Bone Resorption by Osteoclasts

Teitelbaum, Steven L.

doi:10.1126/science.289.5484.1504

Cited by 3,962Bone Metabolism and DiseasesBone health and osteoporosis researchBone and Dental Protein Studies

Bone Resorption by Osteoclasts

Teitelbaum, Steven L.·2000·Science

DOI 10.1126/science.289.5484.1504

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Abstract

Osteoporosis, a disease endemic in Western society, typically reflects an imbalance in skeletal turnover so that bone resorption exceeds bone formation. Bone resorption is the unique function of the osteoclast, and anti-osteoporosis therapy to date has targeted this cell. The osteoclast is a specialized macrophage polykaryon whose differentiation is principally regulated by macrophage colony-stimulating factor, RANK ligand, and osteoprotegerin. Reflecting integrin-mediated signals, the osteoclast develops a specialized cytoskeleton that permits it to establish an isolated microenvironment between itself and bone, wherein matrix degradation occurs by a process involving proton transport. Osteopetrotic mutants have provided a wealth of information about the genes that regulate the differentiation of osteoclasts and their capacity to resorb bone.

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Osteoclast formation from macrophages is principally regulated by M-CSF, RANKL, and OPG.
“Formation of osteoclasts from macrophages is principally regulated by macrophage colony-stimulating factor, RANK ligand (RANKL), and osteoprotegerin (OPG) [259].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [259]

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Authors: Teitelbaum, S. L.
Affiliations: Barnes-Jewish Hospital (US)
Corresponding author: Teitelbaum, Steven L.
ORCID: Teitelbaum, Steven L.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2000-09
Volume: 289
Issue: 5484
Pages: 1504-1508
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.289.5484.1504
OpenAlex: W1967502057
Cited by: 3,962
References: 5
Citations by year: 2026: 82 · 2025: 123 · 2024: 142 · 2023: 151 · 2022: 159 · 2021: 188 · 2020: 202 · 2019: 199 · 2018: 200 · 2017: 163 · 2016: 155 · 2015: 184 · 2014: 176 · 2013: 161 · 2012: 196
FWCI: 7.69
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
Keywords: bone resorption, osteoclasts, osteoporosis, osteoclastogenesis, macrophage colony-stimulating factor, RANK ligand, osteoprotegerin, integrins, cytoskeleton, matrix degradation, proton transport, bone turnover
MeSH terms: Animals, Bone Resorption, Carrier Proteins, Cell Differentiation, Cell Membrane, Glycoproteins, Humans, Macrophages, Membrane Glycoproteins, Osteoclasts, Osteopetrosis, Integrins, Macrophage Colony-Stimulating Factor, Stromal Cells, Receptors, Tumor Necrosis Factor, Receptors, Cytoplasmic and Nuclear, Osteoprotegerin, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B

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