The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index.
Chronic streptozotocin diabetes in rats facilitates the acute stress response without altering pituitary or adrenal responsiveness to secretagogues.
Abstract
We have used streptozotocin (STZ)-induced diabetes in rats to determine whether this represents a sustained stimulus to the adrenocortical system and whether STZ-diabetic rats are able to mount an acute stress response. Furthermore, we compared pituitary responsiveness to CRF and/or arginine vasopressin, and adrenal responsiveness to ACTH in STZ- vs. vehicle-treated rats. We also compared the efficacy of dexamethasone inhibitory feedback in STZ-diabetic and control rats. Our results show that STZ-treated rats chronically hypersecrete corticosterone (B) as evidenced by their decreased thymus weights, their increased urinary B excretion, and their elevated mean plasma B levels during the light hours of the day. Despite the evidence for sustained hypersecretion of B, STZ-treated rats showed greater and more prolonged ACTH and B responses to the acute stress of histamine injection. However, when tested separately, neither pituitary nor adrenal responsiveness to their secretagogues were increased in STZ-diabetic compared to control rats. Dexamethasone inhibition of stress-induced B secretion was tested using two different paradigms: pentobarbital-anesthetized rats were given iv injections of acid saline, and awake rats were given ip injections of histamine. In both experiments the STZ-treated rats were relatively resistant to glucocorticoid inhibition of stress responses. This finding, taken together with the exaggerated ACTH and B responses to stress, strongly suggests that the facilitatory effects of chronic STZ-diabetes are a consequence of changes in sensitivity of central neural components of the adrenocortical system to stimulatory and/or inhibitory inputs, in conjunction with changes in glucocorticoid feedback sensitivity.
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“Elevated plasma glucagon and corticosterone levels are implicated in the pathogenesis of hyperglycemia in uDM (29 -31).”
From Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia (2011) · cites this paper as [31]
Citations
Cites
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Corticosteroid inhibition of acth secretion
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Gold, P. W., Loriaux, D. L., Roy, A., Kling, M. A., Calabrese, J. R., Kellner, C. H., Nieman, L. K., Post, R. M., Pickar, D., Gallucci, W. T., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605223142101 · Cited by 766
Regulation of ACTH Secretion: Variations on a Theme of B
DALLMAN, M. F., AKANA, S. F., CASCIO, C. S., DARLINGTON, D. N., JACOBSON, L., & LEVIN, N. (1987) · Proceedings of the 1986 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571143-2.50010-1 · Cited by 655
Abnormal Hypothalamic–Pituitary–Adrenal Function in Anorexia Nervosa
Gold, P. W., Gwirtsman, H. E., Avgerinos, P. C., Nieman, L. K., Gallucci, W. T., Kaye, W. H., Jimerson, D. C., Ebert, M. H., Rittmaster, R. S., Loriaux, D. L., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605223142102 · Cited by 457
Intracellular Receptor Concentration Limits Glucocorticoid-Dependent Enhancer Activity*
Vanderbilt, J. N., Miesfeld, R. L., Maler, B. A., & Yamamoto, K. R. (1987) · Molecular Endocrinology · doi:10.1210/mend-1-1-68 · Cited by 349
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Habituation to repeated stress is stressor specific
Jean Kant, G., Eggleston, T., Landman-Roberts, L., Kenion, C. C., Driver, G. C., & Meyerhoff, J. L. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90286-2 · Cited by 225
Corticosterone: narrow range required for normal body and thymus weight and ACTH
Akana, S. F., Cascio, C. S., Shinsako, J., & Dallman, M. F. (1985) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1985.249.5.r527 · Cited by 199
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Björntorp, P. A., & Rosmond, R. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00422-6 · Cited by 584
Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system
Whitnall, M. H. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90035-q · Cited by 582
Bhatnagar, S., & Dallman, M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00577-0 · Cited by 511
Stress, Feedback and Facilitation in the Hypothalamo‐Pituitary‐Adrenal Axis
Dallman, M., Akana, S., Scribner, K. A., Bradbury, M. J., Walker, C., Strack, A. M., & Cascio, C. S. (1992) · Journal of neuroendocrinology · doi:10.1111/j.1365-2826.1992.tb00200.x · Cited by 418
Sullivan, R. M., & Gratton, A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02834.1999 · Cited by 377
Metadata
- Authors
- SCRIBNER, K. A., WALKER, C.-D., CASCIO, C. S., & DALLMAN, M. F.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1991-07
- Volume
- 129
- Issue
- 1
- Pages
- 99-108
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2124250661
- Cited by
- 112
- References
- 44
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2020: 1 · 2018: 2 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, San Francisco
- National Institute of Diabetes and Digestive and Kidney Diseases (DK28172)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- streptozotocin-induced diabetes, chronic diabetes, acute stress response, corticosterone, ACTH secretion, pituitary responsiveness, vasopressin, corticotropin-releasing factor, glucocorticoid negative feedback, thymus weight, adrenal response
- MeSH terms
- Adrenal Glands, Adrenocorticotropic Hormone, Animals, Arginine Vasopressin, Circadian Rhythm, Corticosterone, Corticotropin-Releasing Hormone, Dexamethasone, Diabetes Mellitus, Experimental, Histamine, Male, Pituitary Gland, Rats, Inbred Strains, Stress, Physiological, Rats
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