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FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases

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Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework

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Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients

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Biomarkers of insulin sensitivity and insulin resistance: Past, present and future

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Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues

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Fibroblast Growth Factor-21 Is Induced in Human Skeletal Muscles by Hyperinsulinemia

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Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease

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Novel locus including FGF21 is associated with dietary macronutrient intake

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TNF-α Represses β-Klotho Expression and Impairs FGF21 Action in Adipose Cells: Involvement of JNK1 in the FGF21 Pathway

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Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3

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Serum Fibroblast Growth Factor-21 Levels Are Associated With Carotid Atherosclerosis Independent of Established Cardiovascular Risk Factors

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Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes

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Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance

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The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction

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Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice

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Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts Endoplasmic Reticulum Stress-induced Hepatic Steatosis

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Obesity and Thyroid Axis

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Fibroblast Growth Factor 21 Induces Glucose Transporter-1 Expression through Activation of the Serum Response Factor/Ets-Like Protein-1 in Adipocytes

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Circulating Fibroblast Growth Factor-23 Is Associated With Fat Mass and Dyslipidemia in Two Independent Cohorts of Elderly Individuals

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High Plasma Level of Fibroblast Growth Factor 21 Is an Independent Predictor of Type 2 Diabetes

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What lipodystrophies teach us about the metabolic syndrome

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Serum Levels of FGF-21 Are Increased in Coronary Heart Disease Patients and Are Independently Associated with Adverse Lipid Profile

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Exercise increases serum fibroblast growth factor 21 (FGF21) levels

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Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat

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Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB

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Circadian Rhythm of Circulating Fibroblast Growth Factor 21 Is Related to Diurnal Changes in Fatty Acids in Humans

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Metabolic interplay between white, beige, brown adipocytes and the liver

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FGF19 and FGF21 serum concentrations in human obesity and type 2 diabetes behave differently after diet- or surgically-induced weight loss

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Going Back to the Biology of FGF21: New Insights

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Fibroblast growth factor 21 and its novel association with oxidative stress

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Fibroblast Growth Factor 21 (FGF-21) and Its Relation to Obesity, Metabolic Syndrome, and Nonalcoholic Fatty Liver in Children: A Longitudinal Analysis

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Free Fatty Acids Link Metabolism and Regulation of the Insulin-Sensitizing Fibroblast Growth Factor-21

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Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21

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Determinants of GH resistance in malnutrition

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Butyrate to combat obesity and obesity‐associated metabolic disorders: Current status and future implications for therapeutic use

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Circulating Fibroblast Growth Factor 21 Is Induced by Peroxisome Proliferator-Activated Receptor Agonists But Not Ketosis in Man

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Fibroblast growth factor 21 and browning of white adipose tissue

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Fibroblast growth factor-21, energy balance and obesity

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Effects of a three‐month combined exercise programme on fibroblast growth factor 21 and fetuin‐A levels and arterial stiffness in obese women

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FGF21 reloaded: challenges of a rapidly growing field

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New developments in the biology of fibroblast growth factors

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Different roles of N‐ and C‐ termini in the functional activity of FGF21

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FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases

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Hepatic lipid metabolism and non-alcoholic fatty liver disease in aging

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Fibroblast Growth Factor 21 Improves Insulin Resistance and Ameliorates Renal Injury in db/db Mice

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Amino Acid Sensing in Metabolic Homeostasis and Health.

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Growth Hormone Induces Hepatic Production of Fibroblast Growth Factor 21 through a Mechanism Dependent on Lipolysis in Adipocytes

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Understanding bile acid signaling in diabetes: From pathophysiology to therapeutic targets

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FGF21 levels are increased in obesity and are independently associated with the Metabolic Syndrome in Humans. Diabetes 2008

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Running Title: FGF21 and the metabolic syndrome **Corresponding Authors:

Zhang, X., Yeung, D. C. Y., Msc, M. K., Phd, D. S., Department Of Pharmacology, Ka, L., & Medicine, S. F. (2007)

Fibroblast Growth Factor 21 as an emerging metabolic regulator: clinical perspectives

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Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity

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FGF21 Conducts a Metabolic Orchestra and Fat Is a Key Player

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