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Minireview: Transgenerational Epigenetic Inheritance: Focus on Endocrine Disrupting Compounds
Open accessAbstract
The idea that what we eat, feel, and experience influences our physical and mental state and can be transmitted to our offspring and even to subsequent generations has been in the popular realm for a long time. In addition to classic gene mutations, we now recognize that some mechanisms for inheritance do not require changes in DNA. The field of epigenetics has provided a new appreciation for the variety of ways biological traits can be transmitted to subsequent generations. Thus, transgenerational epigenetic inheritance has emerged as a new area of research. We have four goals for this minireview. First, we describe the topic and some of the nomenclature used in the literature. Second, we explain the major epigenetic mechanisms implicated in transgenerational inheritance. Next, we examine some of the best examples of transgenerational epigenetic inheritance, with an emphasis on those produced by exposing the parental generation to endocrine-disrupting compounds (EDCs). Finally, we discuss how whole-genome profiling approaches can be used to identify aberrant epigenomic features and gain insight into the mechanism of EDC-mediated transgenerational epigenetic inheritance. Our goal is to educate readers about the range of possible epigenetic mechanisms that exist and encourage researchers to think broadly and apply multiple genomic and epigenomic technologies to their work.
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“Altered AVP and OT neuron numbers and innervation of sexually dimorphic regions associated with social and aggressive behaviors in multiple species; anxiogenic in multiple species”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [63]
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Cites
An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836
Long non-coding RNAs: insights into functions
Mercer, T. R., Dinger, M. E., & Mattick, J. S. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2521 · Cited by 5,654
Derrien, T., Johnson, R., Bussotti, G., Andrea Tanzer, A., Djebali, S., Tilgner, H., Guernec, G., Martin, D., Merkel, A., Knowles, D. G., et al. (2012) · Genome Research · doi:10.1101/gr.132159.111 · Cited by 5,135
Human DNA methylomes at base resolution show widespread epigenomic differences
Lister, R., Pelizzola, M., Dowen, R. H., Hawkins, R. D., Hon, G., Tonti-Filippini, J., Nery, J. R., Lee, L., Ye, Z., Ngo, Q.-M., et al. (2009) · Nature · doi:10.1038/nature08514 · Cited by 4,673
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
Kriaucionis, S., & Heintz, N. (2009) · Science · doi:10.1126/science.1169786 · Cited by 2,700
Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility
Anway, M. D., Cupp, A. S., Uzumcu, M., & Skinner, M. K. (2005) · Science · doi:10.1126/science.1108190 · Cited by 2,563
Herbst, A. L., Ulfelder, H., & Poskanzer, D. C. (1971) · New England Journal of Medicine · doi:10.1056/nejm197104222841604 · Cited by 2,545
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Research works printed but not linked: 2
- Department of Health and Human Services Centers for Disease Control and Prevention, 2013, Fourth National Report on Human Exposure to Environmental Chemicals
- National Institute of Environmental Health Sciences, 2009, Fourth National Report on Human Exposure to Environmental Chemicals
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Balthazart, J., & Ball, G. F. (2021) · doi:10.1002/9781119109556.ch6
Autism and Exposure to Environmental Chemicals
Bagasra, O., Heggen, C., & Hossain, M. I. (2018) · doi:10.1002/9781119042280.ch7
Epigenomic Measurements in Brain Tissues
Satterlee, J. S. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3474-4_148
Pino, M. T., & Cabilla, J. P. (2022) · Biomarkers in disease · doi:10.1007/978-3-030-87225-0_1-1
The Morphoprocess and the Diversity of Evolutionary Mechanisms of Metastable Structures
Granovitch, A. I. (2022) · Evolutionary Biology/Evolutionary biology · doi:10.1007/978-3-031-04783-1_9
Pino, M. T., & Cabilla, J. P. (2023) · Biomarkers in disease · doi:10.1007/978-3-031-07392-2_1
Female Antiestrogen and Antiandrogens
Barakat, R., Park, C., Oh, J., Bunnell, M., & Ko, C. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21477-6.00091-2
Epigenetics for Combating Drought Stress in Plants: Updated Methods and Current Achievements
Dhiman, V. K., Sudarshna, Kumar, R., Kumar, G., Dhiman, V. K., & Singh, D. (2025) · CABI climate change series. · doi:10.1079/9781800626102.0009
Lencu, C. C. G., Gerdanovics, C.-A., Orasan, O. H., Iancu, I., Gerdanovics, A., Perné, M.-G., Milaciu, M. V., Negrean, V., Dobrotă, I. R., & Alexescu, T. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167311
Ren, J., Peng, Y., Sun, C., Zhang, Y., Guan, Z., Li, J., Xia, S., Gao, Y., Wang, Y., Gao, C., et al. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.6c07960
Metadata
- Authors
- Rissman, E. F., & Adli, M.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Adli, Mazhar
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2014-08-01
- Volume
- 155
- Issue
- 8
- Pages
- 2770-2780
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- PMC
- PMC4098001
- OpenAlex
- W2139340966
- Cited by
- 113
- References
- 126
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 16 · 2019: 13 · 2018: 9 · 2017: 11 · 2016: 13 · 2015: 14
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Environmental Health Sciences (R01ES022759)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- transgenerational epigenetic inheritance, endocrine disruptors, epigenetic mechanisms, parental exposure, epigenetic profiling, epigenetic memory
- MeSH terms
- Animals, Humans, Genomics, Inheritance Patterns, Epigenesis, Genetic, Endocrine Disruptors
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