited by: 195
References: 70
Citations by year: 2026: 5 · 2025: 4 · 2024: 13 · 2023: 6 · 2022: 5 · 2021: 12 · 2020: 14 · 2019: 11 · 2018: 7 · 2017: 16 · 2016: 9 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 16
FWCI: 10.18
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Society for Endocrinology
Memorial University of Newfoundland
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords: calcitonin, lactation, bone demineralization, salmon calcitonin, PTH-related protein, parathyroid hormone, estrogen deficiency, trabecular bone, bone mineral content
MeSH terms: Animals, Biomechanical Phenomena, Bone and Bones, Bone Diseases, Metabolic, Bone Resorption, Calcitonin, Calcium, Duodenum, Estradiol, Female, Intestinal Absorption, Lactation, Mammary Glands, Animal, Milk, Minerals, Parathyroid Hormone, Pregnancy, RNA, Messenger, Bone Density, Calcitonin Gene-Related Peptide, Mice, Knockout, Parathyroid Hormone-Related Protein, Mice

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Calcitonin Plays a Critical Role in Regulating Skeletal Mineral Metabolism during Lactation

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