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MACROPHAGE COLONY STIMULATING FACTOR RESTORES IN VIVO BONE RESORPTION IN THE OP/OP OSTEOPETROTIC MOUSE
Abstract
The op/op variant of murine osteopetrosis is a recessive mutation characterized by impaired bone resorption due to lack of osteoclasts. Cultured osteoblasts and fibroblasts from this mutant do not secrete M-CSF activity and resident macrophages are absent in bone marrow. This failure has been related to a mutation within the M-CSF coding region. We report now that the administration of recombinant human M-CSF (rhM-CSF) corrects in vivo the impaired bone resorption in this animal. The treatment restores the bone marrow cavity virtually absent in the op/op animal and induces the appearance of resorbing osteoclasts and of resident bone marrow macrophages. This proves that the deficiency of M-CSF is the cause of the op/op bone disorder and that this cytokine is directly or indirectly necessary for physiological osteoclastogenesis, the resulting bone resorption and for the establishment of bone marrow hemopoiesis.
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Citations
Cited by
Bone Resorption by Osteoclasts
Teitelbaum, S. L. (2000) · Science · doi:10.1126/science.289.5484.1504 · Cited by 3,962
Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis
Pacifici, R. (1996) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650110802 · Cited by 741
Engsig, M. T., Chen, Q.-J., Vu, T. H., Pedersen, A.-C., Therkidsen, B., Lund, L. R., Henriksen, K., Lenhard, T., Foged, N. T., Werb, Z., et al. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.4.879 · Cited by 596
Pollard, J. W., Hunt, J. S., Wiktor-Jedrzejczak, W., & Stanley, E. R. (1991) · Developmental Biology · doi:10.1016/0012-1606(91)90336-2 · Cited by 337
Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.
Lowe, C., Yoneda, T., Boyce, B. F., Chen, H., Mundy, G. R., & Soriano, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4485 · Cited by 329
Metadata
- Authors
- Felix, R., Cecchini, M. G., & Fleisch, H.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1990-11
- Volume
- 127
- Issue
- 5
- Pages
- 2592-2594
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2073614902
- Cited by
- 438
- References
- 0
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: MACROPHAGE COLONY STIMULATING FACTOR RESTORES IN VIVO BONE RESORPTION IN THE OP/OP OSTEOPETROTIC MOUSE. https://app.cochat.ai/papers/10.1210/endo-127-5-2592
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- Felix, R., Cecchini, M. G., & Fleisch, H. (1990). MACROPHAGE COLONY STIMULATING FACTOR RESTORES IN VIVO BONE RESORPTION IN THE OP/OP OSTEOPETROTIC MOUSE. Endocrinology. https://doi.org/10.1210/endo-127-5-2592
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
