Cited by 181Thyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsThyroid Cancer Diagnosis and Treatment

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Life without Thyroxine to 3,5,3′-Triiodothyronine Conversion: Studies in Mice Devoid of the 5′-Deiodinases

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Galton, Valerie Anne, Schneider, Mark J., Clark, Ann S., St. Germain, Donald L.·2009·Endocrinology

DOI 10.1210/en.2008-1572PMC PMC2689801

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Abstract

Considerable indirect evidence suggests that the type 2 deiodinase (D2) generates T(3) from T(4) for local use in specific tissues including pituitary, brown fat, and brain, whereas the type I deiodinase (D1) generates T(3) from T(4) in the thyroid and peripheral tissues primarily for export to plasma. From studies in deiodinase-deficient mice, the importance of the D2 for local T(3) generation has been confirmed. However, the phenotypes of these D1 knockout (KO) and D2KO mice are surprisingly mild and their serum T(3) level, general health, and reproductive capacity are unimpaired. To explore further the importance of 5'deiodination in thyroid hormone economy, we used a mouse devoid of both D1 and D2 activity. In general, the phenotype of the D1/D2KO mouse is the sum of the phenotypes of the D1KO and D2KO mice. It appears healthy and breeds well, and most surprisingly its serum T(3) level is normal. However, impairments in brain gene expression and possibly neurological function are somewhat greater than those seen in the D2KO mouse, and the serum rT(3) level is elevated 6-fold in the D1/D2KO mouse but only 2-fold in the D1KO mouse and not at all in the D2KO mouse. The data suggest that whereas D1 and D2 are not essential for the maintenance of the serum T(3) level, they do serve important roles in thyroid hormone homeostasis, the D2 being critical for local T(3) production and the D1 playing an important role in iodide conservation by serving as a scavenger enzyme in peripheral tissues and the thyroid.

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Macchia, E., Lombardi, M., Raffaelli, V., Piaggi, P., Macchia, L., Scattina, I., & Martino, E. (2014) · Clinical Endocrinology · doi:10.1111/cen.12556 · Cited by 23
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Síbio, M. T. D. (2014) · World Journal of Clinical Oncology · doi:10.5306/wjco.v5.i3.503 · Cited by 22
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Scott, E. A. (1976) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.1976.168.11.1047 · Cited by 21
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Role of thyroid hormones in different aspects of nervous system regeneration in vertebrates
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Kiss, D., Ioja, E., Toth, I., Barany, Z., Jocsak, G., Bartha, T., Horvath, T., & Zsarnovszky, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051440 · Cited by 18
Gene polymorphisms and thyroid hormone signaling: implication for the treatment of hypothyroidism
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Cognitive Function and Quality of Life in Mild Thyroid Hormone Deficiency
Tognini, S., Pasqualetti, G., Calsolaro, V., Polini, A., & Monzani, F. (2014) · Recent Patents on Endocrine Metabolic & Immune Drug Discovery · doi:10.2174/1872214808666140723111533 · Cited by 16
An Essential Physiological Role for MCT8 in Bone in Male Mice
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Minato, K., Nagao, H., Imazu, T., & Takahashi, K. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00214 · Cited by 4
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López‐Juárez, A., Delgado, G., Aceves, C., & Anguiano, B. (2009) · The Prostate · doi:10.1002/pros.21015 · Cited by 3
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Vergauwen, L., Stinckens, E., Villeneuve, D. L., & Knapen, D. (2022) · OECD series on adverse outcome pathways · doi:10.1787/dc406014-en · Cited by 4
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Rampy, J., Torres-Manzo, A. P., Hoffsmith, K., Loberg, M. A., Sheng, Q., Salas-Lucia, F., Bianco, A. C., Drigo, R. A. E., Wang, H., Weiss, V. L., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci194207 · Cited by 2
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Carrasco, J. R. B. (2010) · Dialnet (Universidad de la Rioja) · Cited by 2
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Solís, J. C., Orozco, A., García, C., Robles‐Osorio, L., & Valverde, C. (2011) · PubMed · Cited by 2
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Ayad, E., El-orbany, N., Hydar, A., & Elbakry, K. (2020) · African Journal of Biological Sciences · doi:10.21608/ajbs.2020.89612 · Cited by 2
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Dentice, M., & Salvatore, D. (2019) · Springer eBooks · doi:10.1007/978-3-319-72102-6_5 · Cited by 1
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Kasaikina, M. V. (2011) · Lincoln (University of Nebraska) · Cited by 1
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van der Deure, W. M., Medici, M., Peeters, R. P., & Visser, T. J. (2010) · Endocrine updates · doi:10.1007/978-1-4419-1485-9_2 · Cited by 1
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Macchia, P. E., & Fenzi, G. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00094-9
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Simonides, W. S. (2020) · Springer eBooks · doi:10.1007/978-3-030-36871-5_7
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Authors: Galton, V. A., Schneider, M. J., Clark, A. S., & St. Germain, D. L.
Affiliations: Departments of Physiology (V.A.G., M.J.S., D.L.S.G.), Dartmouth Medical School, Lebanon, New Hampshire 03756
Dartmouth College (US)
ORCID: Galton, Valerie Anne
Clark, Ann S.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2009-02-05
Volume: 150
Issue: 6
Pages: 2957-2963
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2008-1572
PMC: PMC2689801
OpenAlex: W2109458276
Cited by: 181
References: 37
Citations by year: 2026: 1 · 2025: 10 · 2024: 4 · 2023: 8 · 2022: 9 · 2021: 6 · 2020: 10 · 2019: 11 · 2018: 8 · 2017: 13 · 2016: 12 · 2015: 9 · 2014: 19 · 2013: 6 · 2012: 11
FWCI: 13.11
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Endocrinology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Dartmouth College
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK054716, DK-54716)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD09020, R01HD009020)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords: type 2 deiodinase, type I deiodinase, triiodothyronine, thyroxine, thyroid hormone homeostasis, reverse T3, brain gene expression
MeSH terms: Iodothyronine Deiodinase Type II, Animals, Brain, Homeostasis, Iodide Peroxidase, Iodine, Learning, Locomotion, Memory, Mice, Inbred C57BL, RNA, Messenger, Thyroid Gland, Thyrotropin, Thyroxine, Triiodothyronine, Mice, Knockout, Mice

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Life without Thyroxine to 3,5,3′-Triiodothyronine Conversion: Studies in Mice Devoid of the 5′-Deiodinases

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