The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Social Isolation Affects the Development of Obesity and Type 2 Diabetes in Mice
Abstract
Social isolation is associated with increased risks of mortality and morbidity. In this study, we show that chronic individual housing accelerated body weight gain and adiposity in KK mice but not C57BL6J mice, and fully developed diabetes in KKAy mice. Individually housed KK and KKAy mice increased body weight gain over the initial 2 wk without increased daily average food consumption compared with group-housed animals. The individually housed KK and KKAy mice then gradually increased food consumption for the next 1 wk. The chronic social isolation-induced obesity (SIO) was associated with hyperleptinemia and lower plasma corticosterone and active ghrelin levels but not hyperinsulinemia. Elevated plasma leptin in the SIO suppressed expression of 5-HT2C receptor in white adipose tissue. The SIO was also associated with decreased expression of β3-adrenergic receptors in white adipose tissue and hypothalamic leptin receptor, which might be secondary to the enhanced adiposity. Interestingly, social isolation acutely reduced food consumption and body weight gain compared with group-housed obese db/db mice with leptin receptor deficiency. Social isolation-induced hyperglycemia in KKAy mice was associated with increased expression of hepatic gluconeogenetic genes independent of insulin. These findings suggest that social isolation promotes obesity due to primary decreased energy expenditure and secondary increased food consumption, which are independent of the disturbed leptin signaling, in KK mice, and develops into insulin-independent diabetes associated with increased expression of hepatic gluconeogenetic genes in KKAy mice. Thus, social isolation can be included in the environmental factors that contribute to the development of obesity and type 2 diabetes.
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“increases obesity and Type 2 diabetes in mice;14”
From Social isolation (2011) · cites this paper as [14]
In the citing paper
“experimental studies in nonhuman social species indicate that isolation has direct, deleterious physiological effects.”
From Social isolation (2011) · cites this paper as [14]
Citations
Cites
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Loneliness and Cardiovascular Disease
Agarwal, S. K. (2021) · International Journal of Medicine · doi:10.14419/ijm.v9i1.31462
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van Heijningen, S. (2022) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.218473111
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Boriati, D., & D’Ambrosio, M. (2022) · SICUREZZA E SCIENZE SOCIALI · doi:10.3280/siss2022-002010
Personality Traits And Eating Disorders
Călin, M. F., & Sălceanu, C. (2023) · European Proceedings of Educational Sciences · doi:10.15405/epes.23045.54
RetractedInvolvement of a serotonin/GLP-1 circuit in adolescent isolation-induced diabetesPreprint
Kolling, L. J., Khan, K. M., Balasubramanian, N., Guo, D., Rahmouni, K., & Marcinkiewcz, C. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.12.544498
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Male manipulation impinges on social-dependent tumor suppression in Drosophila melanogaster femalesPreprint
Montagne, J., Akiki, P., Delamotte, P., Poidevin, M., van Dijk, E., Petit, A. J. R., Rouzic, A. L., Mery, F., & Marion‐Poll, F. (2023) · Research Square · doi:10.21203/rs.3.rs-3575658/v1
Retraction notice to "Personality Traits and Eating Disorders"
Călin, M. F., & Sălceanu, C. (2023) · European Proceedings of Educational Sciences · doi:10.15405/epes.23125.149
RetractedThe impact of social partners: investigating mixed-strain housing effects on aging in micePreprint
Lee, C.-L., Lin, Y.-C., & Kuo, T.-H. (2024) · Research Square · doi:10.21203/rs.3.rs-4820360/v1
The impact of social partners: investigating mixed-strain housing effects on aging in female mice
Lee, C., Lin, Y.-C., & Kuo, T.-H. (2024) · Biogerontology (Dordrecht) · doi:10.1007/s10522-024-10139-1
Delamotte, P., Akiki, P., Poidevin, M., Naquin, D., de Tilques, M. D. T., Cheng, X., Mery, F., Marion‐Poll, F., & Montagne, J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.21.683679
Aging reveals divergent responses of AgRP/NPY neurons to diet in male and female micePreprint
Brothers, T., Wei, W., Korgan, A. C., Bridges, Z., & O’Connell, K. M. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.20.689576
Social isolation stress, obesity, and breast cancer risk in mice
Sumis, A. M. (2014) · DigitalGeorgetown (Georgetown University Library)
Metadata
- Authors
- Nonogaki, K., Nozue, K., & Oka, Y.
- Affiliations
- Tohoku University (JP)
- ORCID
- Nonogaki, Katsunori
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2007-10-01
- Volume
- 148
- Issue
- 10
- Pages
- 4658-4666
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2032850135
- Cited by
- 115
- References
- 34
- Citations by year
- 2025: 8 · 2024: 6 · 2023: 11 · 2022: 14 · 2021: 8 · 2020: 10 · 2019: 2 · 2018: 9 · 2017: 10 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 5 · 2012: 1
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (KH 21016)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- social isolation, obesity, type 2 diabetes, KK mice, leptin, hyperleptinemia, 5-HT2C receptor, beta3-adrenergic receptor, leptin receptor, dietary intake, energy expenditure, hepatic gluconeogenesis, corticosterone, ghrelin, white adipose tissue
- MeSH terms
- Uncoupling Protein 2, Uncoupling Protein 1, Adipose Tissue, Animals, Body Weight, Diabetes Mellitus, Type 2, Eating, Energy Metabolism, Homeostasis, Ion Channels, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Obesity, Organ Size, RNA, Messenger, Social Isolation, Gene Expression, Disease Progression, Muscle, Skeletal, Leptin, Mitochondrial Proteins, Receptor, Serotonin, 5-HT2C, Peroxisome Proliferator-Activated Receptors, Mice
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