The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Maternal High-Fat Diet Effects on Third-Generation Female Body Size via the Paternal Lineage
Open accessAbstract
The health consequences of in utero exposure to maternal obesity on future generations are concerning because they contribute to increased rates of diabetes, cardiovascular disease, and metabolic syndrome. We previously reported that maternal high-fat diet exposure in mice resulted in an increase in body size and reduced insulin sensitivity that persisted across two generations via both maternal and paternal lineages. However, because the first generation's primordial germ cells may be affected by gestational exposure, analysis of phenotype transmission into a third generation (F3) is necessary to determine whether stable epigenetic programming has occurred. Therefore, we have examined the body size and insulin sensitivity of male and female F3 offspring. We found that only females displayed the increased body size phenotype, and this effect was only passed on via the paternal lineage. The finding of a paternally transmitted phenotype to F3 female offspring supports a stable germline-based transgenerational mode of inheritance; thus we hypothesized that imprinted genes may be involved in this epigenetic programming. Using a quantitative TaqMan Array for imprinted genes to examine paternally or maternally expressed loci in F3 female livers, we detected a potential dynamic pattern of paternally expressed genes from the paternal lineage that was not noted in the maternal lineage. These findings suggest that the environmental influence on developmental regulation of growth and body size may be the result of broad programming events at imprinted loci, thereby providing sex specificity to both the transmission and inheritance of traits related to disease predisposition.
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Citations
Cites
Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility
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Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
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“Similarly counterintuitive fluctuations in phenotypes across generations have been reported previously (41).”
BackgroundMaternal epigenetics and methyl supplements affect agouti gene expression in A vy /a mice
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Cited by
Rodgers, A. B., Morgan, C. P., Bronson, S. L., Revello, S., & Bale, T. L. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0914-13.2013 · Cited by 814
Self-citationFullston, T., Teague, E. M. C. O., Palmer, N. O., DeBlasio, M. J., Mitchell, M., Corbett, M., Print, C. G., Owens, J. A., & Lane, M. (2013) · The FASEB Journal · doi:10.1096/fj.12-224048 · Cited by 600
Babenko, O., Kovalchuk, I., & Metz, G. A. S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.013 · Cited by 513
Epigenetic and transgenerational reprogramming of brain development
Bale, T. L. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3818 · Cited by 505
Self-citationCommon cellular and molecular mechanisms in obesity and drug addiction
Kenny, P. J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3105 · Cited by 382
Metadata
- Authors
- Dunn, G. A., & Bale, T. L.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2011-06
- Volume
- 152
- Issue
- 6
- Pages
- 2228-2236
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2123870375
- Cited by
- 371
- References
- 51
- FWCI
- 32.23
- Type
- journal article
- Language
- en
- Open access
- green
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