THE POSSIBLE INVOLVEMENT OF INTESTINAL BACTERIA IN STEROIDAL HYPERTENSION
Abstract
The bacterial flora of rats ws modified, using antibiotics, in order to interrupt the enterohepatic circulation of steroids excreted in bile. Antibiotic treatment was contined while corticosterone was administered to these animals, and over five days corticosterone raised blood pressures by an average of 9.2 mmHg compared with 24.6 mmHg in rats given steroid alone. These findings are consistent with the possibility that in normal rats bacterial metabolites of steroids, when reabsorbed in the enterohepatic circulation, contribute to the physiological response to exogenous steroids.
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Absence of microbiota alters cardiovascular homeostasis, including blood pressure regulation, myocardial repair following post-infarction cardiac repair, and thrombosis growth.
“This is indirectly supported by the fact that absence of microbiota alters cardiovascular homeostasis, such as blood pressure regulation150, myocardial repair following post-infarction cardiac repair66, or thrombosis growth127 – functions that all involve ADRs.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [150]
Cites
Hill, M. J. (2006) · Cancer · doi:10.1002/1097-0142(197512)36:6 · Cited by 195 · see citing works
Comparative study on development of corticosterone and DOCA hypertension in rats
Haack, D., Möhring, J., Möhring, B., Petri, M., & Hackenthal, E. (1977) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1977.233.5.f403 · Cited by 108 · see citing works
Eriksson, H., & Gustafsson, J.-Α. (1970) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1970.tb00987.x · Cited by 67 · see citing works
Kelly, W. G., Bandi, L., Shoolery, J. Ν., & Lieberman, S. (1962) · Biochemistry · doi:10.1021/bi00907a026 · Cited by 61 · see citing works
Urinary steroid excretion in 17α-hydroxylase deficiency
Honour, J. W., TOURNIAIRE, J., Biglieri, E. G., & Shackleton, C. H. L. (1978) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(78)90115-2 · Cited by 48 · see citing works
Self-citationMetabolism of Radiolabeled Corticosterone in an Adult with the 17α-Hydroxylase Deficiency Syndrome*
Shackleton, C. H. L., Biglieri, E. G., Roitman, E., & Honour, J. W. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-48-6-976 · Cited by 33 · see citing works
Self-citationMETABOLITES OF 11-DEHYDROCORTICOSTERONE: PREGNANE-3(α), 20-DIOL-11-ONE
Mason, H. L. (1948) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52767-3 · Cited by 31 · see citing works
BREWSTER, D. W., Jones, R. S., & Symons, A. M. (1977) · Biochemical Pharmacology · doi:10.1016/0006-2952(77)90471-3 · Cited by 24 · see citing works
New mineralocorticoids and adrenocorticosteroids in hypertension
Melby, J. C., & Dale, S. L. (1976) · The American Journal of Cardiology · doi:10.1016/0002-9149(76)90359-3 · Cited by 20 · see citing works
The Enterohepatic Circulation of Aldosterone Metabolites and its Sex-Dependence in Rats
Morris, D. J., HANTOOT, M. S., & DECONTI, G. A. (1977) · Endocrinology · doi:10.1210/endo-101-6-1776 · Cited by 14 · see citing works
Metabolic effects in man of orally and parenterally administered corticosterone (compound B).
Conn, J. W., Fajans, S. S., & Lh, L. (1951) · PubMed · Cited by 14 · see citing works
Buchan, P. C., & Klopper, A. I. (1979) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1979.tb11272.x · Cited by 7 · see citing works
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Gut microbiota in cardiovascular health and disease
Tang, W. H. W., Kitai, T., & Hazen, S. L. (2017) · Circulation Research · doi:10.1161/circresaha.117.309715 · Cited by 1,670 · see citing works
Gut microbiota and cardiovascular disease.
Witkowski, M., Weeks, T. L., & Hazen, S. L. (2020) · Circulation Research · doi:10.1161/circresaha.120.316242 · Cited by 1,051 · see citing works
Alterations in the gut microbiota can elicit hypertension in rats
Adnan, S., Nelson, J. W., Ajami, N. J., Venna, V. R., Petrosino, J. F., Bryan, R. M., & Durgan, D. J. (2016) · Physiological Genomics · doi:10.1152/physiolgenomics.00081.2016 · Cited by 380 · see citing works
The Gut Microbiota (Microbiome) in Cardiovascular Disease and Its Therapeutic Regulation
Rahman, M. M., Islam, F., Harun-Or-Rashid, M., Mamun, A. A., Rahaman, M. S., Islam, M. M., Meem, A. F. K., Sutradhar, P. R., Mitra, S., Mimi, A. A., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.903570 · Cited by 267 · see citing works
Duttaroy, A. K. (2021) · Nutrients · doi:10.3390/nu13010144 · Cited by 232 · see citing works
The Role of Gut Microbiota in Atherosclerosis and Hypertension
Ma, J., & Li, H. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01082 · Cited by 226 · see citing works
The gut microbiota as a novel regulator of cardiovascular function and disease
Battson, M. L., Lee, D. M., Weir, T. L., & Gentile, C. L. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.12.010 · Cited by 185 · see citing works
Santisteban, M. M., Kim, S., Pepine, C. J., & Raizada, M. K. (2016) · Circulation Research · doi:10.1161/circresaha.116.307709 · Cited by 126 · see citing works
The Microbiome and Blood Pressure: Can Microbes Regulate Our Blood Pressure?
Khodor, S. A., Reichert, B., & Shatat, I. F. (2017) · Frontiers in Pediatrics · doi:10.3389/fped.2017.00138 · Cited by 120 · see citing works
Padmanabhan, S., & Joe, B. (2017) · Physiological Reviews · doi:10.1152/physrev.00035.2016 · Cited by 111 · see citing works
Diet-gut microbiota interactions on cardiovascular disease
Zhang, X., & Gérard, P. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.03.028 · Cited by 94 · see citing works
Liu, J., Li, T., Wu, H., Shi, H., Bai, J., Zhao, W., Jiang, D., & Jiang, X. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.01.041 · Cited by 87 · see citing works
Glucocorticoids and gut bacteria: “The GALF Hypothesis” in the metagenomic era
Morris, D. J., & Ridlon, J. M. (2017) · Steroids · doi:10.1016/j.steroids.2017.06.002 · Cited by 63 · see citing works
Microbiome and hypertension: where are we now?
Vallianou, N. G., Geladari, E. V., & Kounatidis, D. C. (2019) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000900 · Cited by 53 · see citing works
Ahmed, S., & Spence, J. D. (2021) · Biology of Sex Differences · doi:10.1186/s13293-021-00378-z · Cited by 50 · see citing works
Morris, D. J., Latif, S., Hardy, M. P., & Brem, A. S. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.03.020 · Cited by 52 · see citing works
Latif, S. A., Pardo, H. A., Hardy, M. P., & Morris, D. J. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.08.006 · Cited by 52 · see citing works
Classic and Nonclassic Apparent Mineralocorticoid Excess Syndrome
Carvajal, C. A., Tapia-Castillo, A., Vecchiola, A., Baudrand, R. F., & Fardella, C. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz315 · Cited by 51 · see citing works
Role of the microbiota in hypertension and antihypertensive drug metabolism
Mishima, E., & Abe, T. (2021) · Hypertension Research · doi:10.1038/s41440-021-00804-0 · Cited by 48 · see citing works
Gut feelings about bacterial steroid-17,20-desmolase
Ly, L. K., Doden, H. L., & Ridlon, J. M. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111174 · Cited by 43 · see citing works
Odermatt, A., & Nashev, L. G. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.01.007 · Cited by 42 · see citing works
Historical perspective: gut dysbiosis and hypertension
Honour, J. W. (2015) · Physiological Genomics · doi:10.1152/physiolgenomics.00063.2015 · Cited by 35 · see citing works
Self-citationConceptualizing the Vertebrate Sterolbiome
Ridlon, J. M. (2020) · Applied and Environmental Microbiology · doi:10.1128/aem.00641-20 · Cited by 34 · see citing works
Gut microbiota and hypertension
Oyama, J., & Node, K. (2019) · Hypertension Research · doi:10.1038/s41440-018-0203-5 · Cited by 33 · see citing works
Morris, D. J., & Brem, A. S. (2019) · Physiological Genomics · doi:10.1152/physiolgenomics.00115.2018 · Cited by 31 · see citing works
Untapped potential of gut microbiome for hypertension management
Gao, K., Wang, P., Mei, X., Yang, T., & Yu, K. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2356278 · Cited by 33 · see citing works
The Gut Microbiome and Cardiovascular Disease
Astudillo, A., & MAYROVITZ, H. N. (2021) · Cureus · doi:10.7759/cureus.14519 · Cited by 32 · see citing works
Gut macrobiotic and its metabolic pathways modulate cardiovascular disease
Zhu, J., Lyu, J., Zhao, R., Liu, G., & Wang, S. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1272479 · Cited by 30 · see citing works
Gut Microbiota and Its Role in the Brain-Gut-Kidney Axis in Hypertension
Vallianou, N. G., Kounatidis, D. C., Panagopoulos, F., Evangelopoulos, A. A., Stamatopoulos, V., Papagiorgos, A., Geladari, E. V., & Dalamaga, Μ. (2023) · Current Hypertension Reports · doi:10.1007/s11906-023-01263-3 · Cited by 29 · see citing works
Magalhães, N. S., Savino, W., Silva, P., Martins, M. A., & Carvalho, V. F. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.644751 · Cited by 29 · see citing works
Yang, Y., Karampoor, S., Mirzaei, R., Бороздкин, Л. Л., & Zhu, P. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110546 · Cited by 24 · see citing works
An alternative explanation of hypertension associated with 17α-hydroxylase deficiency syndrome
Morris, D. J., Latif, S. A., & Brem, A. S. (2013) · Steroids · doi:10.1016/j.steroids.2013.10.006 · Cited by 24 · see citing works
Ahmed, L. A., & Al‐Massri, K. F. (2022) · Current Molecular Pharmacology · doi:10.2174/1874467215666220222105004 · Cited by 23 · see citing works
Qin, Y., Zhao, J., Wang, Y., Bai, M., & Sun, S. (2022) · Kidney & Blood Pressure Research · doi:10.1159/000524282 · Cited by 23 · see citing works
Wang, X., Li, Y., Li, H., Gu, Y., Song, Y., Zhang, Q., Liu, L., Meng, G., Yao, Z., Wu, H., et al. (2018) · Journal of Human Hypertension · doi:10.1038/s41371-018-0029-2 · Cited by 22 · see citing works
Prospects for Leveraging the Microbiota as Medicine for Hypertension
Durgan, D. J., Zubcevic, J. A., Vijay–Kumar, M., Yang, T., Manandhar, I., Aryal, S., Muralitharan, R. R., Li, H., Li, Y., Abais‐Battad, J. M., et al. (2024) · Hypertension · doi:10.1161/hypertensionaha.124.21721 · Cited by 20 · see citing works
Why do humans have two glucocorticoids: A question of intestinal fortitude
Morris, D. J. (2015) · Steroids · doi:10.1016/j.steroids.2015.06.017 · Cited by 19 · see citing works
Gut Microbiota and Cardiovascular System: An Intricate Balance of Health and the Diseased State
Bhat, M. A., Mishra, A. K., Tantray, J. A., Alatawi, H. A., Saeed, M., Rahman, S., & Jan, A. T. (2022) · Life · doi:10.3390/life12121986 · Cited by 19 · see citing works
Sex-Specific Differences in the Pathophysiology of Hypertension
Zhang, H., Singal, P. K., Ravandi, A., & Rabinovich-Nikitin, I. (2025) · Biomolecules · doi:10.3390/biom15010143 · Cited by 17 · see citing works
Mehta, V., Nagu, P., Inbaraj, B. S., Sharma, M., Parashar, A., & Sridhar, K. (2022) · Bioengineering · doi:10.3390/bioengineering9120798 · Cited by 17 · see citing works
Yi, D., Li, T., Xiao, Y., Zhang, X., Hao, Q., Zhang, F., Qiu, T., Yang, G., Sun, X., Dong, Y., et al. (2024) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10728 · Cited by 13 · see citing works
Kothmann, K., Jons, A., Wilhelmi, B., Kasozi, N., Graham, L., Gent, R., Atkin, S. L., Swart, A. C., & Newell‐Fugate, A. E. (2022) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2022.114099 · Cited by 13 · see citing works
Microbiota in a long survival discourse with the human host
Ayariga, J. A., Ibrahim, I., Gildea, L., Abugri, J., & Villafañe, R. (2022) · Archives of Microbiology · doi:10.1007/s00203-022-03342-6 · Cited by 12 · see citing works
Microbial Metabolites and Cardiovascular Dysfunction: A New Era of Diagnostics and Therapy
Kumar, J. (2025) · Cells · doi:10.3390/cells14161237 · Cited by 13 · see citing works
Morris, D. J., Brem, A. S., & Odermatt, A. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105988 · Cited by 13 · see citing works
Viglioli, M., Rizzo, S. M., Alessandri, G., Fontana, F., Milani, C., Turroni, F., Mancabelli, L., Croci, N., Rivara, S., Vacondio, F., et al. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124663 · Cited by 11 · see citing works
Mirzahosseini, H. K., Esmaeili, M., & Mirakhorli, A. (2025) · Journal of Microbiota · doi:10.5812/jmb-159140 · Cited by 11 · see citing works
Ikeda, T., Tanaka, Y., Yamamoto, K., Morii, H., Kamisako, T., & Ogawa, H. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.08.018 · Cited by 11 · see citing works
Genetically determined hypertensive phenotype affects gut microbiota composition, but not vice versa
Konopelski, P., Konop, M., Perlejewski, K., Bukowska‐Ośko, I., Radkowski, M., Onyszkiewicz, M., Jaworska, K., Mogilnicka, I., Samborowska, E., & Ufnal, M. (2021) · Journal of Hypertension · doi:10.1097/hjh.0000000000002864 · Cited by 11 · see citing works
Microglia, the Missing Link in the Brain-Gut-Hypertension Axis
Touyz, R. M., & Camargo, L. L. (2019) · Circulation Research · doi:10.1161/circresaha.119.314718 · Cited by 11 · see citing works
Protective effects of kefir in the angiotensin II-dependent hypertension
Monteiro, B. L., Dias, A. T., Wanderkoke, S. D. C., Yokota, R., Casarini, D. E., Leal, M. A. S., Nogueira, B. V., Meyrelles, S. S., Campos‐Toimil, M., Campagnaro, B. P., et al. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104260 · Cited by 10 · see citing works
Vascular and inflammatory mineralocorticoid receptors in kidney disease
Barrera‐Chimal, J., & Jaisser, F. (2019) · Acta Physiologica · doi:10.1111/apha.13390 · Cited by 9 · see citing works
Microbiota and Metabolites as Factors Influencing Blood Pressure Regulation
Yang, T., Chakraborty, S., Mandal, J., Mei, X., & Joe, B. (2021) · Comprehensive physiology · doi:10.1002/cphy.c200009 · Cited by 8 · see citing works
Gut Microbiota: A New Regulator of Cardiovascular Function
Bulgakova, S. V., Захарова, Н. О., & Иванович, Р. П. (2021) · Bulletin of Science and Practice · doi:10.33619/2414-2948/62/20 · Cited by 5 · see citing works
Morris, D. J., Latif, S. A., Lo, Y. H., Abrampah, K., Brem, A. S., Litchfield, W. R., & Williams, G. H. (2008) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2008.01.001 · Cited by 4 · see citing works
Research Progress on the Influence of Gut Microbiota on Metabolic Syndrome-Associated Stroke
杨, 常. (2021) · Advances in Clinical Medicine · doi:10.12677/acm.2021.118507 · Cited by 4 · see citing works
A historical perspective on the role of micro-organisms in steroid pharmacology and endocrinology
Honour, J. W. (2025) · Microbiota and Host · doi:10.1530/mah-25-0005 · Cited by 3 · see citing works
Self-citationAldosterone 21-sulphate in man
Jowett, T. P., & Slater, J. D. H. (1983) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(83)90068-7 · Cited by 3 · see citing works
FAILURE OF NEOMYCIN TO MODIFY ACTH INDUCED HYPERTENSION IN SHEEP
Tresham, J. J., Coghlan, J. P., Denton, D. A., Scoggins, B. A., & Whitworth, J. A. (1984) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1984.tb00877.x · Cited by 3 · see citing works
Odermatt, A., & Morris, D. J. (2026) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2026.106954 · Cited by 2 · see citing works
Microbiota intestinal e síndrome metabólica: utilização terapêutica de probióticos
da Silva, L. P., Rovai, R. B., Rezende, J. J. D., Mercês, B. G. D., Silva, C. B. F. T. D., & Masquio, D. C. L. (2023) · Revista da Associação Brasileira de Nutrição - RASBRAN · doi:10.47320/rasbran.2022.1451 · Cited by 4 · see citing works
The Novel Dimensions of Cardio-Metabolic Health: Gut Microbiota, Dysbiosis and its Fallouts
Vinod, N. (2019) · Significances of Bioengineering & Biosciences · doi:10.31031/sbb.2019.03.000565 · Cited by 2 · see citing works
The Novel Dimensions of Cardio-Metabolic Health: Gut Microbiota, Dysbiosis and its Fallouts
Nikhra, V. (2019) · Current Research in Diabetes & Obesity Journal · doi:10.19080/crdoj.2019.11.555805 · Cited by 2 · see citing works
Gut microbial function and bacterially derived signals in cardiovascular disease
Kitai, T., & Tang, W. H. W. (2017) · The Biochemist · doi:10.1042/bio03902022 · Cited by 2 · see citing works
Honour, J. W. (2026) · RSC Advances · doi:10.1039/d5ra08275g · Cited by 1 · see citing works
Self-citationRosario-Castro, S., Rojas-García, D., & Sánchez, I. P. (2023) · Medicina y Laboratorio · doi:10.36384/01232576.623 · Cited by 1 · see citing works
Breakdown and clearance of steroids
Honour, J. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-818124-9.00001-2 · Cited by 1 · see citing works
Self-citationApparent Mineralocorticoid Excess
Carvajal, C. A., Tapia-Castillo, A., Uslar, T., & Fardella, C. (2023) · Endocrinology · doi:10.1007/978-3-031-27119-9_11 · Cited by 1 · see citing works
Gorospe, W. C., & Conn, P. M. (1987) · Current topics in membranes and transport · doi:10.1016/s0070-2161(08)60058-1 · Cited by 1 · see citing works
Intestinal Microflora and Clinical Medicine
KANAZAWA, K. (2003) · Bioscience and Microflora · doi:10.12938/bifidus1996.22.39
Gastroenterocardiology: Or what do the gut and the heart have in common?
Joksimović, Z., Bastać, D., & Pavlović, S. (2021) · Timocki medicinski glasnik · doi:10.5937/tmg2101011j
Gut microbiota and their effects on atherosclerosis, platelet function, and hypertension
Duttaroy, A. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822405-2.00022-0
Preventive and Therapeutic Role of Probiotics in Type-2 Diabetes and Its Associated Complications
Subramani, S. K., Raghuwanshi, S., & Sharma, R. (2022) · Springer eBooks · doi:10.1007/978-981-16-8444-9_7
Apparent Mineralocorticoid Excess
Carvajal, C. A., Tapia-Castillo, A., Uslar, T., & Fardella, C. (2022) · Endocrinology · doi:10.1007/978-3-030-44628-4_11-1
Honour, J. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-818124-9.00012-7
Self-citationClassic and “non-classic” apparent mineralocorticoid excess
Baudrand, R. F., Carvajal, C. A., Tapia-Castillo, A., Uslar, T., & Fardella, C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00223-5
Microbiota and Metabolites as Factors Influencing Blood Pressure Regulation
Yang, T., Chakraborty, S., Mandal, J., Mei, X., & Joe, B. (2021) · Comprehensive physiology · doi:10.1002/j.2040-4603.2021.tb00158.x
Dietary Index for Gut Microbiota is negatively associated with HypertensionPreprint
Fu, Y., Peng, M., Cai, H., Zhang, Y., Zheng, Y., & Li, B. (2025) · Research Square · doi:10.21203/rs.3.rs-6437987/v1
Gut microbiota as a pharmacological target in cardiovascular diseases
Eslami, M., Banihashemian, S. Z., Alibabaei, F., Mohammadlou, M., & Babaeizad, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27370-4.00027-5 · Cited by 1 · see citing works
The Microbiota as a Potential Cause of Disease
Santangelo, G., Lamorgese, L., Tonti, N., Porpora, M. G., Palaia, I., Tomao, F., Donato, V. D., Fischetti, M., Mascio, D. D., Giancotti, A., et al. (2026) · Diseases · doi:10.3390/diseases14070260
- Authors
- HONOUR, J.
- Corresponding author
- HONOUR, JOHN
- ORCID
- HONOUR, JOHN
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1982-01
- Volume
- 110
- Issue
- 1
- Pages
- 285-287
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W1996666406
- Cited by
- 80
- References
- 12
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 4 · 2023: 8 · 2022: 10 · 2021: 14 · 2020: 3 · 2019: 9 · 2018: 2 · 2017: 6 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Keywords
- intestinal bacteria, gut microbiota, corticosterone, enterohepatic circulation, antibiotic-induced dysbiosis, blood pressure, rats
- MeSH terms
- Animals, Bacteria, Bile, Blood Pressure, Body Weight, Corticosterone, Hypertension, Intestines, Male, Neomycin, Rats, Inbred Strains, Steroids, Rats
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