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The Arcuate Nucleus and the Control of Gonadotropin and Prolactin Secretion in the Female Rhesus Monkey (Macaca mulatta)*
Abstract
Attempts were made to destroy selectively the arcuate nucleus with radiofrequency current in adult female rhesus monkeys as a first step in identifying the areas of the mediobasal hypothalamus (MBH) that are responsible for the neural control of gonadotropin secretion in this species. Extensive or complete destruction of the arcuate region was produced in three animals and in two of these the lesion was confined primarily to the arcuate region and the dorsal aspect of the posterior median eminence. These lesions resulted in the cessation of LH and FSH secretion and blocked the positive feedback action of estradiol on gonadotropin release but did not appear to influence grossly basal thyroid and adrenocortical function, or to abolish GH discharge in response to insulin hypoglycemia. Adenohypophysial infarcts were not observed and exogenous LHRH and TRH induced marked discharges of the appropriate anterior pituitary hormones. In two additional animals with large hypothalamic lesions, destruction of the arcuate region was incomplete. In this group only partial inhibition of gonadotropin secretion was observed. LH and FSH secretion did not appear to be influenced in one animal bearing a large MBH lesion that entirely spared the arcuate region. Although serum prolactin remained at pre-lesion control levels after placement of the two relatively discrete lesions confined to the arcuate region, unambiguous increases in the secretion of this hormone were observed when the area of destruction encompassed tissue anterior and/or dorsal to the arcuate region. These observations suggest that the arcuate region is the primary structure mediating the hypothalamic control of gonadotropin secretion in the rhesus monkey. They also suggest that, in this species, the regions of the MBH involved with the regulation of gonadotropin release and those which control prolactin secretion are anatomically distinct.
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“Although the mechanism that causes the pulsatility of the GnRH neuronal network can be intrinsic to the GnRH neurons themselves,37 lesions of the arcuate nucleus have been shown to abolish LH pulsatility, consistent with the idea that there is a higher order input into the network of GnRH neurons regulating GnRH secretion.38”
From Pubertal development and regulation (2016) · cites this paper as [38]
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Metadata
- Authors
- PLANT, T. M., KREY, L. C., MOOSSY, J., McCORMACK, J. T., HESS, D. L., & KNOBIL, E.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1978-01
- Volume
- 102
- Issue
- 1
- Pages
- 52-62
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2114815180
- Cited by
- 183
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 9 · 2015: 6 · 2014: 6 · 2013: 8 · 2012: 5
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- arcuate nucleus, gonadotropin secretion, prolactin secretion, mediobasal hypothalamus, luteinizing hormone, follicle-stimulating hormone, estradiol positive feedback, hypothalamic-pituitary-gonadal axis, radiofrequency lesions, rhesus monkeys, anterior pituitary, growth hormone
- MeSH terms
- Animals, Haplorhini, Brain Mapping, Castration, Feedback, Female, Follicle Stimulating Hormone, Hypothalamus, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Macaca mulatta, Median Eminence, Prolactin, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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