Cited by 183Hypothalamic control of reproductive hormonesNeuroendocrine regulation and behaviorRegulation of Appetite and Obesity

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The Arcuate Nucleus and the Control of Gonadotropin and Prolactin Secretion in the Female Rhesus Monkey (Macaca mulatta)*

PLANT, T. M., KREY, L. C., MOOSSY, J., McCORMACK, J. T., HESS, D. L., KNOBIL, E.·1978·Endocrinology

DOI 10.1210/endo-102-1-52

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Abstract

Attempts were made to destroy selectively the arcuate nucleus with radiofrequency current in adult female rhesus monkeys as a first step in identifying the areas of the mediobasal hypothalamus (MBH) that are responsible for the neural control of gonadotropin secretion in this species. Extensive or complete destruction of the arcuate region was produced in three animals and in two of these the lesion was confined primarily to the arcuate region and the dorsal aspect of the posterior median eminence. These lesions resulted in the cessation of LH and FSH secretion and blocked the positive feedback action of estradiol on gonadotropin release but did not appear to influence grossly basal thyroid and adrenocortical function, or to abolish GH discharge in response to insulin hypoglycemia. Adenohypophysial infarcts were not observed and exogenous LHRH and TRH induced marked discharges of the appropriate anterior pituitary hormones. In two additional animals with large hypothalamic lesions, destruction of the arcuate region was incomplete. In this group only partial inhibition of gonadotropin secretion was observed. LH and FSH secretion did not appear to be influenced in one animal bearing a large MBH lesion that entirely spared the arcuate region. Although serum prolactin remained at pre-lesion control levels after placement of the two relatively discrete lesions confined to the arcuate region, unambiguous increases in the secretion of this hormone were observed when the area of destruction encompassed tissue anterior and/or dorsal to the arcuate region. These observations suggest that the arcuate region is the primary structure mediating the hypothalamic control of gonadotropin secretion in the rhesus monkey. They also suggest that, in this species, the regions of the MBH involved with the regulation of gonadotropin release and those which control prolactin secretion are anatomically distinct.

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Authors: PLANT, T. M., KREY, L. C., MOOSSY, J., McCORMACK, J. T., HESS, D. L., & KNOBIL, E.
Affiliations: University of Pittsburgh (US)
ORCID: PLANT, T. M.
KREY, L. C.
HESS, D. L.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1978-01
Volume: 102
Issue: 1
Pages: 52-62
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo-102-1-52
OpenAlex: W2114815180
Cited by: 183
References: 0
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 9 · 2015: 6 · 2014: 6 · 2013: 8 · 2012: 5
FWCI: 7.53
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: arcuate nucleus, gonadotropin secretion, prolactin secretion, mediobasal hypothalamus, luteinizing hormone, follicle-stimulating hormone, estradiol positive feedback, hypothalamic-pituitary-gonadal axis, radiofrequency lesions, rhesus monkeys, anterior pituitary, growth hormone
MeSH terms: Animals, Haplorhini, Brain Mapping, Castration, Feedback, Female, Follicle Stimulating Hormone, Hypothalamus, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Macaca mulatta, Median Eminence, Prolactin, Time Factors

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The Arcuate Nucleus and the Control of Gonadotropin and Prolactin Secretion in the Female Rhesus Monkey (Macaca mulatta)*

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