Cited by 225Stress Responses and CortisolMemory and Neural MechanismsNeuropeptides and Animal Physiology

Habituation to repeated stress is stressor specific

Jean Kant, G., Eggleston, Terence, Landman-Roberts, Leigh, Kenion, Clyde C., Driver, Golden C., Meyerhoff, James L.·1985·Pharmacology Biochemistry and Behavior

Abstract

Rats were exposed to 15 min of restraint or footshock or forced running in an activity wheel once a day for 10 days. Control groups were handled only. On the 11th day, rats from each stressor group and controls were exposed to 15 min of one stressor in a crossed design such that all combinations of one chronic stressor and one acute stressor were performed. Rats were sacrificed immediately following removal from their home cage or after 15 min stressor exposure on the 11th day and plasma corticosterone and prolactin and pituitary cyclic AMP levels were determined. There were no measured differences in these stress indices among groups of rats sacrificed immediately upon removal from their home cage on day 11 regardless of previous history on days 1 through 10. Plasma corticosterone and plasma prolactin and pituitary cyclic AMP levels were elevated in all rats exposed to any of the three stressors immediately prior to sacrifice as compared to all rats not exposed to stress immediately before sacrifice. However, plasma prolactin and pituitary cyclic AMP responses to each of the 3 stressors were attenuated in rats which had previous exposure to that specific stressor as compared to rats which had previous experience with a different or no stressor. We conclude that habituation results from behavioral experience with a particular stressor rather than biochemical adaptation resulting from repeated challenge to hormonal and neurochemical systems responsive to stress.

Integrity signals

Registry

Crossref · 10.1016/0091-3057(85)90286-2

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The HPA-axis and the inflammatory arm of the immune system respond and habituate differently to various types of stressors.

    “Notably, the HPA-axis and inflammatory arm of the immune system respond and habituate differently to various types of stressors (Bowers et al., 2008; Kant et al., 1985; Kuhlman et al., 2014; Pacák, 1999; Pacák et al., 1998, 1995; Sheridan and McLaughlin, 2014; Weiner,”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Jean Kant, G., Eggleston, T., Landman-Roberts, L., Kenion, C. C., Driver, G. C., & Meyerhoff, J. L.
Affiliations
Walter Reed National Military Medical Center (US)
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
1985-04
Volume
22
Issue
4
Pages
631-634
ISSN
0091-3057 (ISSN-L)
OpenAlex
W2084736187
Cited by
225
References
16
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 8 · 2014: 5 · 2013: 9 · 2012: 5
FWCI
3.91
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
stressor specificity, chronic stress, restraint stress, footshock, forced running, corticosterone, prolactin, stress adaptation, behavioral experience, rats
MeSH terms
Cyclic AMP, Animals, Corticosterone, Electroshock, Physical Exertion, Habituation, Psychophysiologic, Humans, Male, Pituitary Gland, Prolactin, Rats, Inbred Strains, Restraint, Physical, Stress, Psychological, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review