The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Circadian variations in plasma corticosterone permit normal termination of adrenocorticotropin responses to stress
Abstract
We previously reported that adrenalectomized rats given constant corticosterone via a sc pellet (B-PELLET) hypersecrete ACTH in response to stress. Although lacking a feedback signal, B-PELLET rats do not secrete ACTH indefinitely after stress; plasma ACTH levels in these animals returned to those in sham-operated (SHAM) rats within 1-4 h after 2-min restraint. To distinguish between the requirement for circadian or stress-induced increases in corticosterone, we compared changes in ACTH and corticosterone levels after stress in SHAM and B-PELLET rats with those in cyanoketone-treated rats (CK) and adrenalectomized rats given corticosterone in their drinking fluid (B-WATER). B-WATER rats exhibited sustained increases in plasma corticosterone after lights-off, correlating with the nocturnal feeding period. Morning plasma corticosterone levels in B-WATER rats were constant and even lower than those in B-PELLET rats; however, B-WATER rats did not differ from SHAM rats in their ACTH response to ip injection. CK rats, which have an approximately normal circadian corticosterone rhythm but do not have significant corticosterone responses to acute stimuli, also exhibited plasma ACTH levels similar to those of SHAM rats at all times after 5-min restraint. Compared with SHAM and B-WATER rats in the same experiment, B-PELLET rats tended to hypersecrete ACTH 60 min after 5 min of restraint, but only had significantly elevated plasma ACTH relative to both groups 45 min after 10 min of restraint. We conclude that circadian, rather than stress-induced, increases in corticosterone may be sufficient for normal termination of ACTH responses to stress.
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“Indeed, if circadian patterns of CORT are disrupted by adrenalectomy (ADX) and tonic replacement of CORT via a pellet implant providing no diurnal rhythm, this results in a “sluggish” HPA axis response, with poor shutoff of adrenocorticotropic hormone following termination of a stressor, in contrast to the situation in which the ADX animal drinks CORT in the water in a diurnal pattern.18”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [18]
In the citing paper
“The differential regulation of cellular rhythms in different brain regions is of particular interest when considering “healthy” regulation of HPA function requires rhythmic glucocorticoids, as discussed above.18”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [18]
Citations
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McEwen, B. S., & Akil, H. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.0733-19.2019 · Cited by 686
“This termination is based on a negative feedback mechanism that is mediated at many levels—the pituitary, the PVN, and, especially, the hippocampus, which is rich in GR but in which the diurnal variation of glucocorticoids primes the system to turn off the HPA response rather than acting like a thermostat (Akana et al…”
BackgroundEnhancing versus suppressive effects of stress hormones on skin immune function
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Metadata
- Authors
- JACOBSON, L., AKANA, S. F., CASCIO, C. S., SHINSAKO, J., & DALLMAN, M. F.
- Affiliations
- University of California, San Francisco (US)
- ORCID
- JACOBSON, LAUREN
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1988-04
- Volume
- 122
- Issue
- 4
- Pages
- 1343-1348
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W1989636587
- Cited by
- 143
- References
- 19
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 4 · 2019: 7 · 2018: 8 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (KD28172)
- National Heart, Lung, and Blood Institute (HL29714)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- circadian rhythm, corticosterone, ACTH, ACTH secretion, stress response, adrenalectomy, cyanoketone, restraint stress, hypothalamic-pituitary-adrenal axis, nocturnal feeding
- MeSH terms
- Adrenalectomy, Adrenocorticotropic Hormone, Animals, Circadian Rhythm, Corticosterone, Male, Rats, Inbred Strains, Stress, Physiological, Time Factors, Rats
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