Evidence for estrogen synthesis in adenomyotic tissues
Abstract
Objective To investigate steroidogenesis in eutopic and ectopic endometrial tissues in adenomyosis.Study design Aromatase and estrone sulfatase activities were determined by anion-exchange resin column chromatography, thin-layer chromatography, and cocrystallization. The effects of danazol on the activity of these enzymes were also examined. Moreover, localization of aromatase in eutopic and ectopic endometrial tissues was immunohistochemically examined with antihuman placental aromatase cytochrome P-450 antibody.Results Aromatase and estrone sulfatase activities were detected in ectopic endometrium. The activity of these enzymes was significantly suppressed by danazol. In addition, aromatase was immunohistochemically detected in glandular cells of eutopic and ectopic endometrial tissues.Conclusions The results suggest that estrogen is synthesized in the eutopic and ectopic endometrial tissues of women with uterine adenomyosis and that it may affect the growth of adenomyosis. Danazol suppressed synthesis of estrogen in vitro.
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The results of activated estrogen signaling and reduced ERα expression in OE and AD lesions are consistent with overwhelming data showing the same.
“Our results of activated estrogen signaling as well as reduced ERα expression in OE and AD lesions are consistent with overwhelming data showing the same (Yamamoto et al., 1993; Brandenberger et al., 1999; Fujimoto et al., 1999; Attar et al., 2009; Mehasseb et al., 2011; Heublein et al., 2012; Samartzis et al., 2012).”
From Progressively diminished estrogen signaling concordant with increased fibrosis in ectopic endometrium (2025) · cites this paper as Yamamoto et al., 1993
Genes involved in estrogen biosynthesis, such as StAR and P450 aromatase, are upregulated in adenomyosis.
“In addition, genes involved in estrogen biosynthesis, such as steroidogenic acute regulatory protein (StAR) and P450 aromatase, are upregulated in adenomyosis [48,49].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [49]
Increased local production of estrogen is common to all subtypes of endometriosis and even to adenomyosis.
“Moreoever, increased local production of estrogen is common to all subtypes of endometriosis83 and even to adenomyosis84.”
From Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells (2020) · cites this paper as [84]
Expression of P450 aromatase is increased in adenomyotic tissue and in ectopic and eutopic endometrium of women with endometriosis.
“The expression of the P450 aromatase is increased in adenomyotic tissue and in the ectopic and eutopic endometrium of women with endometriosis [35–41].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [35]
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- Authors
- Yamamoto, T., Noguchi, T., Tamura, T., Kitawaki, J., & Okada, H.
- Affiliations
- Kyoto Prefectural University of Medicine (JP)
- Corresponding author
- Yamamoto, Takara
- ORCID
- Kitawaki, Jo
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1993-09
- Volume
- 169
- Issue
- 3
- Pages
- 734-738
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2028723332
- Cited by
- 111
- References
- 16
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 5
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Keywords
- adenomyosis, estrogen synthesis, steroidogenesis, aromatase, estrone sulfatase, ectopic endometrium, eutopic endometrium, danazol, endometrial glandular cells
- MeSH terms
- Adult, Aromatase, Chromatography, Ion Exchange, Danazol, Dose-Response Relationship, Drug, Endometriosis, Estrogens, Female, Humans, Middle Aged, Myometrium, Neoplasms, Hormone-Dependent, Sulfatases, Uterine Neoplasms, Gene Expression Regulation, Enzymologic, Aromatase Inhibitors
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