The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Estrogen Treatment Prevents Osteopenia and Depresses Bone Turnover in Ovariectomized Rats*
Abstract
Female Sprague-Dawley rats were subjected to bilateral ovariectomy (OVX) or sham surgery (control). Groups of ovariectomized (OVX) and control rats were injected daily with low, medium, or high doses of 17 beta-estradiol (10, 25, or 50 micrograms/kg BW, respectively). An additional group of OVX and control rats was injected daily with vehicle alone. All rats were killed 35 days after OVX, and their proximal tibiae were processed undecalcified for quantitative bone histomorphometry. Trabecular bone volume was markedly reduced in vehicle-treated OVX rats relative to that in control rats (12.1% vs. 26.7%). This bone loss was associated with a 2-fold increase in osteoclast surface and a 4-fold increase in osteoblast surface. The bone formation rate, studied with fluorochrome labeling, was also significantly elevated in vehicle-treated OVX rats (0.111 vs. 0.026 micron3/micron2.day). In contrast, treatment of OVX rats with the three doses of estradiol resulted in normalization of tibial trabecular bone volume and a decline in histomorphometric indices of bone resorption and formation. Our results indicate that estrogen treatment provides complete protection against osteopenia in OVX rats. The protective mechanism involves estrogenic suppression of bone turnover. These findings are consistent with the skeletal effects of estrogen therapy in postmenopausal women.
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Citations
Cites
Prevention of early postmenopausal bone loss: controlled 2‐year study in 315 normal females
CHRISTIANSEN, C., CHRISTENSEN, M. S., McNAIR, P., HAGEN, C., STOCKLUND, K., & TRANSBØL, I. (1980) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1980.tb00033.x · Cited by 603
Effect of Estrogens and Calcium Carbonate on Bone Loss in Postmenopausal Women
RECKER, R. R., SAVILLE, P. D., & HEANEY, R. P. (1977) · Annals of Internal Medicine · doi:10.7326/0003-4819-87-6-649 · Cited by 563
Biologic effects of transdermal estradiol
Chetkowski, R., Meldrum, D., & Steingold, K. (1987) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(87)90325-0 · Cited by 467
Skeletal alterations in ovariectomized rats
Wronski, T. J., Lowry, P. L., Walsh, C. C., & Ignaszewski, L. A. (1985) · Calcified Tissue International · doi:10.1007/bf02554882 · Cited by 376
Self-citationThe effects of ovariectomy and 17β-estradiol on cortical bone histomorphometry in growing rats
Turner, R. T., Vandersteenhoven, J. J., & Bell, N. H. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020206 · Cited by 347
Histologic evidence for osteopenia and increased bone turnover in ovariectomized rats
Wronski, T. J., Walsh, C. C., & Ignaszewski, L. A. (1986) · Bone · doi:10.1016/8756-3282(86)90683-6 · Cited by 316
Self-citationEffect of body weight on osteopenia in ovariectomized rats
Wronski, T. J., Schenk, P. A., Cintrón, M., & Walsh, C. C. (1987) · Calcified Tissue International · doi:10.1007/bf02555700 · Cited by 258
Self-citationCHRISTIANSEN, C., CHRISTENSEN, M. S., LARSEN, N.-E., & TRANSBØL, I. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-6-1124 · Cited by 209
Bone remodeling and its relationship to metabolic bone diseases
Frost, H. M. (1973) · Medical Entomology and Zoology · Cited by 162
Cited by
The ovariectomized rat model of postmenopausal bone loss
Kalu, D. N. (1991) · Bone and Mineral · doi:10.1016/0169-6009(91)90124-i · Cited by 1,361
Vanderschueren, D., Vandenput, L., Boonen, S., Lindberg, M. K., Bouillon, R., & Ohlsson, C. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0003 · Cited by 717
The Phytoestrogen Genistein Reduces Bone Loss in Short-Term Ovariectomized Rats
Fanti, P., Monier-Faugere, M. C., Geng, Z., Schmidt, J., Morris, P. E., Cohen, D., & Malluche, H. H. (1998) · Osteoporosis International · doi:10.1007/s001980050065 · Cited by 283
Kimble, R. B., Matayoshi, A. B., Vannice, J. L., Kung, V. T., Williams, C., & Pacifici, R. (1995) · Endocrinology · doi:10.1210/endo.136.7.7789332 · Cited by 273
Chow, J., Tobias, J. H., Colston, K. W., & Chambers, T. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115588 · Cited by 269
Metadata
- Authors
- WRONSKI, T. J., CINTRON, M., DOHERTY, A. L., & DANN, L. M.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1988-08
- Volume
- 123
- Issue
- 2
- Pages
- 681-686
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2019308648
- Cited by
- 356
- References
- 9
- FWCI
- 14.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Estrogen Treatment Prevents Osteopenia and Depresses Bone Turnover in Ovariectomized Rats*. https://app.cochat.ai/papers/10.1210/endo-123-2-681
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- WRONSKI, T. J., CINTRON, M., DOHERTY, A. L., & DANN, L. M. (1988). Estrogen Treatment Prevents Osteopenia and Depresses Bone Turnover in Ovariectomized Rats*. Endocrinology. https://doi.org/10.1210/endo-123-2-681
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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