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Cited by 186Endometriosis Research and TreatmentEstrogen and related hormone effectsInflammatory mediators and NSAID effects

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Inflammatory Status Influences Aromatase and Steroid Receptor Expression in Endometriosis

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Bukulmez, Orhan, Hardy, Daniel B., Carr, Bruce R., Word, R. Ann, Mendelson, Carole R.·2008·Endocrinology
DOI 10.1210/en.2007-0665PMC PMC2275353
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Abstract

Aberrant up-regulation of aromatase in eutopic endometrium and implants from women with endometriosis has been reported. Aromatase induction may be mediated by increased cyclooxygenase-2 (COX-2). Recently, we demonstrated that progesterone receptor (PR)-A and PR-B serve an antiinflammatory role in the uterus by antagonizing nuclear factor kappaB activation and COX-2 expression. PR-C, which antagonizes PR-B, is up-regulated by inflammation. Although estrogen receptor alpha (ERalpha) is implicated in endometriosis, an antiinflammatory role of ERbeta has been suggested. We examined stage-specific expression of aromatase, COX-2, ER, and PR isoform expression in eutopic endometrium, implants, peritoneum, and endometrioma samples from endometriosis patients. Endometrial and peritoneal biopsies were obtained from unaffected women and those with fibroids. Aromatase expression in eutopic endometrium from endometriosis patients was significantly increased compared with controls. Aromatase expression in endometriosis implants was markedly increased compared with eutopic endometrium. Aromatase mRNA levels were increased significantly in red implants relative to black implants and endometrioma cyst capsule. Moreover, COX-2 expression was increased in implants and in eutopic endometrium of women with endometriosis as compared with control endometrium. As observed for aromatase mRNA, the highest levels of COX-2 mRNA were found in red implants. The ratio of ERbeta/ERalpha mRNA was significan…

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Metadata

Authors
Bukulmez, O., Hardy, D. B., Carr, B. R., Word, R. A., & Mendelson, C. R.
Affiliations
  • Departments of Obstetrics and Gynecology (O.B., B.R.C., R.A.W., C.R.M.), The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390
  • The University of Texas Southwestern Medical Center (US)
Corresponding author
Mendelson, Carole R.
ORCID
Venue
Endocrinology
Publisher
The Endocrine Society
Published
2007-11-29
Volume
149
Issue
3
Pages
1190-1204
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
DOI
10.1210/en.2007-0665
PMC
PMC2275353
OpenAlex
W2052591056
Cited by
186
References
0
Citations by year
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FWCI
15.10
Type
journal article
Language
en
Open access
Locations
  • Endocrinology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK031206, DK31206)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords
endometriosis, aromatase, cyclooxygenase-2, progesterone receptor isoforms, estrogen receptor alpha, estrogen receptor beta, endometrioma, eutopic endometrium, inflammation, NF-κB, disease progression
MeSH terms
Adult, Aromatase, Cross-Sectional Studies, Endometriosis, Endometrium, Female, Humans, Inflammation, Ovary, Peritoneum, Prospective Studies, Receptors, Estrogen, Receptors, Progesterone, RNA, Messenger, Up-Regulation, Case-Control Studies, Protein Isoforms, Estrogen Receptor alpha, Estrogen Receptor beta, Cyclooxygenase 2

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