Cited by 185Fibroblast Growth Factor ResearchAdipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance

Hale, Clarence, Chen, Michelle M., Stanislaus, Shanaka, Chinookoswong, Narumol, Hager, Todd, Wang, Minghan, Véniant, Murielle M., Xu, Jing·2012·Endocrinology

DOI 10.1210/en.2010-1262

Open this paper in CoChat — free account

Abstract

Circulating levels of fibroblast growth factor 21 (FGF21), a metabolic regulator of glucose, lipid, and energy homeostasis, are elevated in obese diabetic subjects, raising questions about potential FGF21 resistance. Here we report tissue expression changes in FGF21 and its receptor components, and we describe the target-organ and whole-body responses to FGF21 in ob/ob and diet-induced obese (DIO) mice. Plasma FGF21 concentrations were elevated 8- and 16-fold in DIO and ob/ob mice, respectively, paralleling a dramatic increase in hepatic FGF21 mRNA expression. Concurrently, expression levels of βKlotho, FGF receptor (FGFR)-1c, and FGFR2c were markedly down-regulated in the white adipose tissues (WAT) of ob/ob and DIO mice. However, dose-response curves of recombinant human FGF21 (rhFGF21) stimulation of ERK phosphorylation in the liver and WAT were not right shifted in disease models, although the magnitude of induction in ERK phosphorylation was partially attenuated in DIO mice. Whole-body metabolic responses were preserved in ob/ob and DIO mice, with disease models being more sensitive and responsive than lean mice to the glucose-lowering and weight-loss effects of rhFGF21. Endogenous FGF21 levels, although elevated in diseased mice, were below the half-maximal effective concentrations of rhFGF21, suggesting a state of relative deficiency. Hepatic and WAT FGF21 mRNA expression levels declined after rhFGF21 treatment in the absence of the increased expression levels of βKlotho and FGFR. We conclude that overt FGF21 resistance was not evident in the disease models, and increased hepatic FGF21 expression as a result of local metabolic changes is likely a major cause of elevated circulating FGF21 levels.

Integrity signals

Registry

Crossref · 10.1210/en.2010-1262

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Analyzing real-time PCR data by the comparative CT method
Schmittgen, T. D., & Livak, K. J. (2008) · Nature Protocols · doi:10.1038/nprot.2008.73 · Cited by 26,190
FGF-21 as a novel metabolic regulator
Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125
Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21
Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504
Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States
Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151
Self-citation
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice.
Halaas, J. L., Boozer, C., Blair-West, J., Fidahusein, N., Denton, D. A., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8878 · Cited by 1,033
Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
Zhang, X., Yeung, D. C. Y., Karpisek, M., Stejskal, D., Zhou, Z.-G., Liu, F., Wong, R. L. C., Chow, W.-S., Tso, A. W. K., Lam, K. S. L., et al. (2008) · Diabetes · doi:10.2337/db07-1476 · Cited by 908
Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State
Fisher, F. M., Chui, P. C., Antonellis, P. J., Bina, H. A., Kharitonenkov, A., Flier, J. S., & Maratos-Flier, E. (2010) · Diabetes · doi:10.2337/db10-0193 · Cited by 830
Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21
Kurosu, H., Choi, M., Ogawa, Y., Dickson, A. S., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Rosenblatt, K. P., Kliewer, S. A., & Kuro-o, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704165200 · Cited by 748
The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
Kharitonenkov, A., Wroblewski, V. J., Koester, A., Chen, Y.-F., Clutinger, C. K., Tigno, X. T., Hansen, B. C., Shanafelt, A. B., & Etgen, G. J. (2007) · Endocrinology · doi:10.1210/en.2006-1168 · Cited by 738

Show all 30 references

Sorted by citations

Items 101–185 of 185

Pharmacological Therapy of Non-Alcoholic Fatty Liver Disease: What Drugs Are Available Now and Future Perspectives
Pennisi, G., Celsa, C., Spatola, F., Dallio, M., Federico, A., & Petta, S. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16224334 · Cited by 25
FGF21 Induces Skeletal Muscle Atrophy and Increases Amino Acids in Female Mice: A Potential Role for Glucocorticoids
Larson, K. R., Jayakrishnan, D., Sauza, K. A. S., Goodson, M. L., CHAFFIN, A. T. B., Davidyan, A., Pathak, S. J., Fang, Y., Magaña, D. G., Miller, B. F., et al. (2024) · Endocrinology · doi:10.1210/endocr/bqae004 · Cited by 24
Advances in Biological Functions and Clinical Studies of FGF21
Lin, W. J., Zhang, T., Zhou, Y., Zheng, J., & Lin, Z. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s317096 · Cited by 24
A pyrexic effect of FGF21 independent of energy expenditure and UCP1
Zouhar, P., Janovská, P., Stanić, S., Bardová, K., Funda, J., Haberlova, B., Andersen, B., Rossmeisl, M., Cannon, B., Kopecký, J., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101324 · Cited by 24
Dietary induction of obesity and insulin resistance is associated with changes in Fgf21 DNA methylation in liver of mice
Geißler, C., Krause, C., Neumann, A., Britsemmer, J. H., Taege, N., Grohs, M., Kaehler, M., Cascorbi, I., Lewis, A. G., Seeley, R. J., et al. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108907 · Cited by 22
Fibroblast Growth Factor 21 (FGF21) Administration Sex-Specifically Affects Blood Insulin Levels and Liver Steatosis in Obese Ay Mice
En, M., Kazantseva, A. Y., Dubinina, A., Denisova, E. I., Jakovleva, T., Balybina, N., Bgatova, N. P., Baranov, K. O., & Бажан, Н. М. (2021) · Cells · doi:10.3390/cells10123440 · Cited by 20
Relationship between FGF21 and drug or nondrug therapy of type 2 diabetes mellitus
Guo, C. Y., Zhao, L., Li, Y., Deng, X., & Yuan, G. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29879 · Cited by 21
Basal and postprandial change in serum fibroblast growth factor-21 concentration in type 1 diabetic mellitus and in healthy controls
Zibar, K., Blaslov, K., Bulum, T., Čuča, J. K., & Duvnjak, L. S. (2014) · Endocrine · doi:10.1007/s12020-014-0413-9 · Cited by 19
Epicardial fat, body mass index, and triglyceride are independent contributors of serum fibroblast growth factor 21 level in obese premenopausal women
Akyıldız, Z. İ., Polat, S., Yürekli, B. Ş., Kocabaş, G. Ü., Tülüce, K., Tülüce, S. Y., Kocabaş, U., Bozkaya, G., Yüksel, A., & Nazlı, C. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-014-0185-3 · Cited by 19
Fibroblast growth factor 21, fibroblast growth factor receptor 1, and β-Klotho expression in bovine growth hormone transgenic and growth hormone receptor knockout mice
Brooks, N. E., Hjortebjerg, R., Henry, B. E., List, E. O., Kopchick, J. J., & Berryman, D. E. (2016) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2016.08.003 · Cited by 18
Dual effects of fibroblast growth factor 21 on hepatic energy metabolism
Samms, R. J., Murphy, M., Fowler, M. J., Cooper, S., Emmerson, P. J., Coşkun, T., Adams, A. C., Kharitonenkov, A., Ebling, F. J. P., & Tsintzas, K. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0334 · Cited by 17
Oral administration of a new HRI activator as a new strategy to improve high‐fat‐diet‐induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21
Zarei, M., Pujol, E., Quesada‐López, T., Villarroya, F., Barroso, E., Vázquez, S., Pizarro‐Delgado, J., Palomer, X., & Vázquez‐Carrera, M. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14678 · Cited by 17
Effects of High Fat Feeding on Liver Gene Expression in Diabetic Goto-Kakizaki Rats
Almon, R. R., DuBois, D. C., Sukumaran, S., Wang, X., Bai, X., Nie, J., & Jusko, W. J. (2012) · Gene Regulation and Systems Biology · doi:10.4137/grsb.s10371 · Cited by 16
CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms
Satoh, A., Han, S., Araki, M., Nakagawa, Y., Ohno, H., Mizunoe, Y., Kumagai, K., Murayama, Y., Osaki, Y., IWASAKI, H. O., et al. (2020) · iScience · doi:10.1016/j.isci.2020.100930 · Cited by 15
FGF21 Depletion Attenuates Colitis through Intestinal Epithelial IL-22-STAT3 Activation in Mice
Liu, L., Li, F., Shao, T., Zhang, L., Lee, J., Dryden, G. W., McClain, C. J., Zhao, C., & Feng, W. (2023) · Nutrients · doi:10.3390/nu15092086 · Cited by 14
The effects of exercise on FGF21 in adults: a systematic review and meta-analysis
Liu, C., Yan, X., Zong, Y., He, Y., Yang, G., Xiao, Y., & Wang, S. (2024) · PeerJ · doi:10.7717/peerj.17615 · Cited by 14
Attenuation of FGF21 signalling might aggravate the impairment of glucose homeostasis during the high sucrose diet induced transition from prediabetes to diabetes in WNIN/GR-Ob rats
Kondeti, S., Dinesh Yadav, D. M., Muralidhar, M. N., Prasad, S. M. V. K., Nemani, H., & Kalashikam, R. R. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111252 · Cited by 12
Hepatic PTEN Signaling Regulates Systemic Metabolic Homeostasis through Hepatokines-Mediated Liver-to-Peripheral Organs Crosstalk
Berthou, F., Sobolewski, C., Abegg, D., Fournier, M., Maeder, C., Dolicka, D., de Sousa, M. C., Adibekian, A., & Foti, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073959 · Cited by 14
Hypocaloric Diet Prevents the Decrease in FGF21 Elicited by High Phosphorus Intake
Pineda, C., Ríos, R., Raya, A. I., Rodríguez, M., Aguilera‐Tejero, E., & Lopez, I. (2018) · Nutrients · doi:10.3390/nu10101496 · Cited by 13
Letter to the Editor: Parameters, Characteristics, and Criteria for Defining the Term “FGF21 Resistance”
Tanajak, P. (2017) · Endocrinology · doi:10.1210/en.2017-00056 · Cited by 13
Identification of Sp1 as a Transcription Activator to Regulate Fibroblast Growth Factor 21 Gene Expression
Chen, S., Li, H., Zhang, J., Jiang, S., Zhang, M., Xu, Y., Dong, K., Yang, Y., Fang, Q., & Jia, W. (2017) · BioMed Research International · doi:10.1155/2017/8402035 · Cited by 12
Beyond obesity – thermogenic adipocytes and cardiometabolic health
Aldiss, P., Dellschaft, N. S., Sacks, H. S., Budge, H., & Symonds, M. E. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0007 · Cited by 10
Balanced Coagonist of GLP-1 and Glucagon Receptors Corrects Dyslipidemia by Improving FGF21 Sensitivity in Hamster Model
PATEL, V. G., Joharapurkar, A. A., Kshirsagar, S. G., Patel, H., Pandey, D., Patel, D. N., Sutariya, B., Patel, M. S., Bahekar, R. H., & Jain, M. R. (2017) · Drug Research · doi:10.1055/s-0043-118808 · Cited by 11
FGF21 contributes to metabolic improvements elicited by combination therapy with exenatide and pioglitazone in patients with type 2 diabetes
Samms, R. J., Cheng, C., Fourcaudot, M. J., Heikkinen, S., Khattab, A., Adams, J. M., Cersósimo, E., Triplitt, C. L., PUCKETT, C. L., Tsintzas, K., et al. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00050.2022 · Cited by 10
Physical Exercise-Induced FGF-21 to Fight Obesity: An Update Review
Vecchiatto, B., de Castro, T. L., Muller, C. R., Azevedo‐Martins, A. K., & Evangelista, F. S. (2022) · Obesities · doi:10.3390/obesities2040031 · Cited by 9
Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability
An, S. J., Mohanty, J., Tomé, F., Suzuki, Y., Lax, I., & Schlessinger, J. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2219128120 · Cited by 9
Potential of Hibiscus sabdariffa Linn. in managing FGF21 resistance in diet‐induced‐obesity rats via miR‐34a regulation
Kartinah, N. T., Komara, N. K., Noviati, N. D., Dewi, S., Yolanda, S., Radhina, A., Heriyanto, H., & Sianipar, I. R. (2021) · Veterinary Medicine and Science · doi:10.1002/vms3.653 · Cited by 9
ADAM10-mediated β-klotho degradation: a key to FGF21 resistance in senescent vascular endothelial cells
Huang, Y., Zhang, Y., Yang, N., Qian, Z., Fang, Z., Zeng, L., Huang, Y., Li, H., Luo, M., Yan, J., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01463-y · Cited by 8
Synbiotics intake improves disturbed metabolism in a rat model of high fat diet-induced obesity; A potential role of adipose tissue browning
Mahmoud, H., Sallam, R. M., Henin, C. M. A., Moustafa, A. S., Mohamed, R. H., & Mohamad, M. I. (2022) · Obesity Medicine · doi:10.1016/j.obmed.2022.100414 · Cited by 8
Studying sex differences in responses to fibroblast growth factor 21 administration in obese mice consuming a sweet-fat diet
Бажан, Н. М., Jakovleva, T., Kazantseva, A. Y., Костина, Н. Е., Orlov, P. E., Balybina, N., Baranov, K. O., & En, M. (2023) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vjgb-23-40 · Cited by 9
Resistance to the Beneficial Metabolic Effects and Hepatic Antioxidant Defense Actions of Fibroblast Growth Factor 21 Treatment in Growth Hormone-Overexpressing Transgenic Mice
Boparai, R. K., Arum, O., Miquet, J. G., Masternak, M. M., Bartke, A., & Khardori, R. K. (2015) · International Journal of Endocrinology · doi:10.1155/2015/282375 · Cited by 8
Regulation of fibroblast growth factor 9 on the differentiation of goat intramuscular adipocytes
Huang, K., Wang, Y., Zhu, J., Xiong, Y., & Lin, Y. (2021) · Animal Science Journal · doi:10.1111/asj.13627 · Cited by 8
A Chronic GM(2) Gangliosidosis Variant with a HEXA Splicing Defect: Quantitation of HEXA mRNAs in Normal and Mutant Fibroblasts
Fernandes, M. J., Hechtman, P., Boulay, B., & Kaplan, F. (1997) · European Journal of Human Genetics · doi:10.1159/000484748 · Cited by 8
Commentary: FGF21 Holds Promises for Treating Obesity-related Insulin Resistance and Hepatosteatosis
Alisi, A., Panera, N., & Nobili, V. (2013) · Endocrinology · doi:10.1210/en.2013-1828 · Cited by 8
α1-Adrenergic receptor downregulates hepatic FGF21 production and circulating FGF21 levels in mice
Nonogaki, K., & Kaji, T. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.12.008 · Cited by 7
Rapamycin‐ameliorated diabetic symptoms involved in increasing adiponectin expression in diabetic mice on a high‐fat diet
Gong, F., Ye, Y., Li, J., Zhao, H., & Li, X. (2017) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/j.kjms.2017.05.008 · Cited by 7
Sex-specific association between fibroblast growth factor 21 and type 2 diabetes: a nested case-control study in Singapore Chinese men and women
Wang, Y., Koh, W., Yuan, J., & Pan, A. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0216-0 · Cited by 7
The association between circulating irisin, osteocalcin and FGF21 levels with anthropometric characteristics and blood lipid profile in young obese male subjects
Sayharman, S. E., Belviranlı, M., & Okudan, N. (2025) · Advances in Medical Sciences · doi:10.1016/j.advms.2025.01.010 · Cited by 6
Obesity-resistance of UCP1-deficient mice associates with sustained FGF21 sensitivity in inguinal adipose tissue
Hazebroek, M. K., & Keipert, S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.909621 · Cited by 6
Association of Elevated Plasma FGF21 and Activated FGF21 Signaling in Visceral White Adipose Tissue and Improved Insulin Sensitivity in Gestational Diabetes Mellitus Subtype: A Case-Control Study
Wang, N., Sun, B., Guo, H., Jing, Y., Qi, R., Wang, M., Mi, Y., Chen, H., Song, L., & Cui, W. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.795520 · Cited by 6
Self-citation
Investigation of the Characteristics of Crimean Congo Hemorrhagic Fever Cases Reported in Afyonkarahisar Province
Korkmaz, D., Konya, P. Ş., & Demirtürk, N. (2022) · Turkish Journal of Parasitology · doi:10.4274/tpd.galenos.2022.14633 · Cited by 5
International Symposium on Ruminant Physiology: Endocrine adaptations to demanding physiological states in ruminants
Boisclair, Y. R., & Giesy, S. L. (2024) · Journal of Dairy Science · doi:10.3168/jds.2024-25799 · Cited by 5
Age of Cafeteria Diet Onset Influences Obesity Phenotype in Mice in a Sex-Specific Manner
Bazhan, N., Kazantseva, A., Dubinina, A., Balybina, N. Y., Jakovleva, T., & Makarova, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212436 · Cited by 4
Effect of Aerobic Exercise Training on Circulating Fibroblast Growth Factor-21 Response to Glucose Challenge in Overweight and Obese Men: A Pilot Study
Matsui, M., Kosaki, K., Myoenzono, K., Yoshikawa, T., Park, J., Kuro‐o, M., & Maeda, S. (2022) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-1902-3872 · Cited by 5
Treatment with FGFR2-IIIc monoclonal antibody suppresses weight gain and adiposity in KKAy mice
Nonogaki, K., Kaji, T., Yamazaki, T., & Murakami, M. (2016) · Nutrition and Diabetes · doi:10.1038/nutd.2016.41 · Cited by 5
Additive effect of leptin and palm-LEAP2(1–14) ameliorates obesity-induced metabolic stress in ob/ob mice
Peteláková, M., Bouacha, C., Neprašová, B., Sopko, Z., Áčová, A., Mráziková, L., Kozák, J., Zavřel, M., Cantel, S., Fehrentz, J., et al. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178542 · Cited by 4
Deletion of GFRAL blunts weight lowering effects of FGF21 in female mice
Buch-Rasmussen, A. S., Andersen, H., Stage, C., Hansen, A. M. K., Paulsen, S. J., Gillum, M. P., Andersen, B., Secher, A., Latta, M. R., Clemmensen, C., et al. (2025) · Journal of Endocrinology · doi:10.1530/joe-25-0017 · Cited by 4
Plasma Levels of Fibroblast Growth Factor 21 and Adverse Kidney Outcomes
Koh, H. B., Kim, H. J., Kim, H. W., Chang, T. I., Park, J. T., Yoo, T., Kang, S., & Han, S. H. (2025) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2024.10.026 · Cited by 4
Metformin Preserves Insulin Secretion in Pancreatic β-cells through FGF21/Akt Pathway In vitro and In vivo
Li, J., Jiang, Q., Wang, X., Hou, L., Wang, L., Lou, K., & Pang, S. (2023) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/0113862073246747230920170201 · Cited by 4
Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?
Balcázar‐Hernández, L., Basurto, L., Apolinar, L. M., Vega-García, S., Basurto-Acevedo, N. E., Murillo, C. M., & Sánchez‐Arenas, R. (2021) · Metabolites · doi:10.3390/metabo11110771 · Cited by 4
Effects of metformin on fibroblast growth factor 21 in patients with type 2 diabetes mellitus: faraway but so close
Al-Kuraishy, H. M., Al-Gareeb, A. I., Jabir, M. S., & Albukhaty, S. (2023) · The Egyptian Journal of Internal Medicine · doi:10.1186/s43162-023-00238-9 · Cited by 5
Efficacy of fibroblast growth factor 21 in non‐alcoholic fatty liver disease in guinea pigs
Klæbel, J. H., Lykkesfeldt, J., & Tveden‐Nyborg, P. (2022) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13705 · Cited by 4
FGF21 Is Released During Increased Lipogenesis State Following Rapid-Onset Radioiodine-Induced Hypothyroidism
Szczepańska, E., Glinicki, P., Zgliczyński, W., Slowinska-Srzednicka, J., Jastrzębska, H., & Gietka‐Czernel, M. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.900034 · Cited by 3
FGF21 upregulation by hepatitis C virus via the eIF2α-ATF4 pathway: implications for interferon signaling suppression and TRIM31-mediated TSC degradation
Liu, L., Ito, M., Sakai, S., Liu, J., Ohta, K., Saito, K., Nakashima, K., Satoh, S., Konno, A., & Suzuki, T. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1456108 · Cited by 3
A Tryptophan Hydroxylase Inhibitor Increases Hepatic FGF21 Production and Decreases Hepatic Gluconeogenesis Independently of Insulin in db/db Mice
Nonogaki, K., Kaji, T., & Murakami, M. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000480 · Cited by 3
FGF21 Levels in Pheochromocytoma/Functional Paraganglioma
Klímová, J., Zelinka, T., Rosa, J., Štrauch, B., Haluzíková, D., Haluzı́k, M., Holaj, R., Krátká, Z., Kvasnička, J., Ďurovcová, V., et al. (2019) · Cancers · doi:10.3390/cancers11040485 · Cited by 3
Analysis of serum levels and DNA methylation of fibroblast growth factor 21 using peripheral blood-derived genomes in patients with obesity
Shinozaki, H., Kawai, S., Gamo-Kawasaki, M., Takei, A., Tsujikado, K., Fukuda, K., Yamauchi, M., Hara, K., Tsuchiya, T., Takebayashi, K., et al. (2024) · Endocrine Journal · doi:10.1507/endocrj.ej23-0570 · Cited by 2
The effects of SGLT2 inhibitors on metabolic phenotype and FGF-21 expression from the adipose tissue and the liver are less pronounced in ob/ob mice
Vincenzo, A. D., Granzotto, M., Crescenzi, M., Fioretto, P., Vettor, R., & Rossato, M. (2025) · BMC Endocrine Disorders · doi:10.1186/s12902-025-01879-3 · Cited by 2
Anti-adiposity impact of phosphodiesterase-5 inhibitor, Sildenafil is possibly through browning of white adipose tissue and FGF21 in obese rats
Muhammad, M., Elwai, S., & Rahman, S. A. E. (2019) · Bulletin of Egyptian Society for Physiological Sciences · doi:10.21608/besps.2019.6747.1012 · Cited by 2
Endocrinology and metabolism
Li, X. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15793-6.00003-2 · Cited by 2
Fibroblast Growth Factor 21: Possible Role in Growth and Metabolic Development during Early Life, Nutritional Interactions and Biological Actions
Wali, J. A., Ramos-Nieves, J. M., Binia, A., & van der Beek, E. M. (2026) · Advances in Nutrition · doi:10.1016/j.advnut.2026.100713 · Cited by 1
Fibroblast growth factor-21 induces skeletal muscle atrophy and increases plasma amino acids in female mice: a potential role for glucocorticoidsPreprint
Larson, K. R., Jayakrishnan, D., Sauza, K. A. S., Goodson, M. L., CHAFFIN, A. T. B., Davidyan, A., Pathak, S. J., Fang, Y., Magaña, D. G., Miller, B. F., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.27.546599 · Cited by 1
Molecular Regulators of Metabolism and Cardiometabolic Disease
Sukmawati, I. R., & Wijaya, A. (2012) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v4i3.173
Regulation of Metabolism by Hepatic OXPHOS: A Dissertation
Akie, T. E. (2015) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/m2388v
Harnessing the Action of Fibroblast Growth Factor21 as a Therapeutic Agent
Brunetti, L., & Kagan, L. (2017) · Current Pharmacology Reports · doi:10.1007/s40495-017-0080-7
Towards Examining FGF21 Secretion from Pancreatic Islets in a Microfluidic Device
Green, B. J. (2012) · TSpace (University of Toronto)
Molecular Regulation of Gluconeogenesis by the Nuclear Receptors GR and LXRβ
Patel, R. (2015) · TSpace (University of Toronto)
Fibroblast Growth Factor 21 is a Novel Protein Sensor in Pregnancy
Sutton, E. F. (2017) · doi:10.31390/gradschool_dissertations.4263
FGF21 mediates corticosteroid-related bone mass loss through PPAR-$\gamma$
Guan, Y., Huang, J., Huang, S., Kasukurthi, M. V., Huang, Y., Li, D., Tan, S., Wang, S., Xin, N., Lin, J., et al. (2019) · IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · doi:10.1109/bibm47256.2019.8983042
Molecular description of fibroblast growth factor and mechanisms by which fibroblast growth factor-21 mediating biological actions and acting as a biologic biomarker of cardiovascular diseases
Melaku, L. S., & Debela, N. (2020) · Indian Journal of Health Sciences and Biomedical Research (KLEU) · doi:10.4103/kleuhsj.kleuhsj_92_20
Uninephrectomy and class II PI3K-C2β inactivation synergistically protect against obesity, insulin resistance and liver steatosis in mice
Alliouachene, S., Kieswich, J. E., Bilanges, B., McCafferty, K., Thiemermann, C., Vanhaesebroeck, B., & Yaqoob, M. (2020) · American Journal of Transplantation · doi:10.1111/ajt.16470
Mistranslation drives alterations in protein levels and the effects of a synonymous variant at the FGF21 locus
Bayoumi, A. (2020) · The Sydney eScholarship Repository (The University of Sydney)
Current World Literature
(2012) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e3283566807
The developing link of metabolic growth factors in insulin resistance
Gao, R., Hassan, W., Shahzadi, A., din, F. U., & Rasheed, H. M. F. (2017) · Journal of Contemporary Pharmacy · doi:10.56770/jcp201705
FGF-21 and GDF-15 Levels in Patients with Insulin Resistance and It's Relation with Other Biochemical Parameters
Çetiner, S. (2023) · Eurasian Journal of Medical Investigation · doi:10.14744/ejmi.2023.59132
Effect of Estradiol on Carbohydrate-Fat Metabolism and FGF21 System Activity in Female C57BL/6 Mice with Short-Term Consumption of the Cafeteria Diet
Jakovleva, T., Kazantseva, A., Mamontova, K. Y., & Bazhan, N. (2024) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093024020315
Effect of Estradiol on Carbohydrate-Fat Metabolism and FGF21 System Activity in Female C57BL/6 Mice with Short-Term Consumption of the Cafeteria Diet
Jakovleva, T., Kazantseva, A. Y., Mamontova, K. Y., & Бажан, Н. М. (2024) · Российский физиологический журнал им И М Сеченова · doi:10.31857/s0869813924040054
Effects of Asprosin and FGF21 on Weight Loss and Glucose Metabolism Following Sleeve Gastrectomy
Türker, A. S., Gündüz, U. R., Aykal, G., Dincer, A., Özkan, H., Çelik, Ö., & Aydın, M. A. (2025) · Indian Journal of Surgery · doi:10.1007/s12262-025-04356-2
Myokine-Mediated Muscle-Kidney Crosstalk
Formenti, P., & Umbrello, M. (2025) · Springer eBooks · doi:10.1007/978-3-032-01024-7_14
Étude du rôle de la production hépatique de glucose dans le développement du diabète et de l’obésité
Abdul-Wahed, A. (2012) · theses.fr (ABES) · doi:10.70675/61924053za287z4f04zb650zc51c1916ee64
La microalgue Odontella aurita prévient l'insulino-résistance et l'inflammation hépatiques induites par un régime hyper-lipidique : mise en évidence des mécanismes insulino-sensibilisateurs des acides gras polyinsaturés omega-3 au niveau neuronal.
Amine, H. (2016) · theses.fr (ABES) · doi:10.70675/8fc153dfzc95cz4209zabf7z1567442c940d
FGF21 targets pathways which enhance insulin sensitivity in brown adipose but not skeletal muscle in mice
Juber, M. C., King-McAlpin, S., Buscaglia, P., Sebag, J. A., & Potthoff, M. J. (2026) · Endocrinology · doi:10.1210/endocr/bqag040
Rôle des aminoacides ramifiés dans le déterminisme génétique de la résistance à l’insuline
Haydar, S. (2018) · theses.fr (ABES) · doi:10.70675/5c14c2c4z469bz40fazb55cz985ea78d6c2a
Klotho within cardio-renal-hepatic-metabolic health: Integrating mineral metabolism, organ crosstalk, and therapeutic opportunities
Taigade, S., Parab, S. B., & Doshi, G. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103390
Biological functions and emerging interplay of FGF21 and GDF15 in metabolic diseases and aging
Salmón‐Gómez, L., Keipert, S., Catalán, V., Rodrı́guez, A., Becerril, S., Frühbeck, G., & Gómez‐Ambrosi, J. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00627-w

Authors: Hale, C., Chen, M. M., Stanislaus, S., Chinookoswong, N., Hager, T., Wang, M., Véniant, M. M., & Xu, J.
Affiliations: Departments of Metabolic Disorders (C.H., M.M.C., S.S., N.C., M.W., M.M.V., J.X.), Thousand Oaks, California 91320
Amgen (United States) (US)
Corresponding author: Xu, Jing
ORCID: Hale, Clarence
Chen, Michelle M.
Véniant, Murielle M.
Xu, Jing
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2012-01-01
Volume: 153
Issue: 1
Pages: 69-80
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2010-1262
OpenAlex: W2158061384
Cited by: 185
References: 30
Citations by year: 2026: 5 · 2025: 7 · 2024: 10 · 2023: 11 · 2022: 16 · 2021: 14 · 2020: 10 · 2019: 14 · 2018: 11 · 2017: 20 · 2016: 14 · 2015: 12 · 2014: 12 · 2013: 8 · 2012: 20
FWCI: 5.19
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: FGF21, FGF21 resistance, obesity, insulin resistance, ob/ob mice, diet-induced obesity, β-Klotho, FGFR1c, white adipose tissue, ERK1/2 phosphorylation, glucose-lowering effect, weight loss, metabolic regulation
MeSH terms: Klotho Proteins, Animals, Disease Models, Animal, Fibroblast Growth Factors, Humans, Insulin Resistance, Liver, Male, Membrane Proteins, Mice, Inbred C57BL, Mice, Obese, Obesity, Recombinant Proteins, RNA, Messenger, Gene Expression, MAP Kinase Signaling System, Mice, Receptor, Fibroblast Growth Factor, Type 1, Receptor, Fibroblast Growth Factor, Type 2, Adipose Tissue, White, Diet, High-Fat

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks