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Atypical Synergistic α1- and β-Adrenergic Regulation of Adenosine 3′,5′-Monophosphate and Guanosine 3′,5′- Monophosphate in Rat Pinealocytes
Abstract
The adrenergic control of cAMP and 3',5'-cyclic GMP (cGMP) in dispersed adult rat pinealocytes was investigated. Norepinephrine treatment increased cAMP and cGMP content 60- and 400-fold, respectively; both alpha- and beta-adrenoceptors had to be activated for these responses to occur. Beta-Adrenergic stimulation alone produced only about 6- and 2-fold increase in cAMP and cGMP content, respectively. Alpha-Adrenergic stimulation, which alone had no effect on either cyclic nucleotide concentration, markedly amplified the beta-adrenergic stimulation of both cAMP and cGMP. The relative potency of alpha-adrenergic agonists and antagonists indicates the alpha 1-subclass of adrenoceptors is involved. A role of alpha 1-adrenoceptors in the control of pineal cAMP is consistent with published evidence of the presence of alpha 1-adrenoceptors on pinealocytes and their role in the regulation of N-acetyltransferase activity and melatonin production.
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Cited by
Simonneaux, V., & Ribelayga, C. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.2 · Cited by 740
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Reiter, R. J. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90087-9 · Cited by 632
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Kay, R. W. (1994) · British Journal of Psychiatry · doi:10.1192/bjp.164.3.403 · Cited by 108
Metadata
- Authors
- VANECEK, J., SUGDEN, D., WELLER, J., & KLEIN, D. C.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1985-06
- Volume
- 116
- Issue
- 6
- Pages
- 2167-2173
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2077061468
- Cited by
- 253
- References
- 0
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Atypical Synergistic α1- and β-Adrenergic Regulation of Adenosine 3′,5′-Monophosphate and Guanosine 3′,5′- Monophosphate in Rat Pinealocytes. https://app.cochat.ai/papers/10.1210/endo-116-6-2167
- The paper
- VANECEK, J., SUGDEN, D., WELLER, J., & KLEIN, D. C. (1985). Atypical Synergistic α1- and β-Adrenergic Regulation of Adenosine 3′,5′-Monophosphate and Guanosine 3′,5′- Monophosphate in Rat Pinealocytes. Endocrinology. https://doi.org/10.1210/endo-116-6-2167
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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