Cited by 113Epigenetics and DNA MethylationBirth, Development, and HealthEffects and risks of endocrine disrupting chemicals

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Minireview: Transgenerational Epigenetic Inheritance: Focus on Endocrine Disrupting Compounds

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Rissman, Emilie F., Adli, Mazhar·2014·Endocrinology

DOI 10.1210/en.2014-1123PMC PMC4098001

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Abstract

The idea that what we eat, feel, and experience influences our physical and mental state and can be transmitted to our offspring and even to subsequent generations has been in the popular realm for a long time. In addition to classic gene mutations, we now recognize that some mechanisms for inheritance do not require changes in DNA. The field of epigenetics has provided a new appreciation for the variety of ways biological traits can be transmitted to subsequent generations. Thus, transgenerational epigenetic inheritance has emerged as a new area of research. We have four goals for this minireview. First, we describe the topic and some of the nomenclature used in the literature. Second, we explain the major epigenetic mechanisms implicated in transgenerational inheritance. Next, we examine some of the best examples of transgenerational epigenetic inheritance, with an emphasis on those produced by exposing the parental generation to endocrine-disrupting compounds (EDCs). Finally, we discuss how whole-genome profiling approaches can be used to identify aberrant epigenomic features and gain insight into the mechanism of EDC-mediated transgenerational epigenetic inheritance. Our goal is to educate readers about the range of possible epigenetic mechanisms that exist and encourage researchers to think broadly and apply multiple genomic and epigenomic technologies to their work.

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Authors: Rissman, E. F., & Adli, M.
Affiliations: University of Virginia (US)
Corresponding author: Adli, Mazhar
ORCID: Rissman, Emilie F.
Adli, Mazhar
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2014-08-01
Volume: 155
Issue: 8
Pages: 2770-2780
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2014-1123
PMC: PMC4098001
OpenAlex: W2139340966
Cited by: 113
References: 126
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 16 · 2019: 13 · 2018: 9 · 2017: 11 · 2016: 13 · 2015: 14
FWCI: 1.19
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Endocrinology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Environmental Health Sciences (R01ES022759)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Keywords: transgenerational epigenetic inheritance, endocrine disruptors, epigenetic mechanisms, parental exposure, epigenetic profiling, epigenetic memory
MeSH terms: Animals, Humans, Genomics, Inheritance Patterns, Epigenesis, Genetic, Endocrine Disruptors

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