The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
RET/PTC Rearrangements and BRAF Mutations in Thyroid Tumorigenesis
Abstract
Thyroid papillary carcinoma is the most common type of endocrine cancer. It is frequently associated with genetic alterations leading to activation of the MAPK signaling pathway. The two most frequently affected genes, BRAF and RET, are activated by either point mutation or as a result of chromosomal rearrangement. These mutations are tumorigenic in thyroid follicular cells and correlate with specific phonotypical features and biological properties of papillary carcinomas, including tumor aggressiveness and response to radioiodine therapy. Molecular inhibitors that block RET/PTC or BRAF kinase activity have shown substantial therapeutic effects in the experimental systems and are currently being tested in clinical trials.
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Citations
Cites
Mutations of the BRAF gene in human cancer
Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674
Cited by
The changing incidence of thyroid cancer
Kitahara, C. M., & Sosa, J. A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.110 · Cited by 1,051
Genetic Alterations in the Phosphatidylinositol-3 Kinase/Akt Pathway in Thyroid Cancer
Xing, M. (2010) · Thyroid · doi:10.1089/thy.2010.1646 · Cited by 305
Papillary Thyroid Carcinoma Variants
Lloyd, R. V., Buehler, D., & Khanafshar, E. (2011) · Head and Neck Pathology · doi:10.1007/s12105-010-0236-9 · Cited by 277
Romei, C., Ciampi, R., Faviana, P., Agate, L., Molinaro, E., Bottici, V., Basolo, F., Miccoli, P., Pacini, F., Pinchera, A., et al. (2008) · Endocrine Related Cancer · doi:10.1677/erc-07-0130 · Cited by 160
Self-citationGenetic mutations, molecular markers and future directions in research
Patel, K. N. (2013) · Oral Oncology · doi:10.1016/j.oraloncology.2013.03.437 · Cited by 6
Metadata
- Authors
- Ciampi, R., & Nikiforov, Y. E.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2007-03-01
- Volume
- 148
- Issue
- 3
- Pages
- 936-941
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2023325202
- Cited by
- 241
- References
- 1
- FWCI
- 10.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ciampi, R., & Nikiforov, Y. E. (2007). RET/PTC Rearrangements and BRAF Mutations in Thyroid Tumorigenesis. Endocrinology. https://doi.org/10.1210/en.2006-0921
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
