The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Effect of Sex Differences on Brain Mitochondrial Function and Its Suppression by Ovariectomy and in Aged Mice
Abstract
Sex steroids regulate brain function in both normal and pathological states. Mitochondria are an essential target of steroids, as demonstrated by the experimental administration of 17β-estradiol or progesterone (PROG) to ovariectomized female rodents, but the influence of endogenous sex steroids remains understudied. To address this issue, mitochondrial oxidative stress, the oxidative phosphorylation system, and brain steroid levels were analyzed under 3 different experimental sets of endocrine conditions. The first set was designed to study steroid-mediated sex differences in young male and female mice, intact and after gonadectomy. The second set concerned young female mice at 3 time points of the estrous cycle in order to analyze the influence of transient variations in steroid levels. The third set involved the evaluation of the effects of a permanent decrease in gonadal steroids in aged male and female mice. Our results show that young adult females have lower oxidative stress and a higher reduced nicotinamide adenine dinucleotide (NADH)-linked respiration rate, which is related to a higher pyruvate dehydrogenase complex activity as compared with young adult males. This sex difference did not depend on phases of the estrous cycle, was suppressed by ovariectomy but not by orchidectomy, and no longer existed in aged mice. Concomitant analysis of brain steroids showed that pregnenolone and PROG brain levels were higher in females during the reproductive period than in males and decreased with aging in females. These findings suggest that the major male/female differences in brain pregnenolone and PROG levels may contribute to the sex differences observed in brain mitochondrial function.
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In the citing paper
“Under physiological conditions, sex-specific differences in mitochondrial respiration, bioenergetics, and reactive oxygen species production have been reported in both human and animal studies.”
From Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know (2019) · cites this paper as [119]
In the citing paper
“mitochondria extracted from brain, liver, and cerebral arteries of female rodents displayed more efficient oxidative phosphorylation than in males”
From Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know (2019) · cites this paper as [119]
In the citing paper
“Estrogen and progesterone contributed to sex differences in cellular respiration and anti-oxidative functions of brain mitochondria in uninjured female rodents.”
From Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know (2019) · cites this paper as [119]
Citations
Cites
How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207
Biochemical and molecular investigations in respiratory chain deficiencies
Rustin, P., Chrétien, D., Bourgeron, T., Gérard, B., Rötig, A., Saudubray, J., & Münnich, A. (1994) · Clinica Chimica Acta · doi:10.1016/0009-8981(94)90055-8 · Cited by 1,265
Mouse Estrous Cycle Identification Tool and Images
Byers, S. L., Wiles, M. V., Dunn, S. L., & Taft, R. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035538 · Cited by 1,220
Neurosteroids: endogenous regulators of the GABAA receptor
Belelli, D., & Lambert, J. J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1703 · Cited by 1,159
Mitochondria and neuronal activity
Kann, O., & Kovács, R. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00222.2006 · Cited by 871
Mitochondrial Dysfunction in Neurodegenerative Diseases
Johri, A., & Beal, M. F. (2012) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.192138 · Cited by 806
Bains, J. S., & Shaw, C. A. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00045-3 · Cited by 718
Steroid hormone synthesis in mitochondria
Miller, W. L. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.04.014 · Cited by 510
Andersson, S., & Russell, D. W. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3640 · Cited by 501
Requirement for Superoxide in Excitotoxic Cell Death
Patel, M., Day, B. J., Crapo, J. D., Fridovich, I., & McNamara, J. O. (1996) · Neuron · doi:10.1016/s0896-6273(00)80052-5 · Cited by 436
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Gupte, R. P., Brooks, W. M., Vukas, R. R., Pierce, J. D., & Harris, J. L. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6171 · Cited by 533
Age and Sex Are Critical Factors in Ischemic Stroke Pathology
Roy-O’Reilly, M. A., & McCullough, L. D. (2018) · Endocrinology · doi:10.1210/en.2018-00465 · Cited by 498
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Rubin, J. B., Lagas, J. S., Broestl, L., Sponagel, J., Rockwell, N., Rhee, G., Rosen, S. F., Chen, S., Klein, R. S., Imoukhuede, P. I., et al. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00291-x · Cited by 391
Metadata
- Authors
- Gaignard, P., Savouroux, S., Liere, P., Pianos, A., Thérond, P., Schumacher, M., Slama, A., & Guennoun, R.
- Affiliations
- Université Paris-Sud (FR)
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2015-08
- Volume
- 156
- Issue
- 8
- Pages
- 2893-2904
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2175348882
- Cited by
- 150
- References
- 45
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 20 · 2023: 23 · 2022: 13 · 2021: 10 · 2020: 9 · 2019: 22 · 2018: 10 · 2017: 14 · 2016: 5 · 2015: 1
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- sex differences, brain mitochondria, mitochondrial oxidative stress, oxidative phosphorylation, pyruvate dehydrogenase complex, ovariectomy, gonadectomy, estrous cycle, pregnenolone, progesterone, aging, sex steroids
- MeSH terms
- Aging, Animals, Brain, Estradiol, Flavin-Adenine Dinucleotide, Female, Male, Mice, Inbred C57BL, Mitochondria, NAD, Ovariectomy, Sex Characteristics, Oxidative Stress, Cell Respiration, Mice
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